Is Betahistine Effective in the Treatment of Ménière's Disease?

Holmes, Sean; Lalwani, Anil K.; Mankekar, Gauri

doi:10.1002/lary.29535

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Betahistine, a structural analog of histamine, is a weak H 1 R agonist and a strong H 3 R antagonist [64,80]. It is used to treat Ménière's disease, particularly in central Europe [78].…”

Section: Clinical Applicationmentioning

confidence: 99%

Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review

2023

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Background: Histamine is a widely distributed biogenic amine with multiple biological functions mediated by specific receptors that determine the local effects of histamine. This review aims to summarize the published findings on the expression and functional roles of histamine receptors in the inner ear and to identify potential research hotspots and gaps. Methods: A search of the electronic databases PubMed, Web of Science, and OVID EMBASE was performed using the keywords histamine, cochlea*, and inner ear. Of the 181 studies identified, 18 eligible publications were included in the full-text analysis. Results: All four types of histamine receptors were identified in the mammalian inner ear. The functional studies of histamine in the inner ear were mainly in vitro. Clinical evidence suggests that histamine and its receptors may play a role in Ménière’s disease, but the exact mechanism is not fully understood. The effects of histamine on hearing development remain unclear. Conclusions: Existing studies have successfully determined the expression of all four histamine receptors in the mammalian inner ear. However, further functional studies are needed to explore the potential of histamine receptors as targets for the treatment of hearing and balance disorders.

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“…Betahistine, a structural analog of histamine, is a weak H 1 R agonist and a strong H 3 R antagonist [64,80]. It is used to treat Ménière's disease, particularly in central Europe [78].…”

Section: Clinical Applicationmentioning

confidence: 99%

Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review

2023

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Betahistine in the treatment of peripheral vertigo: an evidence-based review

Silva Gameiro,

Silva Fonseca,

Guimarães

et al. 2024

Egypt J Otolaryngol

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Background Vertigo is a common presenting symptom in clinical practice, predominantly of vestibular etiology, and often medicated with betahistine, despite the lack of knowledge concerning its mechanism of action. This paper’s objective was to review the scientific evidence regarding the efficacy of betahistine on peripheral vertigo. Methods A systematic search of articles written in English, published within the past 10 years, was conducted in April 2024, on online evidence-based medicine databases, using the MeSH terms “betahistine,” “ménière disease,” “acute vestibular neuritis,” “paroxysmal vertigo,” “acute peripheral vestibulopathy,” and “labyrinthitis.” The Strength of Recommendation Taxonomy of the American Academy of Family Physicians was used to evaluate the level of evidence and strength of recommendation. Results This review included 12 articles for evidence analysis. Concerning Menière’s disease, despite contradictory results, three of the articles analyzed showed a positive effect of betahistine, which is in line with the recommendations of the European Academy of Otology and Neurotology and NICE guidelines, while the American Academy of Otorhinolaryngology guidelines suggest offering betahistine as maintenance therapy. For benign paroxysmal positional vertigo, the established treatment is repositioning maneuvers, and three of the five studies analyzed proved the addition of betahistine to be beneficial. In regard to peripheral vertigo from other causes, two out of three articles revealed a positive recommendation for the use of betahistine. Conclusion There is a potential benefit to the utilization of betahistine for various etiologies of peripheral vertigo. However, additional studies are required to establish more robust evidence.

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Is Betahistine Effective in the Treatment of Ménière's Disease?

Cited by 2 publications

References 6 publications

Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review

Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review

Betahistine in the treatment of peripheral vertigo: an evidence-based review

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