Iron oxide nanoparticles for immune cell labeling and cancer immunotherapy

Chung, Seok-Hwan; Revia, Richard A.; Zhang, Miqin

doi:10.1039/d1nh00179e

Cited by 33 publications

(25 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The IONPs demonstrate biodegradability, they are distributed in different organs of the body, and no long-term toxicity has been reported. 37 A recent experiment revealed the role of folic acid (FA)-modified IONPs in diagnosis of breast cancer. 38 Notably, IONPs can be used for curcumin delivery in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, all of these physicochemical parameters should be optimized before addressing the critical issues in the nanomedicine field, in which these optimizations showed critical feedbacks in the diagnosis and treatment perspectives of SARS-CoV-2 as well. − Iron oxide nanoparticles (IONPs) are extensively utilized for diagnostic aims and MRI contrast due to their superparamagnetic tools, and they show various beneficial characteristics including high solubility and biocompatibility. The IONPs demonstrate biodegradability, they are distributed in different organs of the body, and no long-term toxicity has been reported . A recent experiment revealed the role of folic acid (FA)-modified IONPs in diagnosis of breast cancer .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Farani

Azarian

Hossein

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Cancer is a deadly disease that has long plagued humans and has become more prevalent in recent years. The common treatment modalities for this disease have always faced many problems and complications, and this has led to the discovery of strategies for cancer diagnosis and treatment. The use of magnetic nanoparticles in the past two decades has had a significant impact on this. One of the objectives of the present study is to introduce the special properties of these nanoparticles and how they are structured to load and transport drugs to tumors. In this study, iron oxide (Fe 3 O 4 ) nanoparticles with 6 nm sizes were coated with hyperbranched polyglycerol (HPG) and folic acid (FA). The functionalized nanoparticles (10–20 nm) were less likely to aggregate compared to non-functionalized nanoparticles. HPG@Fe 3 O 4 and FA@HPG@Fe 3 O 4 nanoparticles were compared in drug loading procedures with curcumin. HPG@Fe 3 O 4 and FA@HPG@Fe 3 O 4 nanoparticles’ maximal drug-loading capacities were determined to be 82 and 88%, respectively. HeLa cells and mouse L929 fibroblasts treated with nanoparticles took up more FA@HPG@Fe 3 O 4 nanoparticles than HPG@Fe 3 O 4 nanoparticles. The FA@HPG@Fe 3 O 4 nanoparticles produced in the current investigation have potential as anticancer drug delivery systems. For the purpose of diagnosis, incubation of HeLa cells with nanoparticles decreased MRI signal enhancement’s percentage and the largest alteration was observed after incubation with FA@HPG@Fe 3 O 4 nanoparticles.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Farani

Azarian

Hossein

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…Nanoparticles are often used to specifically deliver antigens, adjuvants, and therapeutic agents 298,299 . Nanoparticles themselves can also regulate immune microenvironment of tumors [300][301][302][303] .…”

Section: Immunotherapymentioning

confidence: 99%

“…Many inorganic nanoparticles, such as gold nanoparticles 304,305 and iron oxide nanoparticles 302 , have been used in immunotherapy. With the development of ruthenium antitumor drugs, some ruthenium molecules and nanoparticles are considered new candidates for immunotherapy.…”

Section: Immunotherapymentioning

confidence: 99%

Ruthenium-based antitumor drugs and delivery systems from monotherapy to combination therapy

Zhu

et al. 2022

Nanoscale

View full text Add to dashboard Cite

show abstract

“…Lactobacillus fermentum reduces Fe (III) to Fe (II) and increases its absorption [ 140 ]. A very interesting discovery regarding the use of iron oxide nanoparticles (IONP) in cancer immunotherapy was described by Chung et al [ 141 ]. IONPs can be used to stimulate immune cells to increase their activity at the tumor site and improve the response to cancer immunotherapy.…”

Section: Micronutrients Gut Microbiome and Cancermentioning

confidence: 99%

Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients

Frąk

Grenda²,

Krawczyk³

et al. 2022

Cancers

View full text Add to dashboard Cite

The effectiveness of immunotherapy in cancer patients depends on the activity of the host’s immune system. The intestinal microbiome is a proven immune system modulator, which plays an important role in the development of many cancers and may affect the effectiveness of anti-cancer therapy. The richness of certain bacteria in the gut microbiome (e.g., Bifidobacterium spp., Akkermanisa muciniphila and Enterococcus hire) improves anti-tumor specific immunity and the response to anti-PD-1 or anti-PD-L1 immunotherapy by activating antigen-presenting cells and cytotoxic T cells within the tumor. Moreover, micronutrients affect directly the activities of the immune system or regulate their function by influencing the composition of the microbiome. Therefore, micronutrients can significantly influence the effectiveness of immunotherapy and the development of immunorelated adverse events. In this review, we describe the relationship between the supply of microelements and the abundance of various bacteria in the intestinal microbiome and the effectiveness of immunotherapy in cancer patients. We also point to the function of the immune system in the case of shifts in the composition of the microbiome and disturbances in the supply of microelements. This may in the future become a therapeutic target supporting the effects of immunotherapy in cancer patients.

show abstract

Iron oxide nanoparticles for immune cell labeling and cancer immunotherapy

Abstract: Cancer immunotherapy is a novel approach to cancer treatment that leverages components of the immune system as opposed to chemotherapeutics or radiation. Cell migration is an integral process in a...

Cited by 33 publications

References 165 publications

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Ruthenium-based antitumor drugs and delivery systems from monotherapy to combination therapy

Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients

Contact Info

Product

Resources

About