Irregular textural features of dried alginate–filler beads

Zohar‐Perez, Cheinat; Chet, I.; Nussinovitch, A.

doi:10.1016/s0268-005x(03)00081-x

Cited by 63 publications

(27 citation statements)

References 27 publications

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“…Besides, the pH of the release medium had an effect on the drug release from AL beads, and a long-term hypoglycemic effect was observed in diabetic rats after oral administration of AL-and AL-CS-beads. The ALand AL-CS-beads shrunk after freeze-drying, which is similar to the results reported by ZoharPerez et al [30]. There was a slight but insignificant difference between particle sizes of the blank and drug-loaded AL and AL-CS beads, indicating that the presence of chitosan and incorporation of metformin HCl into the beads did not influence the particle size.…”

Section: Discussionsupporting

confidence: 88%

In vitro and in vivo evaluation of alginate and alginatechitosan beads containing metformin hydrochloride

Mokhtare¹,

Çetin²,

Özakar³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 88%

In vitro and in vivo evaluation of alginate and alginatechitosan beads containing metformin hydrochloride

Mokhtare¹,

Çetin²,

Özakar³

et al. 2017

Trop. J. Pharm Res

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“…The lyophilization process induced a deformation tin the structure of the granules caused by the sublimation of the water from the hydrogel matrix. This fact resulted in granules with an unpredictable and irregular shape, occurrence observed in former studies (Chan et al 2011b;Rassis et al 2002;Zohar-Perez et al 2004). Nevertheless, in our study, the deformation of the granules was attenuated by Fig.…”

Section: Granules Size and Shapesupporting

confidence: 56%

The influence of different polymers on viability of Bifidobacterium lactis 300b during encapsulation, freeze-drying and storage

Pop

Brandau²,

Schwinn³

et al. 2014

J Food Sci Technol

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Seven different types of natural polymers namely hydroxypropyl methylcellulose (HPMC), sodiumcarboxymethyl cellulose (Na-CMC), microcrystalline cellulose (MCC), starch BR-07, starch BR-08, dextrin and pullulan were used in order to develop the optimal formula for the entrapment of Bifidobacterium lactis 300B in Ca-alginate based granules. Laminar flow drip casting with Brace-Encapsulator was used in order to prepare the granules. The results showed that alginate/ pullulan and alginate/HPMC formulation provide high protection for the bacterial strain used for encapsulation. These two formulations were further used to obtain freeze dried granules, for which the viability in time and at different temperatures was tested. The final results showed a higher viability than the level of the therapeutic minimum (>10 7 CFU/g) after 15 days of storage. Other parameters like entrapment efficiency, production rate, sphericity, flowability were also discussed.

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“…These craters may have been a result of processing, that is, freezing in the case of drying by freeze-dehydration. This was previously explained, 20 taking into consideration the size of the filler itself. [21][22][23] Addition of filler to the formulation contributed to a decrease in the number of the craters (see Fig.…”

Section: Resultsmentioning

confidence: 97%