Iron oxide nanoparticles augment the intercellular mitochondrial transfer–mediated therapy

Huang, Ting; Zhang, Tianyuan; Jiang, Xinyi; Ai, Li; Su, Yuanqin; Bian, Qiong; Wu, Honghui; Lin, Ruyi; Li, Ni; Cao, Hong; Ling, Daishun; Wang, Jinqiang; Tabata, Yasuhiko; Gu, Zhen

doi:10.1126/sciadv.abj0534

Cited by 67 publications

(47 citation statements)

References 49 publications

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“…The content of ATP was measured with a commercial kit (BC0300, Solarbio Life Sciences, Beijing, China) following the instruction provided elsewhere (Huang et al ., 2021). The activity of ATPase was measured with a commercial kit (A016‐1‐1, Nanjing Jiancheng Bioengineering Institute, Nanjing, China) following the instruction provided elsewhere (Li et al ., 2017).…”

Section: Methodsmentioning

confidence: 99%

Antifungal effect of o‐vanillin on mitochondria of Aspergillus flavus: ultrastructure and TCA cycle are destroyed

Zhao

Zhu

et al. 2022

Int J of Food Sci Tech

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Aspergillus flavus (A. flavus) is a conditioned pathogen that severely endangers food safety. This study is aimed to determine the mode of action of o‐vanillin against A. flavus mitochondria. First, o‐vanillin hindered respiration. Furthermore, the mitochondrial ultrastructures were damaged with scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterisation. The activities of the tricarboxylic acid (TCA) cycle‐related enzymes were regulated significantly (P < 0.05), and the most significant reduction and promotion was citrate synthase (CS) and malic dehydrogenase (MDH), respectively, at 100 μg mL−1 of o‐vanillin. Consistent with the above phenotypic results, real‐time quantitative reverse transcription polymerase chain reaction (PCR) (QRT‐PCR) results showed that the relative expressions of genes encoding the TCA‐related enzymes were regulated remarkably (P < 0.05), especially for CIT1 gene (downregulated) and MDH gene (upregulated). This study demonstrated the damage of o‐vanillin on mitochondria and shed light on the antifungal mechanism of o‐vanillin against A. flavus.

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Section: Methodsmentioning

confidence: 99%

Antifungal effect of o‐vanillin on mitochondria of Aspergillus flavus: ultrastructure and TCA cycle are destroyed

Zhao

Zhu

et al. 2022

Int J of Food Sci Tech

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“…Ionized IONPs promote the formation of C×43-containing GJCs (C×43-GJCs), which selectively promote the transfer of hMSC mitochondria to damaged cells. In a mouse model of pulmonary fibrosis, IONP-engineered hMSCs promoted intercellular mitochondrial transfer and significantly alleviated fibrosis progression without any safety concerns [ 159 ].…”

Section: Strategies For Mitochondrial-transfer Optimizationmentioning

confidence: 99%

Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease

et al. 2022

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Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD), are rising in both incidence and prevalence and remain a major global health and socioeconomic burden in the twenty-first century. Despite an increasing understanding of these diseases, the lack of effective treatments remains an ongoing challenge. Mitochondria are key players in intracellular energy production, calcium homeostasis, signaling, and apoptosis. Emerging evidence shows that mitochondrial dysfunction participates in the pathogeneses of metabolic diseases. Exogenous supplementation with healthy mitochondria is emerging as a promising therapeutic approach to treating these diseases. This article reviews recent advances in the use of mitochondrial transplantation therapy (MRT) in such treatment.

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“…These properties make MSCs suitable for ARDS treatment [32]. MSCs have been used to treat lung injury in the preclinical settings [33][34][35][36][37]. Of the 42 registered clinical trials on ARDS treatment, seven have been completed, according to the US National Institutes of Health (https:// clini caltr ials.…”

Section: Msc-based Therapymentioning

confidence: 99%

Extracellular Vesicles Derived from Mesenchymal Stem Cells: A Potential Biodrug for Acute Respiratory Distress Syndrome Treatment

Sun

Zhang

2022

BioDrugs

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Acute respiratory distress syndrome (ARDS) is a severe respiratory disease associated with high morbidity and mortality in the clinic. In the face of limited treatment options for ARDS, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have recently shown promise. They regulate levels of growth factors, cytokines, and other internal therapeutic molecules. The possible therapeutic mechanisms of MSC-EVs include anti-inflammatory, cell injury repair, alveolar fluid clearance, and microbe clearance. The potent therapeutic ability and biocompatibility of MSC-EVs have enabled them as an alternative option to ameliorate ARDS. In this review, recent advances, therapeutic mechanisms, advantages and limitations, as well as improvements of using MSC-EVs to treat ARDS are summarized. This review is expected to provide a brief view of the potential applications of MSC-EVs as novel biodrugs to treat ARDS.

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Iron oxide nanoparticles augment the intercellular mitochondrial transfer–mediated therapy

Cited by 67 publications

References 49 publications

Antifungal effect of o‐vanillin on mitochondria of Aspergillus flavus: ultrastructure and TCA cycle are destroyed

Antifungal effect of o‐vanillin on mitochondria of Aspergillus flavus: ultrastructure and TCA cycle are destroyed

Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease

Extracellular Vesicles Derived from Mesenchymal Stem Cells: A Potential Biodrug for Acute Respiratory Distress Syndrome Treatment

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