Is choroidal vascularity index a useful marker in different stages of idiopathic epiretinal membranes?

Gediz, Berrak Şekeryapan; Doğuizi, Sibel; Ozen, Osman; Şekeroğlu, Mehmet Ali

doi:10.1016/j.pdpdt.2020.102110

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…The relationship between the iERM and choroidal thickness has not been determined. Some studies have found that the thickness of the iERM with traction is greater than that of the normal control group [29], but many studies have not found a relationship between the iERM and choroidal thickness [27,28,30]. Our results show that choroidal thickness in patients with IMH is lower than that in patients with ERM, with comparable ages and axial lengths, which is consistent with previous results.…”

Section: Discussionsupporting

confidence: 90%

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Comparison of the morphological characteristics of the choroidal sublayer between idiopathic macular holes and epiretinal membranes with automatic analysis

zhang

Zhang

et al. 2023

Preprint

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Purpose To compare the choroidal sublayer morphologic features between idiopathic macular hole (IMH) and idiopathic epiretinal membrane (iERM) on spectral-domain optical coherent tomography (SD-OCT) using an automatic segmentation model. Methods: Thirty-three patients with idiopathic IMHs and 44 with iERMs who underwent vitrectomies were involved. The enhanced depth imaging mode of SD-OCT was used to obtain the B-scan image after single line scanning of the macular fovea. The choroidal sublayer automatic analysis model divides the choroidal into the choroidal large vessel layer, the middle vessel layer and the small vessel layer (LVCL, MVCL and SVCL, respectively) and calculates the choroidal thickness (overall, LVCL, MVCL and SVCL) and vascular index (overall, LVCL, MVCL and SVCL). The morphological characteristics of the choroidal sublayer in the ERM eyes and the IMH eyes were compared. Results: The mean choroidal thickness in the macular centre of the IMH eyes was significantly thinner than that of the ERM eyes (206.35 ± 81.72 vs. 273.33 ± 82.31 μm; P<0.001). The analysis of the choroidal sublayer showed that the MVCL and SVCL macular centres and 0.5-1.5 mm of the nasal and temporal macula were significantly thinner in the IMH eyes than in the ERM eyes (P < 0.05), and there was a difference in the macular centre of the LVCL between the two groups (P < 0.05). In contrast, the choroidal vascular index of the macular centre in the IMH eyes was significantly higher than that in iERM eyes (0.2480 ± 0.0536 vs. 0.2120 ± 0.0616; P < 0.05). There was no significant difference in the CVI of other parts of the macula, the LVCL or MVCL between the two groups. Conclusion: The choroidal thickness of the IMH eyes was significantly thinner than that of the iERM eyes, which was mainly observed in 3 mm of the macular centre and the MVCL and SVCL layers of the choroid. The choroidal vascular index of the IMH eyes was higher than that of the iERM eyes. These findings suggest that the choroid may be involved in the pathogenesis of IMH and iERM.

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Section: Discussionsupporting

confidence: 90%

“…Studies have found that the choroidal thickness of the iERM with contraction is signi cantly thickened [29]. Other studies found that there was no signi cant change in the CVI in iERM patients [30]. These studies show that the choroid is involved in the occurrence and development of an IMH and the iERM.…”

Section: Introductionmentioning

confidence: 60%

Comparison of the morphological characteristics of the choroidal sublayer between idiopathic macular holes and epiretinal membranes with automatic analysis

zhang

Zhang

et al. 2023

Preprint

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“…Gediz et al 35 noted a positive correlation between CVI and neutrophil-to-lymphocyte ratio, suggesting that CVI was a potential inflammatory biomarker. Graves’ ophthalmopathy, or thyroid eye disease, is regarded as an inflammatory disease that occurs as a result of autoimmune thyroid disease.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of choroidal circulation and stromal features in Graves’ disease

