Is “gallbladder length-to-width ratio” useful in diagnosing biliary atresia?

Choochuen, Panjai; Kritsaneepaiboon, Supika; Charoonratana, Vorawan; Sangkhathat, Surasak

doi:10.1016/j.jpedsurg.2019.01.008

Cited by 8 publications

(13 citation statements)

References 36 publications

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“…Regarding the differential diagnosis of CBA and CC, few scholars studied the sonographic features of fetal GB. Our study found that the GB ultrasound findings are more valuable in the prenatal diagnosis of CBA, consistent with the ultrasound characteristics of infant BA 16,17 . Zhou et al 16 identified a GB classification scheme, which showed a good diagnostic performance in infant BA diagnosis.…”

Section: A C C E P T E Dsupporting

confidence: 86%

“…Zhou et al [ 16 ] developed a GB classification scheme that showed a good diagnostic performance for BA diagnosis in infants. The GB length-to-width ratio was identified as a suggestive ultrasound parameter for infant BA screening [ 17 ]. Morel et al [ 14 ] reported one case of CBA with a crenelated and irregular GB wall associated with a biliary cyst on prenatal ultrasonography.…”

Section: Discussionmentioning

confidence: 99%

“…Zhou et al 16 identified a GB classification scheme, which showed a good diagnostic performance in infant BA diagnosis. The GB length-to-width ratio was a suggestive ultrasound parameter for infant BA screening 17 .…”

Section: A C C E P T E Dmentioning

confidence: 99%

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Differentiation of cystic biliary atresia and choledochal cysts using prenatal ultrasonography

Chen

Zeng

et al. 2022

Ultrasonography

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Purpose: To explore the performance of prenatal ultrasonography in the differential diagnosis of cystic biliary atresia (CBA) and choledochal cyst (CC).Methods: Fetuses diagnosed with hepatic hilar cyst in the 2 nd trimester were included in this study. A series of prenatal ultrasound examinations were performed in the 2 nd and 3 rd trimester. The diameter of the gall bladder (GB) and hepatic cyst were measured, as well as the wall thickness of the GB. The GB-cyst connection, visibility of the right hepatic artery (RHA), and other concomitant abnormalities were carefully evaluated.Neonatal transabdominal ultrasound examination was performed within 1 week after birth, and clinical data were followed up to 6 months after birth.

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Section: A C C E P T E Dsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Differentiation of cystic biliary atresia and choledochal cysts using prenatal ultrasonography

Chen

Zeng

et al. 2022

Ultrasonography

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“…Compared with the shape of gallbladder morphology, measuring gallbladder size was more objective in diagnosing of BA. Studies have reported that the gallbladder length-to-width ratio (LTWR) has a high sensitivity for BA diagnosis, but its speci city was relatively low [13,14]. It was known that the gallbladder length and width were different in children of different ages, but it was not clear whether there was a difference in gallbladder LTWR.…”

Section: Introductionmentioning

confidence: 99%

Analysis value of gallbladder length-to-width ratio for diagnosis of biliary atresia at different ages

Zhang

Tang

Zheng

et al. 2022

Preprint

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Objective To investigate the value of gallbladder length-to-width ratio(LTWR) by ultrasound for differentiating biliary atresia (BA) from other causes of hepatic cholestasis at different ages. Methods From January 2016 to June 2022, the data of 114 patients with BA and 69 patients with non-BA who underwent abdominal ultrasound and surgical exploration in the Affiliated Hospital of Zunyi Medical University were analyzed retrospectively.The demographic data, liver function, histopathology results, maximum length and maximum width of gallbladder and gallbladder LTWR measured by ultrasound were recorded. Results There were statistically significant differences between BA group and non-BA group in maximum length and width of gallbladder and gallbladder LTWR (P < 0.001). In all age groups (I: ≤30 days; II: 31–60 days; III: 61–90 days; IV: 91–120 days; V: ≥121 days), in which group III (61–90 days) had the highest area under the curve (AUC) of 0.831, and group V (≥ 121 days) had the lowest AUC of 0.548. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of gallbladder LTWR with a cut-off at 3.60 for BA in group III (61–90 days) were 84.4%, 69.2%, 87.1% ,64.3% and 80.0%, respectively. Conclusion Ultrasonography LTWR of gallbladder has certain value in the diagnosis of BA patients of all ages. The possibility of BA should be considered if the gallbladder LTWR > 3.16 as measured by ultrasound in infants with direct bilirubin increase.If the gallbladder LTWR > 3.60 at 61–90 days infants, early surgical exploration should be recommended. Level of evidence:Level IV

