Is an anodizing coating associated to the photobiomodulation able to optimize bone healing in ovariectomized animal model?

Polo, Tárik Ocon Braga; Momesso, Gustavo Antônio Corrêa; Silva, William Phillip Pereira; Santos, Anderson Maikon de Souza; Santos, João Matheus Fonseca e; Cruz, Nilson Cristino da; Barão, Valentim A. R.; Garcia, Valdir Gouveia; Theodoro, Letícia Helena; Faverani, Leonardo Pérez

doi:10.1016/j.jphotobiol.2021.112167

Cited by 3 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The animal model proposed in this study is already well-established in the literature for evaluating effects on peri-implant repair. 26 , 36 - 38 Ovariectomy induces a significant reduction in estrogen levels, simulating a condition similar to menopause and post-menopause in women. 9 , 10 Hormonal suppression results in decreased osteoblast activity and an increase in bone reabsorption by osteoclasts, ultimately leading to reduced bone density and subsequent bone mineral loss.…”

Section: Discussionmentioning

confidence: 99%

Ozone therapy improves early stages of osseointegration in ovariectomized rats

SILVA,

SANTOS,

SOUZA

et al. 2024

J. Appl. Oral Sci.

Self Cite

View full text Add to dashboard Cite

Objective the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats. Methodology ovariectomy was performed on 30 Wistar rats, aged six months (Rattus novergicus), and, after 90 days, osseointegrated implants were installed in each tibial metaphysis. The study groups were divided into the animals that received intraperitoneal ozone at a concentration of 700 mcg/kg — OZ Group (n=15) — and a control group that received an intraperitoneal saline solution and, for this reason, was named the SAL group (n=15). The applications for both groups occurred during the immediate post-operative period on the 2nd, 4th, 6th, 8th, 10th, and 12th day post-surgery. At various stages (14, 42, and 60 days), the animals were euthanized, and tests were performed on their tibiae. These tests include histomorphometric and immunohistochemical analyses, computerized microtomography, sampling in light-cured resin for calcified sections, and confocal microscopy. The obtained data were then analyzed using One-way ANOVA and the Shapiro-Wilk, Kruskal-Wallis, and student t-tests (P<0.05). Results our findings indicate that the OZ group (3.26±0.20 mm) showed better cellular organization and bone neoformation at 14 days (SAL group, 0.90±1.42 mm) (P=0.001). Immunohistochemistry revealed that osteocalcin labeling was moderate in the OZ group and mild in the SAL group at 14 and 42 days post-surgery. The data from the analysis of calcified tissues (microtomography, histometric, and bone dynamism analysis) at 60 days showed no statistically significant differences between the groups (P=0.32). Conclusion it was concluded that ozone therapy anticipated the initial phases of the peri-implant bone repair process.

show abstract