Aksoy

Şimşek

Apaydın

2021

European Journal of Ophthalmology

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Purpose: This study aimed to evaluate choroidal thickness (CT) and choroidal vascularity index (CVI) in patients with Graves’ disease (GD) without ocular involvement. Methods: Fifty patients diagnosed with GD and 50 age and gender matched healthy control subjects were retrospectively evaluated. Measurements were taken from five different points on CT images. Choroid images were classified as lumen regions (LA) and stromal regions (SA) using the image binarization method. CVI was calculated by dividing LA by the total choroidal area (TCA). The effects of Thyrotropin Receptor Antibody (TRAb), age, GD duration, blood pressure, axial length measurements, and intraocular pressure were analyzed on CT and CVI measurements. Results: Mean age was 40.1 ± 13.5 years in the patient group and 39.3 ± 13.6 years in the control group ( p = 0.89). There was no significant difference between the GD group and control group in terms of CT measurements. There was a significant difference between the mean CVI measurements of the GD group and control group (68.03 ± 3.41 and 66.62 ± 3.11, respectively) ( p < 0.001). Univariate linear regression analysis revealed a positive correlation between TRAb and CVI ( p = 0.013). Conclusion: While there was no significant difference between the CT measurements of the GD group and the control group, the GD group had significantly higher CVI measurements.

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confidence: 99%

“…6 In numerous further studies, Agarwal et al and other groups have studied CVI and its potential applications in the evaluation and management of many disease states including hereditary disease. [7][8][9][10][11] In particular, it has been found that patients with acute central serous chorioretinopathy (CSC) have higher CVI compared with those with resolved disease and normal healthy patients. 12 However, CVI alone may not be enough to represent all subtle changes in choroidal architecture or function in CSC, demonstrated, for example, by only limited changes in these metrics found after treatment.…”

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confidence: 99%

Image Analysis of Optical Coherence Tomography Scans to Explore Established and Novel Choroidal Features in Patients With Central Serous Chorioretinopathy

Aslam

Chhabra

Agrawal

et al. 2022

Retina

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Purpose: To explore the characteristics of choroidal tissue in patients with and without central serous chorioretinopathy (CSC) using an automated system of image analysis to determine known and novel metrics.Methods: This was a retrospective case-control analysis of optical coherence tomography scans of patients seen at Manchester Royal Eye Hospital, UK, comparing patients with active CSC to an age-matched and gender-matched group with no CSC using a purpose-built automated system of image analysis. The expert system segments and measures established and novel features of choroid using a combination of thresholding, noise removal, and morphological techniques.Results: A total of 72 patients were included in this study, with 40 included in the group with CSC and 32 patient controls with no CSC. There were significant increases from normal to CSC of median choroidal vascularity index, 54.7(median absolute deviation = 9.8) to 61.2(4.3), and all choroidal thickness indices including maximum depth, from 249.0(90.1) mm to 372.3(80.3) mm. For novel measures, there was a significant increase in tissue entropy from 6.68(0.28) to 6.95(0.17) and area of the largest five vessels from 6.28(3.04) mm 2 to 9.10(3.49) mm 2 . The ratio of vessel lumen to stromal tissue intensity was conversely significantly reduced from 0.674(0.11) in normal patients to 0.59(0.06) in CSC.Conclusion: The automated system of choroidal analysis expands on the utility of known measures and introduces novel metrics. These findings contribute pathophysiological insights and metrics for further assessment and research on conditions affecting choroidal tissue.

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Is choroidal vascularity index a useful marker in different stages of idiopathic epiretinal membranes?

Cited by 9 publications

References 28 publications

Comparison of the morphological characteristics of the choroidal sublayer between idiopathic macular holes and epiretinal membranes with automatic analysis

Comparison of the morphological characteristics of the choroidal sublayer between idiopathic macular holes and epiretinal membranes with automatic analysis

Evaluation of choroidal circulation and stromal features in Graves’ disease

Image Analysis of Optical Coherence Tomography Scans to Explore Established and Novel Choroidal Features in Patients With Central Serous Chorioretinopathy

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