Iron oxide-supported copper oxide nanoparticles catalyzed synthesis of propargyl amine derivatives via multicomponent approach

Shirole, Gopinath D.; Kadnor, Vijay A.; Gaikwad, Sanjay S.; Kshirsagar, Nilesh; Mhaske, Ganesh; Shelke, Sharad N.

doi:10.1007/s11164-015-2319-4

Res Chem Intermed

2015

DOI: 10.1007/s11164-015-2319-4

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Iron oxide-supported copper oxide nanoparticles catalyzed synthesis of propargyl amine derivatives via multicomponent approach

Gopinath D. Shirole¹,

Vijay A. Kadnor²,

Sanjay S. Gaikwad³

et al.

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Cited by 12 publications

References 48 publications

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One‐Step Synthesis of Novel Erlotinib Analogs Catalyzed by Nano‐CuO as Potent Anticancer Agent

Moghadam,

Mokhtary,

Evazalipour

2024

Applied Organom Chemis

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Twenty new substituted erlotinib analogs with anticancer activity were produced with good to excellent yields through the one‐step reaction of erlotinib, aromatic aldehydes, and cyclic secondary amines such as piperidine, morpholine, pyrrolidine, N‐methylpiperazine, or imidazole using nano‐CuO in choline chloride: urea (ChCl:urea) solvent under ultrasound irradiation at 80°C. MTT protocol was applied to investigate the cytotoxicity of all produced substituted erlotinib analogs in A431 (human epidermoid carcinoma cell) and HU02 (foreskin fibroblast) cell lines. The results illustrated that at a concentration of less than 10 μM, the growth of A431 cells could be inhibited by the produced compounds. Compared to erlotinib as positive control, the highest cytotoxic activity with IC50 equal to 2.58 ± 0.57 μM belonged to compound 4c carrying 4‐fluorobenzene with piperidine substitution. All of the synthesized compounds showed significant cytotoxic activity on A431, while showing no apparent cytotoxicity to HU02. The reasons for the stronger cytotoxic activity 4c can be most probably attributed to the two phenomena of greater solubility of the fluoro derivative and the flexibility of piperidine. Based on this study, compound 4c is the most promising compound with anticancer properties.

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One‐Step Synthesis of Novel Erlotinib Analogs Catalyzed by Nano‐CuO as Potent Anticancer Agent

Moghadam,

Mokhtary,

Evazalipour

2024

Applied Organom Chemis

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Nano and Sub-nano Gold–Cobalt Particles as Effective Catalysts in the Synthesis of Propargylamines via AHA Coupling

et al. 2020

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Brønsted-acidic ionic liquid: green protocol for synthesis of novel tetrasubstituted imidazole derivatives under microwave irradiation via multicomponent strategy

Shirole¹,

Kadnor²,

Tambe³

et al. 2016

Res Chem Intermed

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Iron oxide-supported copper oxide nanoparticles catalyzed synthesis of propargyl amine derivatives via multicomponent approach

Cited by 12 publications

References 48 publications

One‐Step Synthesis of Novel Erlotinib Analogs Catalyzed by Nano‐CuO as Potent Anticancer Agent

One‐Step Synthesis of Novel Erlotinib Analogs Catalyzed by Nano‐CuO as Potent Anticancer Agent

Nano and Sub-nano Gold–Cobalt Particles as Effective Catalysts in the Synthesis of Propargylamines via AHA Coupling

Brønsted-acidic ionic liquid: green protocol for synthesis of novel tetrasubstituted imidazole derivatives under microwave irradiation via multicomponent strategy

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