Is Curcumin the Answer to Future Chemotherapy Cocktail?

Kong, Wei Yang; Ngai, Siew Ching; Goh, Bey Hing; Lee, Learn‐Han; Htar, Thet Thet; Chuah, Lay Hong

doi:10.3390/molecules26144329

Cited by 24 publications

(15 citation statements)

References 198 publications

(255 reference statements)

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“…It may also target CSCs in esophageal carcinoma [ 224 ], hepatocellular carcinoma [ 225 ], and glioma [ 223 ]. Curcumin makes cancer cells more vulnerable to chemotherapeutic agents (doxorubicin, paclitaxel, 5-fluorouracil, and cisplatin) [ 226 , 227 , 228 , 229 ] and radiotherapy [ 230 , 231 ].…”

Section: Plants From Different Continents Used In Ethnomedicine For T...mentioning

confidence: 99%

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

et al. 2022

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Traditional herbal medicine (THM) is a “core” from which modern medicine has evolved over time. Besides this, one third of people worldwide have no access to modern medicine and rely only on traditional medicine. To date, drugs of plant origin, or their derivates (paclitaxel, vinblastine, vincristine, vinorelbine, etoposide, camptothecin, topotecan, irinotecan, and omacetaxine), are very important in the therapy of malignancies and they are included in most chemotherapeutic regimes. To date, 391,000 plant and 14,000 mushroom species exist. Their medical and biochemical capabilities have not been studied in detail. In this review, we systematized the information about plants and mushrooms, as well as their active compounds with antitumor properties. Plants and mushrooms are divided based on the regions where they are used in ethnomedicine to treat malignancies. The majority of their active compounds with antineoplastic properties and mechanisms of action are described. Furthermore, on the basis of the available information, we divided them into two priority groups for research and for their potential of use in antitumor therapy. As there are many prerequisites and some examples how THM helps and strengthens modern medicine, finally, we discuss the positive points of THM and the management required to transform and integrate THM into the modern medicine practice.

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Section: Plants From Different Continents Used In Ethnomedicine For T...mentioning

confidence: 99%

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

et al. 2022

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“…17) in silver sulfadiazine nanoliposomes, developing a photo-activable antimicrobial system, efficient against A. baumannii [105] . Curcumin is a natural PS, extracted from the root of the turmeric plant, and with a strong background in traditional Asian medicine, supported with increasing evidence of a wide range of therapeutic effects [106] . In this case, the curcumin-loaded nanoparticles showed negligible toxicity against eukaryotic cells, while efficiently photoeradicating A. baumannii.…”

Section: Micelles Liposomes Vesicles and Microemulsionsmentioning

confidence: 99%

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

Maldonado-Carmona

Ouk

Leroy‐Lhez

2021

Photochem Photobiol Sci

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“…The antimicrobial effects of curcumin have been determined previously [ 15 , 16 ]. Also, combination anticancer therapies using curcumin-silybin has been demonstrated before [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of silybin and curcumin on virulence and carbapenemase genes expression in multidrug resistant Klebsiella oxytoca

et al. 2022

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Objective Silybin and curcumin have potential antimicrobial effects. This study aimed to evaluate the synergistic antimicrobial effects of silybin and curcumin on virulence and carbapenemase genes expression among multidrug-resistant (MDR) Klebsiella oxytoca. Results A total of 70 MDR K. oxytoca (carrying blaIMP and blaOXA-48-like genes) were included. The antibiotic susceptibility and biofilm production of isolates were determined. The silybin and curcumin at concentrations 10–500 mg/mL alone and in combination were exposed to bacterial isolates in Mueller Hinton broth medium for 24 h. The expression of blaIMP, blaOXA-48-like, mrkA, pilQ, matB and fimA genes was evaluated using quantitative real-time polymerase chain reaction (qRT-PCR). The mean minimum inhibitory concentration (MIC) of curcumin and silybin were 250 mg/mL and 500 mg/mL, respectively. The anti-virulent effect of 100 mg/mL of silybin and curcumin was shown by significant reduction in the expression of fimA (2.1-fold, P < 0.0001) and mrkA (2.1 fold, P < 0.0001) genes. Moreover, these compounds significantly decreased the expression of blaIMP1 (3.2-fold, P < 0.0001) gene. Notably, there was no significant effect on pilQ, matB and blaOXA-48-like genes. The results showed that silybin and curcumin can be candidate as natural way for control the MDR virulent strains of K. oxytoca.

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Is Curcumin the Answer to Future Chemotherapy Cocktail?

Cited by 24 publications

References 198 publications

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

Synergistic effects of silybin and curcumin on virulence and carbapenemase genes expression in multidrug resistant Klebsiella oxytoca

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