2020
DOI: 10.3389/fimmu.2020.567710
|View full text |Cite
|
Sign up to set email alerts
|

Is Cross-Reactive Immunity Triggering COVID-19 Immunopathogenesis?

Abstract: The serological responses to both SARS-CoV-1 and SARS-CoV-2 virus have some unique characteristics that suggest cross-reactive priming by other human coronaviruses (hCoVs). The early kinetics and magnitude of these responses are, in some cases, associated with worse clinical outcomes in SARS and COVID-19. Cross-reactive hCoV antibody responses have been detected in both SARS and COVID-19 patients. There is also evidence that pre-existing T cell immunity to common cold coronaviruses can prime the response to SA… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
56
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 63 publications
(59 citation statements)
references
References 78 publications
3
56
0
Order By: Relevance
“…Our study was performed on the cohort of 47 patients, thus more detailed information for cross-coronaviral immunity against different strains is needed. However, after the current report was published as preprint (Rabets et al 2020 ), there were a series of works confirming our idea, that humoral cross-coronaviral immunity is important in defining COVID (Beretta et al 2020 ; Lipsitch et al 2020 ; Yaqinuddin 2020 ).…”
Section: Discussionsupporting
confidence: 64%
“…Our study was performed on the cohort of 47 patients, thus more detailed information for cross-coronaviral immunity against different strains is needed. However, after the current report was published as preprint (Rabets et al 2020 ), there were a series of works confirming our idea, that humoral cross-coronaviral immunity is important in defining COVID (Beretta et al 2020 ; Lipsitch et al 2020 ; Yaqinuddin 2020 ).…”
Section: Discussionsupporting
confidence: 64%
“…Incidentally, TMPRSS2 has been the target of influenza viruses; the hemagglutinin protein of these viruses contains a monobasic cleavage site for TMPRSS2. It is also shown to modify and trigger the F protein of human metapneumovirus, thus numerous respiratory viral pathogens pirate TMPRSS2 and other proteins to promote their virulence [ 22 ].…”
Section: Resultsmentioning
confidence: 99%
“…Nevertheless, skepticism about vaccines and their potential side effects are widespread, resulting in vaccine hesitancy [13]. One of the potentially negative effects of December 29, 2020 2/14 a vaccine is the occurrence of antibody-dependent enhancement (ADE) or, more general, enhanced respiratory disease (ERD) [14,15]. ADE is best understood in Dengue fever and was observed also in SARS-CoV and MERS-CoV both in vitro and in vivo [16].…”
Section: Russia Was Ambitious To Release the World's First Sars-cov-2mentioning
confidence: 99%
“…Incentives for getting voluntary vaccines have been proposed, e.g., recently Qantas airlines announced to make the vaccine mandatory for their passengers [11,12]. a vaccine is the occurrence of antibody-dependent enhancement (ADE) or, more general, enhanced respiratory disease (ERD) [14,15]. ADE is best understood in Dengue fever and was observed also in SARS-CoV and MERS-CoV both in vitro and in vivo [16].…”
Section: Russia Was Ambitious To Release the World's First Sars-cov-2mentioning
confidence: 99%