Is community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) an emerging pathogen among children in Brazil?

Ossa, Rolando Paternina-de la; Prado, Sara Noéme; Cervi, Maria Célia; Lima, Denissani Aparecida Ferrari dos Santos; Martínez, Roberto; Bellissimo-Rodrigues, Fernando

doi:10.1016/j.bjid.2018.10.276

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…In contrast, all the MRSA isolates tested were susceptible to linezolid and vancomycin, as observed in other Brazilian studies [51][52][53][54] . Currently, resistance to oxazolidinones (including linezolid) among S. aureus is rare, whereas prolonged exposure to vancomycin leads to the emergence of MRSA with reduced vancomycin susceptibility, and the strains are categorized as vancomycin-intermediate S. aureus (VISA) and heterogeneous VISA (hVISA) 55 , as reported in other studies conducted in Brazil .…”

Section: Discussionsupporting

confidence: 81%

Resistance profile to antimicrobials agents in methicillin-resistant Staphylococcus aureus isolated from hospitals in South Brazil between 2014-2019

Rossato

Primon-Barros

Rocha

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen causing healthcare-associated infections. Owing to the restricted use of beta-lactams in MRSA infections, non-beta-lactam antimicrobials are required for treatment. However, MRSA can develop resistance mechanisms to non-beta-lactam antimicrobials, which reduces viable treatment options. Here, we evaluated the antimicrobial susceptibility and resistance genes of MRSA isolated from hospitalized patients in South Brazil. Methods: The antimicrobial susceptibilities of hospital MRSA (217) isolates were determined by disk diffusion or microdilution methods. Additionally, the presence of 14 resistance genes and SCCmec typing was performed by PCR. Results: Among the antimicrobials tested, we observed high erythromycin (74.2%), ciprofloxacin (64.5%), and clindamycin (46.1%) resistance rates and complete susceptibility to linezolid and vancomycin. Seventeen different patterns of MRSA antimicrobial resistance were observed, of which 42.9% represented multidrug resistance. Among erythromycin-resistant MRSA, 53.4%, 45.3%, 37.9%, 13.0%, and 6.8% carried ermA, msrA, msrB, ermC, and ermB genes, respectively. Among clindamycin-resistant MRSA, 83%, 17%, 10%, 4%, and 2% carried ermA, ermC, ermB, linA, and linB genes, respectively. Among gentamicin-resistant MRSA, 96.8%, 83.9%, and 9.7% carried aac(6')/aph(2''), aph(3')-IIIa, and ant(4')-Ia genes, respectively. Among tetracycline-resistant MRSA, 6.5% and 93.5% carried tetK and tetM genes, respectively. Lastly, among trimethoprim/sulfamethoxazole-resistant MRSA, 13.3% and 100% carried dfrA and dfrG genes, respectively. The SCCmec type IV isolates were detected more frequently, whereas the SCCmec type III isolates exhibited higher multidrug resistance. Conclusions: The study data provides information regarding the MRSA resistance profile in South Brazil that is associated with the clinical conditions of patients and can contribute to clinical decision-making.

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Section: Discussionsupporting

confidence: 81%

Resistance profile to antimicrobials agents in methicillin-resistant Staphylococcus aureus isolated from hospitals in South Brazil between 2014-2019

Rossato

Primon-Barros

Rocha

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…The parameters used in the model are shown in Table 1. 17,28,[32][33][34][35][36][37][38][39][40][41][42][43] The results of the dynamic transmission model for the 2 health outcomes of interest (avoided cases of patients with resistant infection and avoided deaths), for infections caused by any of the 3 microorganisms evaluated, are shown in Appendix Table 5 in Appendix Section 3 in Supplemental Materials found at https://doi. org/10.1016/j.vhri.2021.07.009.…”

Section: Resultsmentioning

confidence: 99%

Cost-Effectiveness of Molecular Method Diagnostic for Rapid Detection of Antibiotic-Resistant Bacteria

Salvador

Lucchetta

Sarti

et al. 2022

Value in Health Regional Issues

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“… 17 In Brazil, two studies conducted in the state of São Paulo showed methicillin-resistance rates of 20%–45% in pediatric OAI. 18 , 19 Additionally, the detection of toxin-producing strains, such as those that produce Panton–Valentine leukocidin, which can lead to more severe cases with sepsis, shock, and even death, are also a matter of concern. For this reason, knowledge of the local resistance profile of this microorganism is extremely important for determining the best empirical antibiotic therapy regimen for OAI.…”

Section: Etiologymentioning

confidence: 99%

Osteoarticular infections in pediatrics

Alvares¹,

Mimica

2020

Jornal de Pediatria

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Is community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) an emerging pathogen among children in Brazil?

Cited by 8 publications

References 27 publications

Resistance profile to antimicrobials agents in methicillin-resistant Staphylococcus aureus isolated from hospitals in South Brazil between 2014-2019

Resistance profile to antimicrobials agents in methicillin-resistant Staphylococcus aureus isolated from hospitals in South Brazil between 2014-2019

Cost-Effectiveness of Molecular Method Diagnostic for Rapid Detection of Antibiotic-Resistant Bacteria

Osteoarticular infections in pediatrics

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