2023
DOI: 10.21203/rs.3.rs-2689241/v1
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Irreversible atrophy in memory brain regions over 7 years is predicted by glycemic control in type 2 diabetes without cognitive decline

Abstract: Memory-related impairments in type 2 diabetes maybe be mediated by insulin resistance and hyperglycemia. Previous cross-sectional studies have controversially suggested a relationship between metabolic control and a decrease in hippocampal volumes, but only longitudinal studies can test this hypothesis directly. We performed a longitudinal morphometric study to provide such a direct test of a possible role of higher levels of glycated hemoglobin (HbA1C) with long term brain structural integrity in key regions … Show more

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