Iron oxide nanoparticle-induced hematopoietic and immunological response in rats

Gaharwar, Usha Singh; Kumar, Sumit; Rajamani, Paulraj

doi:10.1039/d0ra05901c

Cited by 17 publications

(12 citation statements)

References 45 publications

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“…It is also used as a food additive in iron-fortified drinks and cereals for human consumption [ 2 ] besides numerous industrial uses in wastewater treatment, gas sensing and semiconductors sorbents lubrications, pigments and coatings [ 3 ]. However, the diverse usage of IONPs induces iron overload and the subsequent initiation of oxidative stress in various organs [ 4 ]. Ingestion, inhalation and dermal penetration are the main routes for the entry of IONPs [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats

Dora

Taha

Lebda

et al. 2021

IJMS

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Iron oxide nanoparticle (IONP) therapy has diverse health benefits but high doses or prolonged therapy might induce oxidative cellular injuries especially in the brain. Therefore, we conducted the current study to investigate the protective role of quercetin supplementation against the oxidative alterations induced in the brains of rats due to IONPs. Forty adult male albino rats were allocated into equal five groups; the control received a normal basal diet, the IONP group was intraperitoneally injected with IONPs of 50 mg/kg body weight (B.W.) and quercetin-treated groups had IONPs + Q25, IONPs + Q50 and IONPs + Q100 that were orally supplanted with quercetin by doses of 25, 50 and 100 mg quercetin/kg B.W. daily, respectively, administrated with the same dose of IONPs for 30 days. IONPs induced significant increases in malondialdehyde (MDA) and significantly decreased reduced glutathione (GSH) and oxidized glutathione (GSSG). Consequently, IONPs significantly induced severe brain tissue injuries due to the iron deposition leading to oxidative alterations with significant increases in brain creatine phosphokinase (CPK) and acetylcholinesterase (AChE). Furthermore, IONPs induced significant reductions in brain epinephrine, serotonin and melatonin with the downregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and mitochondrial transcription factor A (mtTFA) mRNA expressions. IONPs induced apoptosis in the brain monitored by increases in caspase 3 and decreases in B-cell lymphoma 2 (Bcl2) expression levels. Quercetin supplementation notably defeated brain oxidative damages and in a dose-dependent manner. Therefore, quercetin supplementation during IONPs is highly recommended to gain the benefits of IONPs with fewer health hazards.

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Section: Introductionmentioning

confidence: 99%

Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats

Dora

Taha

Lebda

et al. 2021

IJMS

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“…Even FDA approved some of the IONPs, ferumoxytol and ferumoxides, for use in MRI. Since IONPs are superparamagnetic, they can be used for medical imaging or magnetic drug targeting (MDT) [55,56]. Various studies have been reporting the discrepant results on IONP toxicological effects, some claiming that there is no significant toxicity while others reported severe consequences.…”

Section: Toxicological Effects Of Various Nanoparticlesmentioning

confidence: 99%

“…Various studies have been reporting the discrepant results on IONP toxicological effects, some claiming that there is no significant toxicity while others reported severe consequences. A recent study dealt with in vivo toxicity induced by ultrafine IONPs in rats [56]. The results of 4 weeks of exposure to IONPs showed to be decreasing in bone marrow-mononuclear cell proliferation, with high ROS levels, increased inflammatory response, and DNA changes leading to an apoptotic outcome.…”

Section: Toxicological Effects Of Various Nanoparticlesmentioning

confidence: 99%

“…The results of 4 weeks of exposure to IONPs showed to be decreasing in bone marrow-mononuclear cell proliferation, with high ROS levels, increased inflammatory response, and DNA changes leading to an apoptotic outcome. Although structural spleen tissue damage had not been noticed, the level of oxidative stress markers in tissue was extremely high, suggesting that high doses of IONPs may cause significant toxicity in the organism [56,57]. One can be exposed to IONPs also via inhalation, and by entering the respiratory tract, these nanoparticles may become extremely deleterious, thereby causing pulmonary inflammation, tissue fibrosis, changes in pulmonary function, and immunological response.…”

Section: Toxicological Effects Of Various Nanoparticlesmentioning

confidence: 99%

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An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle‐Induced Toxicities

Mihailović

Stanković

Selaković

et al. 2021

Oxidative Medicine and Cellular Longevity

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Nanoparticles (NPs) are used in many products and materials for humans such as electronics, in medicine for drug delivery, as biosensors, in biotechnology, and in agriculture, as ingredients in cosmetics and food supplements. Besides that, NPs may display potentially hazardous properties on human health and the environment as a consequence of their abundant use in life nowadays. Hence, there is increased interest of researchers to provide possible therapeutic agents or dietary supplements for the amelioration of NP-induced toxicity. This review summarizes the new findings in the research of the use of antioxidants as supplements for the prevention and alleviation of harmful effects caused by exposure of organisms to NPs. Also, mechanisms involved in the formation of NP-induced oxidative stress and protective mechanisms using different antioxidant substances have also been elaborated. This review also highlights the potential of naturally occurring antioxidants for the enhancement of the antioxidant defense systems in the prevention and mitigation of organism damage caused by NP-induced oxidative stress. Based on the presented results of the most recent studies, it may be concluded that the role of antioxidants in the prevention and treatment of nanoparticle-induced toxicity is unimpeachable. This is particularly important in terms of oxidative stress suppression.

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“…8,10–13 Additionally, uptake of particles may alter cytokine secretion, chemotaxis behavior, oxidative burst, and nitric oxide generation in these cells. 13–20 However, it remains unclear if the uptake of particles would affect the ability of a phagocytic immune cell to subsequently phagocytose and neutralize a pathogen.…”

Section: Introductionmentioning

confidence: 99%

Particle Uptake Driven Phagocytosis in Macrophages and Neutrophils Enhances Bacterial Clearance

Sharma

Vijaykumar

Raghavan

et al. 2021

Preprint

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Humans are exposed to numerous synthetic foreign particulates in the form of environmental pollutants and diagnostic or therapeutic agents. Specialized immune cells (phagocytes) clear these particulates by phagocytosing and attempting to degrade them. The process of recognition and internalization of the particulates may trigger changes in the function of phagocytes. Some of these changes, especially the ability of a particle-loaded phagocyte to take up and neutralize pathogens, remains poorly studied. Herein, we demonstrate that the uptake of non-stimulatory cargo-free particles enhances the phagocytic ability of monocytes, macrophages and neutrophils. The enhancement in phagocytic ability was independent of particle properties, such as size or the base material constituting the particle. Additionally, we show that the increased phagocytosis was not a result of cellular activation or cellular heterogeneity but was driven by changes in cell membrane fluidity and cellular compliance. A consequence of the enhanced phagocytic activity was that particulate-laden immune cells neutralize E. coli faster in culture. Moreover, when administered in mice as a prophylactic, particulates enable faster clearance of E. coli and S. epidermidis. Together, we demonstrate that the process of uptake induces cellular changes that favor additional phagocytic events. This study provides insights into using non-stimulatory cargo-free particles to engineer immune cell functions for applications involving faster clearance of phagocytosable particulates.

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Iron oxide nanoparticle-induced hematopoietic and immunological response in rats

Abstract: The application and use of iron oxide nanoparticless (IONPs) in the biomedical field are steadily increasing, although it remains uncertain whether IONPs are safe or should be used with caution.

Cited by 17 publications

References 45 publications

Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats

Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats

An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle‐Induced Toxicities

Particle Uptake Driven Phagocytosis in Macrophages and Neutrophils Enhances Bacterial Clearance

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