2024
DOI: 10.1002/ajh.27267
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Iron restriction in sickle cell disease: When less is more

Oswaldo L. Castro,
Lucia De Franceschi,
Tomas Ganz
et al.

Abstract: Primum non nocere! Can iron deficiency, an abnormality that causes anemia, benefit people with sickle cell disease (SCD) who already have an anemia? The published literature we review appears to answer this question in the affirmative: basic science considerations, animal model experiments, and noncontrolled clinical observations all suggest a therapeutic potential of iron restriction in SCD. This is because SCD's clinical manifestations are ultimately attributable to the polymerization of hemoglobin S (HbS), … Show more

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