2015
DOI: 10.12659/msm.894365
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Is Alpha-1 Antichymotrypsin Gene Polymorphism a Risk Factor for Primary Intracerebral Hemorrhage? A Case-Control Study and Meta-Analysis

Abstract: BackgroundAlpha-1 antichymotrypsin (ACT) signal peptide A/T polymorphism has been suggested to play a role in various brain diseases with arterial wall pathology. We conducted a case-control study and a meta-analysis to evaluate the association between this polymorphism and risk of primary intracerebral hemorrhage.Material/MethodsA total of 188 patients and 200 age- and sex-matched healthy controls were enrolled in our case-control study. The ACT polymorphism was genotyped by PCR-LDR. Further meta-analysis was… Show more

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Cited by 2 publications
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“…DNA was isolated from peripheral whole blood using the DNA Blood Kit (Bioteke Corp., China). The C677T polymorphism was genotyped by the polymerase chain reaction- ligase detection reaction (PCR-LDR) sequencing method, as described previously [ 21 ]. Briefly, the PCR primers used were: 5′-AGGCCAGCCTCTCCTGACTGT-3′ (forward) and 5′-CCATGTCGGTGCATGCCTTCA-3′ (reverse).…”
Section: Methodsmentioning
confidence: 99%
“…DNA was isolated from peripheral whole blood using the DNA Blood Kit (Bioteke Corp., China). The C677T polymorphism was genotyped by the polymerase chain reaction- ligase detection reaction (PCR-LDR) sequencing method, as described previously [ 21 ]. Briefly, the PCR primers used were: 5′-AGGCCAGCCTCTCCTGACTGT-3′ (forward) and 5′-CCATGTCGGTGCATGCCTTCA-3′ (reverse).…”
Section: Methodsmentioning
confidence: 99%