Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial

Cogswell, Mary E.; Parvanta, Ibrahim; Ickes, Liza; Yip, Ray; Brittenham, Gary M.

doi:10.1093/ajcn/78.4.773

Cited by 331 publications

(325 citation statements)

References 17 publications

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“…Work by Gambling et al [77] highlighted that the timing of iron supplementation is critical in reversing the effects of maternal anemia on the developing fetus and postnatal sequelae in offspring. These data correlate well with human studies showing that iron supplementation during pregnancy leads to a higher mean birth weight and reduced incidence of low birth weight infants [78] . Maternal chromium restriction significantly increased body weight and fat percentage, especially central adiposity, in both male and female rat offspring [79,80] .…”

Section: Maternal Undernutritionsupporting

confidence: 89%

Developmental programming of the metabolic syndrome - critical windows for intervention

Vickers

2011

WJG

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Metabolic disease results from a complex interaction of many factors, including genetic, physiological, behavioral and environmental influences. The recent rate at which these diseases have increased suggests that environmental and behavioral influences, rather than genetic causes, are fuelling the present epidemic. In this context, the developmental origins of health and disease hypothesis has highlighted the link between the periconceptual, fetal and early infant phases of life and the subsequent development of adult obesity and the metabolic syndrome. Although the mechanisms are yet to be fully elucidated, this programming was generally considered an irreversible change in developmental trajectory. Recent work in animal models suggests that developmental programming of metabolic disorders is potentially reversible by nutritional or targeted therapeutic interventions during the period of developmental plasticity. This review will discuss critical windows of developmental plasticity and possible avenues to ameliorate the development of postnatal metabolic disorders following an adverse early life environment.

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Section: Maternal Undernutritionsupporting

confidence: 89%

Developmental programming of the metabolic syndrome - critical windows for intervention

Vickers

2011

WJG

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“…Treatment significantly revert the levels of above aforementioned parameters. Present results are similar to previous reports [25][26]. Serum TfR is the most sensitive indicator of iron status when there is tissue iron deficiency and the serum ferritin concentration is the most sensitive indicator of iron status when there are residual iron stores.…”

Section: Discussionsupporting

confidence: 92%

Effect of Iron Supplementation on Plasma Lipid Levels in Pregnant Anemic Women

2016

IJSR

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“…The adverse consequences of maternal anaemia include fatigue, decreased work capacity and poor pregnancy outcomes such as preterm birth, low birth weight, and increased risk of maternal death both during delivery and the postpartum period (2,3) . Even though yBenin, Burkina Faso, Cameroon, Cape Verde, Central African Republic, Chad, Congo, Democratic Republic of the Congo,…”

Section: Women Anaemia Urgent Action West and Central Africamentioning

confidence: 99%

Maternal anaemia in West and Central Africa: time for urgent action

Ayoya

Bendech

Zagré

et al. 2011

Public Health Nutr.

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Objective: To review the prevalence, severity and determinants of anaemia among women in West and Central Africa (WCA) and raise awareness among policy makers and programme planners in the region. Design: Systematic descriptive review of data in the public domain of the ORC Macro MEASURE Demographic and Health Surveys, national nutrition surveys, oral and technical communications at regional meetings, studies published in scientific journals, and WHO and UNICEF databases. Setting: West and Central Africa region. Subjects: Women of childbearing age. Results: The prevalence of anaemia among pregnant and non-pregnant women is higher than 50 % and 40 %, respectively, in all countries. Within countries, this prevalence varies by living setting (rural v. urban), women's age and education. Across countries, socio-economic and climatic differences have no apparent association with the prevalence of anaemia among women. Several factors contribute either alone or jointly to the high rates of maternal anaemia in this region. These include widespread nutritional deficiencies; high incidence of infectious diseases; low access to and poor quality of health services; low literacy rates; ineffective design, implementation and evaluation of anaemia control programmes; and poverty. Conclusions: Addressing the multiple causes and minimizing the consequences of anaemia on maternal and child health and development in WCA require integrated multifactorial and multisectoral strategies. This also calls for unprecedented, historical and stronger political will and commitment that put adolescent girls and maternal health at the centre of the development agenda. Keywords Women Anaemia Urgent action West and Central AfricaMaternal anaemia continues to be a major barrier to women's health, social development and economic growth, especially in the developing world. The WHO estimates that, globally, anaemia affects 42 % (56?4 million) of pregnant women and 30 % (468?4 million) of non-pregnant women (including adolescent girls). In Africa, 57 % (17?2 million) of pregnant women and 48 % (70 million) of nonpregnant women (including adolescent girls) are anaemic (1) . In Sub-Saharan Africa, and more particularly in the West and Central Africa Region (WCAR),y high rates of anaemia continue unabated in women throughout their reproductive years. In WCAR, according to WHO classification, the prevalence of anaemia among women of reproductive age is of severe public health significance; i.e. at any point in time at least 40 % of women (15-49 years old) are anaemic (1) .These high rates represent significant constraints for achieving some of the Millennium Development Goals such as eradicating hunger and poverty (Goal 1), reducing child mortality (Goal 4) and improving maternal health (Goal 5). The adverse consequences of maternal anaemia include fatigue, decreased work capacity and poor pregnancy outcomes such as preterm birth, low birth weight, and increased risk of maternal death both during delivery and the postpartum period (2,3) . Even tho...

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Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial

Abstract: Prenatal prophylactic iron supplementation deserves further examination as a measure to improve birth weight and potentially reduce health care costs.

Cited by 331 publications

References 17 publications

Developmental programming of the metabolic syndrome - critical windows for intervention

Developmental programming of the metabolic syndrome - critical windows for intervention

Effect of Iron Supplementation on Plasma Lipid Levels in Pregnant Anemic Women

Maternal anaemia in West and Central Africa: time for urgent action

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