2013
DOI: 10.1161/hypertensionaha.113.01853
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Is Creatine Kinase the Intrinsic Factor of Smooth Muscle Enhancing Vascular Contractility in Subjects of African Ancestry?

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Cited by 3 publications
(2 citation statements)
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“…Dr Karamat et al 1 raise the interesting hypothesis that increased vascular smooth muscle reactivity in subjects of African ancestry may be related to greater activity of the enzyme creatine kinase in vascular muscle cells. Our study was not designed to elucidate the biochemical mechanisms of ethnic differences in vascular reactivity, but it is nevertheless interesting to consider our findings with the creatine kinase hypothesis in mind.…”
mentioning
confidence: 99%
“…Dr Karamat et al 1 raise the interesting hypothesis that increased vascular smooth muscle reactivity in subjects of African ancestry may be related to greater activity of the enzyme creatine kinase in vascular muscle cells. Our study was not designed to elucidate the biochemical mechanisms of ethnic differences in vascular reactivity, but it is nevertheless interesting to consider our findings with the creatine kinase hypothesis in mind.…”
mentioning
confidence: 99%
“…Indivíduos de raça preta* 1 apresentam artérias com menor capacidade de dilatação a estímulos vasodilatatórios e maior capacidade de contração a estímulos agonistas de CMLV (81-83), além de maior rigidez arterial proximal em relação a indivíduos brancos (80,84). Existe a hipótese de que o aumento da atividade de enzima creatino-quinase (CK) nas CMLV responda por parte das alterações encontradas (85).…”
Section: Ancestralidade Racialunclassified