Irradiation effects on polycaprolactone

Narkis, M.; Sibony-Chaouat, S.; Siegmann, A.; Shkol'nik, S.M.; Bell, James P.

doi:10.1016/0032-3861(85)90056-4

Cited by 86 publications

(65 citation statements)

References 10 publications

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“…39,40 The literature reported the effect of γ-irradiation on PεCL structure; upon irradiation, the polymer displays cross-linking between polymeric chains or even between surfactant and PεCL chains. 41 As can be seen in Figure 1D, the release profile of NPs did not significantly change after γ-irradiation. Only the intrinsic viscosity of FB-PεCL-NPs using PEG added increased from 5.425 mPa/s to 6.594 mPa/s after irradiation.…”

Section: In Vitro Drug Releasementioning

confidence: 73%

The influence of freeze drying and &upsih;-irradiation in pre-clinical studies of flurbiprofen polymeric nanoparticles for ocular delivery using D-(+)-trehalose and polyethylene glycol

Yacasi¹,

López²,

Espina³

et al. 2016

IJN

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This study investigated the suspension of poly(ε-caprolactone) nanoparticles as an ocular delivery system for flurbiprofen (FB-PεCL-NPs) in order to overcome the associated problems, such as stability, sterility, tolerance, and efficacy, with two different FB-PεCL-NP formulations. The formulations were stabilized with poloxamer 188 (1.66% and 3.5%) and submitted individually for freeze-drying and γ-irradiation with polyethylene glycol 3350 (PEG3350) and d -(+)-trehalose (TRE). Both formulations satisfied criteria according to all physicochemical parameters required for ocular pharmaceuticals. The FB-PεCL-NP formulations showed non-Newtonian behavior and sustained drug release. Ex vivo permeation analysis using isolated ocular pig tissues suggested that the presence of PEG3350 results in a reduction of FB transcorneal permeation. Moreover, TRE improved the penetration of FB across the cornea, especially after γ-irradiation. In addition, both formulations did not show a significant affinity in increasing FB transscleral permeation. Both formulations were classified as nonirritating, safe products for ophthalmic administration according to hen’s egg test-chorioallantoic membrane and Draize eye test. Furthermore, an in vivo anti-inflammatory efficacy test showed that irradiated FB-PεCL-NPs prepared with PEG3350 (IR-NPsPEG) have longer anti-inflammatory effects than those presented with irradiated FB-PεCL-NPs prepared with TRE (IR-NPsTRE). IR-NPsPEG showed a suitable physical stability after an aqueous reconstitution over >30 days. This study concludes that both formulations meet the Goldman’s criteria and demonstrate how irradiated nanoparticles, with innovative permeation characteristics, could be used as a feasible alternative to a flurbiprofen solution for ocular application in clinical trials.

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Section: In Vitro Drug Releasementioning

confidence: 73%

The influence of freeze drying and &upsih;-irradiation in pre-clinical studies of flurbiprofen polymeric nanoparticles for ocular delivery using D-(+)-trehalose and polyethylene glycol

Yacasi¹,

López²,

Espina³

et al. 2016

IJN

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“…Narkis et al (1985) found that gamma irradiation induced chain scission and cross-linking [7], but their work focussed mainly on much higher doses than that required for sterilisation. Masson et al (1997) used the standard sterilisation dose of 25 kGy but were concerned only with PCL nanospheres [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material

Cottam

Hukins

Lee

et al. 2009

Medical Engineering & Physics

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“…Gamma radiation was preferred as a method of sterilisation due to its high efficiency, high penetration and negligible thermal effects [61]. However, gamma sterilisation is known to induce molecular changes for polymeric materials by chain scission and crosslinking [61][62][63]. Therefore, the effect of gamma sterilisation on LC scaffolds was also evaluated by compression testing prior to and post sterilisation as shown in figure 6.…”

Section: Scaffold Treatmentmentioning

confidence: 99%

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization

et al. 2016

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The manufacture of 3D scaffolds with specific controlled porous architecture, defined microstructure and an adjustable degradation profile was achieved using two-photon polymerization (TPP) with a size of 2 × 4 × 2 mm3. Scaffolds made from poly(D,L-lactide-co-ɛ-caprolactone) copolymer with varying lactic acid (LA) and ɛ -caprolactone (CL) ratios (LC16:4, 18:2 and 9:1) were generated via ring-opening-polymerization and photoactivation. The reactivity was quantified using photo-DSC, yielding a double bond conversion ranging from 70% to 90%. The pore sizes for all LC scaffolds were see 300 μm and throat sizes varied from 152 to 177 μm. In vitro degradation was conducted at different temperatures; 37, 50 and 65 °C. Change in compressive properties immersed at 37 °C over time was also measured. Variations in thermal, degradation and mechanical properties of the LC scaffolds were related to the LA/CL ratio. Scaffold LC16:4 showed significantly lower glass transition temperature (Tg) (4.8 °C) in comparison with the LC 18:2 and 9:1 (see 32 °C). Rates of mass loss for the LC16:4 scaffolds at all temperatures were significantly lower than that for LC18:2 and 9:1. The degradation activation energies for scaffold materials ranged from 82.7 to 94.9 kJ mol−1. A prediction for degradation time was applied through a correlation between long-term degradation studies at 37 °C and short-term studies at elevated temperatures (50 and 65 °C) using the half-life of mass loss (Time (M1/2)) parameter. However, the initial compressive moduli for LC18:2 and 9:1 scaffolds were 7 to 14 times higher than LC16:4 (see 0.27) which was suggested to be due to its higher CL content (20%). All scaffolds showed a gradual loss in their compressive strength and modulus over time as a result of progressive mass loss over time. The manufacturing process utilized and the scaffolds produced have potential for use in tissue engineering and regenerative medicine applications.

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Irradiation effects on polycaprolactone

Cited by 86 publications

References 10 publications

The influence of freeze drying and &upsih;-irradiation in pre-clinical studies of flurbiprofen polymeric nanoparticles for ocular delivery using D-(+)-trehalose and polyethylene glycol

The influence of freeze drying and &upsih;-irradiation in pre-clinical studies of flurbiprofen polymeric nanoparticles for ocular delivery using D-(+)-trehalose and polyethylene glycol

Effect of sterilisation by gamma irradiation on the ability of polycaprolactone (PCL) to act as a scaffold material

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization

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