Irradiating or Autoclaving Chitosan/Polyol Solutions: Effect on Thermogelling Chitosan-.BETA.-glycerophosphate Systems.

Jarry, Claire; Leroux, Jean‐Christophe; Haeck, Jonathan; Chaput, Cyril

doi:10.1248/cpb.50.1335

Cited by 56 publications

(37 citation statements)

References 29 publications

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“…The hydroxyl radicals react with hyaluronan with a rate constant k 2 = 0.9 x 10 9 mol -1 dm 3 s -1 , whereas H atoms rate is a lower order of magnitude k 2 = 7 x 10 7 mol -1 dm 3 s -1 (Myint et al, 1987). Figure 11 shows the various hydrolysis, rearrangement, and fragmentation reactions during aqueous radiolysis of cellobiose to gives possible chain break (Sonntag, 1987 Fei et al, 2000;Liu et al, 2002b;Wach et al, 2003a;) (Fei et al, 2000;Liu et al, 2002b;Wach et al, 2001;Wach et al, 2003a;) Hydroxy ethyl cellulose (Fei et al, 2000;Wach et al, 2003a) (Fei et al, 2000;Wach et al, 2001) chitin, chitosan & derivatives (Ershov et al, 1993;Ershov, 1998;Jarry et al, 2001;Jarry et al, 2002;) (Wasikiewicz et al, 2005) Cellulose & derivatives (Ershov, 1998;Nakamura et al, 1985;Phillips, 1961;Phillips, 1963;Wach et al, 2002) (Phillips & Moody, 1959;Wach et al, 2002) Starch and derivatives (Ershov, 1998;Nagasawa et al, 2004;Phillips, 1961;Zhai et al, 2003) D-glucose (Phillips, 1963;Schiller et al, 1998) (Sharpatyi, 2003) Hyaluronan & hyaluronic acid (Al-Assaf et al, 1995;Al-Assaf et al, 2006a;Ershov, 1998;…”

Section: Aqueous State Radiationmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

259

178

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Section: Aqueous State Radiationmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

259

178

View full text Add to dashboard Cite

“…There have been documented some investigations about the influence of different sterilization procedures on the thermogelling ability of this system. Autoclaving and steam sterilization may significantly affect the molecular weight and viscosity of chitosan, but do not impair its ability to form gels upon heating [12,13]. However, γ-radiation markedly changed its thermogelling properties [13].…”

Section: Applicationsmentioning

confidence: 99%

“…Autoclaving and steam sterilization may significantly affect the molecular weight and viscosity of chitosan, but do not impair its ability to form gels upon heating [12,13]. However, γ-radiation markedly changed its thermogelling properties [13]. Regarding the angiogenic potential of Cs-GP system, results indicate that this system does not contribute to enhance angiogenesis, while the presence of human bone marrow-derived mesenchymal stem cells resulted in an increased angiogenic response after 3 days of placement on the chick chorioallantoic membrane [14].…”

Section: Applicationsmentioning

confidence: 99%

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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“…In order to increase the stability of polymeric material, numerous studies have been reported by the researchers on the binary mixtures of CH with natural (starch), poly (ethylene oxide), polyvinylopyrrolidone (PVP) polymers, synthetic poly (vinyl alcohol) (Jarry et al, 2002;Mucha et al, 2005;Cervera et al, 2004;Khoo et al, 2003;Verma et al, 2016). Combination of HPMC K15 and CH in the matrix system has been reported to provide retardation in the drug release profile by one of the author of presented research work (Soni et al, 2016;Soni et al, 2017a).…”

Section: Introductionmentioning

confidence: 99%

Formulation and investigation of crushed puffed rice-chitosan-HPMC based polymeric blends as carrier for sustained stomach specific drug delivery of piroxicam using 3(2) Taguchi mathematical design studies

2018

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In the present experimental investigation an attempt has been made to assess the utility of Crushed Puffed Rice (CPR)-High Molecular Weight Chitosan (HMWCH)-Hydroxypropyl Methylcellulose K15M (HPMC K15M) as a polymeric carrier for the sustained stomach delivery of Piroxicam (PRX). A total of nine formulations were prepared by using 3 (2) Taguchi factorial design, physically blending drug and polymer(s) followed by encapsulation into hard gelatin capsules size 1. The prepared capsules were evaluated for various performance such as weight variation, drug contents, in vitro buoyancy and drug release in 0.1 M HCl. The effect of drug loading on in vitro performance of the formulations was also determined. Crushed puffed rice (CPR) remained buoyant for up to average time span of 06 hr as an unwetted irregular mass in 0.1 M HCl. However, when combined with HMWCH or HPMC K15M or HPMC K15M + HMWCH a low -density cylindrical raft type hydrogel was formed which remained buoyant for up to 12 hr and released up to 99% drug in a sustained manner from 8 to 12 hr following zero order release kinetics. It was also observed that drug release from drug + CPR matrices followed Fickian mechanism. Combination of CPR + HMWCH or HMWCH + HPMC K15M also follows Fickian mechanism. Obtained data from the research work suggests that CPR in combination with HMWCH or HPMC K15M or HPMC has sufficient potential to be used as a carrier for stomach specific delivery of gastric irritant drug like PRX.Soni et al., International Current Pharmaceutical Journal, April 2018, 6(11): 61-80http://www.icpjonline.com/documents/Vol6Issue11/01.pdf

show abstract

Irradiating or Autoclaving Chitosan/Polyol Solutions: Effect on Thermogelling Chitosan-.BETA.-glycerophosphate Systems.

Cited by 56 publications

References 29 publications

Hydrogels: Methods of Preparation, Characterisation and Applications

Hydrogels: Methods of Preparation, Characterisation and Applications

Chitosan-Based Thermosensitive Materials

Formulation and investigation of crushed puffed rice-chitosan-HPMC based polymeric blends as carrier for sustained stomach specific drug delivery of piroxicam using 3(2) Taguchi mathematical design studies

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