Is antibiotic prophylaxis still mandatory for transperineal prostate biopsy? Results of a comparative study

Transperineal US-MRI Fusion-Guided Biopsy for the Detection of Clinical Significant Prostate Cancer: A Systematic Review and Meta-Analysis Comparing Cognitive and Software-Assisted Technique

“…In fact, the TP route seems to allow a better prostate sampling, including in the anterior zone, and is associated with a higher PCa detection rate compared to the TR one as shown in a recent multicentric study [ 28 ], with a reduced number of complications, particularly infectious [ 29 ]. Recent studies also outlined the feasibility of TP-PB without the use of prophylactic antibiotics [ 30 , 31 ], thus providing a further drive for the adoption of the TP approach with the purpose of minimizing the problem of antibiotic resistances.…”

Detection of anterior prostate cancer using a magnetic resonance imaging-transrectal ultrasound fusion biopsy in cases with initial biopsy and history of systematic biopsies

“…Although the transrectal approach is more commonly used because it can be performed easily at the bedside without lumbar anesthesia, it has been demonstrated that the transperineal approach is more effective in detecting anterior lesions and has fewer complications of infection. 4 , 7 , 14 , 24 , 28 Thus, since biopsy approaches vary among institutions, pre-biopsy MRI should be performed actively to screen for anterior lesions before a transrectal biopsy is performed.…”

Molecular genetic testing does not improve the detection of fluoroquinolone resistance before transrectal prostate biopsy

“…Transrectal ultrasound-guided prostate needle biopsy (TPB) remains the most common technique to diagnose prostate cancer. 1 , 2 Traditionally, TPB has a low infection risk when performed using recommended fluoroquinolone prophylaxis; 3 however, rates of post-TPB infection have steeply risen over the last decade to over 10% in some series. 4 Previous studies have linked infections to colonization status of fluoroquinolone-resistant (FQR) Escherichia coli ( E. coli ) identified in asymptomatic individuals prompting alternate prophylaxis regimens.…”