Irregular cycles and steroid hormones in polycystic ovary syndrome

Doi, Suhail A.R.; Al-Zaid, Mona; Towers, Philip A.; Scott, Christopher J.; Al-Shoumer, Kamal A.S.

doi:10.1093/humrep/dei093

Cited by 45 publications

(29 citation statements)

References 63 publications

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“…This profile suggests an increased steroidogenic activity, which is widely described in PCOS (Franks et al 2000, Abbott et al 2002. Evidence shows that follicles from anovulatory women with PCOS hypersecrete E when compared with size-matched follicles from normal ovaries or polycystic ovaries from ovulatory women (Franks et al 2000, Mendonca et al 2004, Doi et al 2005. These findings also support those of the current study.…”

Section: Discussionsupporting

confidence: 91%

Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone

Sander¹,

Luchetti²,

Solano³

et al. 2006

Reproduction

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The present study investigated the role of the N, N{ 0 }-dimethylbiguanide metformin (50 mg/100 g body weight in 0.05 ml water, given orally with a canulla) in the prevention of endocrine and immune disorders provoked by the hyperandrogenization with dehydroepiandrosterone (DHEA) in prepuberal BALB/c mice. The treatment with DHEA (6 mg/100 g body weight in 0.1 ml oil) for 20 consecutive days, recreates a mouse model that resembles some aspects of the human polycystic ovary syndrome (PCOS). The treatment with DHEA did not modify either body mass index (BMI) or blood glucose levels, but did increase fasting insulin levels when compared with controls. Markers of ovarian function -serum estradiol (E), progesterone (P) and ovarian prostaglandin E (PGE) -were evaluated. The treatment with DHEA increased serum E and P levels while ovarian PGE diminished. When metformin was administered together with DHEA, serum insulin, E and P levels, and ovarian PGE values did not differ when compared with controls. Using flow cytometry assays we found that the treatment with DHEA diminished the percentage of the CD4 1 T lymphocyte population and increased the percentage of the CD8 1 T lymphocyte population from both ovarian tissue and retroperitoneal lymph nodes. However, when metformin was administered together with DHEA, the percentages of CD4 1 and CD8 1 T lymphocyte populations from both ovarian tissue and retroperitoneal lymph nodes were similar to those observed in controls. Finally, when DHEA was administered alone it increased the serum tumor necrosis factor-alpha (TNF-a) levels when compared with controls; however, when metformin was administered together with DHEA, serum TNF-a levels were similar to controls. These results indicate that metformin is able, directly or indirectly, to avoid the endocrine and immune alterations produced when mice are hyperandrogenized with DHEA.

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Section: Discussionsupporting

confidence: 91%

Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone

Sander¹,

Luchetti²,

Solano³

et al. 2006

Reproduction

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show abstract

“…According to its pathophysiology, PCOS is manifested clinically by both a hyperandrogenism and state of estrogen Results of c 2 test (linear-by-linear association) and logistic regression in rates of ovulation and pregnancy for groups A, B, C, and D. excess, which can underlie a disorder of folliculogenesis with increased follicular recruitment, but with an arrest of follicular development at the small antral stage (13). Theoretically, the ovarian interstitial laser treatment should be more effective than laparoscopic ovarian diathermy in management of anovulation in PCOS.…”

Section: Discussionmentioning

confidence: 99%

Transvaginal ultrasound-guided ovarian interstitial laser treatment in anovulatory women with polycystic ovary syndrome: a randomized clinical trial on the effect of laser dose used on the outcome

Zhu

Chen

et al. 2010

Fertility and Sterility

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“…Other epidemiologic studies found the risk of UL to be positively associated with medication-treated diabetes (20) and hypertension (20,21), conditions that are associated with PCOS (9). Finally, PCOS was associated with a high ratio of E 2 to P (22), which may be an important mechanism by which PCOS affects the risk of UL. Thus, PCOS may influence the development of UL via elevation of LH levels, dysregulation of the IGF-GH axis, and/or increased levels of unopposed estrogens.…”

mentioning

confidence: 89%

Polycystic ovary syndrome and risk of uterine leiomyomata

Wise

Palmer

Stewart

et al. 2007

Fertility and Sterility

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Irregular cycles and steroid hormones in polycystic ovary syndrome

Abstract: The results suggest that a low ratio of progesterone to E(2) is associated with menstrual irregularity and ovulatory status in PCOS.

Cited by 45 publications

References 63 publications

Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone

Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone

Transvaginal ultrasound-guided ovarian interstitial laser treatment in anovulatory women with polycystic ovary syndrome: a randomized clinical trial on the effect of laser dose used on the outcome

Polycystic ovary syndrome and risk of uterine leiomyomata

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