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“…Встречаются публикации о прижизненной анатомии желчного пузыря среди детей и подростков, однако они выполнены либо в условиях патологии [5][6][7][8]12], либо с целью определения эффективности различных способов оперативных вмешательств на органах гепатобилиарной системы [15,17].…”

Section: Introductionunclassified

Morphometric Parameters of the Gallbladder in Children and Adolescents according to Intravital Imaging Findings

Chemezov

Лозинский

Urbanskii

2021

Žurnal anatomii i gistopatologii

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The aimof the study is to establish age and gender patterns of morphometric parameters of the gallbladder in children and adolescents based on the findings of intravital imaging.Material and methods.The authors analyzed computed tomograms of the abdominal cavity of 75 children having no visible pathologies of the abdominal organs. The participants were divided into 4 agegroups: early childhood, first childhood, second childhood, adolescence. The diagnostic procedure was performed on 16-slice computed tomographs; a longitudinal size, a distance between the right and left walls, a distance between the anterior and posterior walls and a volume of the gallbladder were detected in the study. The data obtained were processed using variational and statistical methods,the mean value (M), standard error (m) and the significance of differences according to the Student's t-test were determined.Results.The longitudinal size of the gallbladder averaged 4.5±0.1 cm in the entire sample, 4.3±0.1 cm in girls, and 4.6±0.1 cm in boys; there was detected an increase from 3.7±0.2 cm in group 1 to 4.8±0.3 cm in group 4 (p=0.023). The transverse size of the gallbladder was 1.8 ± 0.1 cm, while in girls -1.8 ± 0.1 cm, and in boys - 1.7 ± 0.1 cm. The value of this parameter increased in all examined children from 1.3 ± 0.1 cm in group 1 to 2.1 ± 0.1 cm in group 4 (p = 0.001). In patients of all groups the average value of the distance between the anterior and posterior walls of the gallbladder was 2.8±0.1 cm. In girls this parameter was 2.8±0.1 cm, and in boys -2.9±0.1 cm. This parameter increased in all patients from 2.4±0.1 cm in group 1 to 3.4±0.1 cm in group 4 (p=0.001). The volume of the gallbladder constituted 13.6±0.8 cm3, in girls this parameter was 12.8±1.0 cm3, and in boys - 14.2±1.3 cm3. The volume of the gallbladder increased in all patients from 7.3±1.1 cm3 in group 1 to 19.4±1.9 cm 3 in group 4 (p=0.001).Conclusion.The most significant increase in most studied parameters (p≤0.05) was noted in children of the first childhood group compared with children of the early childhood group, and in adolescents co mpared with children from the second childhood group without differentiation by gender. A significant increase in the morphometric parameters of the gallbladder was determined mainly in boys of the first childhood group compared with children of the early childhood group and in adolescents compared with children of the second childhood group. In girls there was observed a tendency to a smooth increase in parameters from group to group; a significant increase was determined by the parameter “the distance between the anterior and posterior walls” in children of the second age group compared with children of the first age group (p=0.022). Most of the gallbladder morphometric parameters did not significantly differentiate in girls and boys of the same age group.

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Is “gallbladder length-to-width ratio” useful in diagnosing biliary atresia?

Cited by 8 publications

References 36 publications

Differentiation of cystic biliary atresia and choledochal cysts using prenatal ultrasonography

Differentiation of cystic biliary atresia and choledochal cysts using prenatal ultrasonography

Analysis value of gallbladder length-to-width ratio for diagnosis of biliary atresia at different ages

Morphometric Parameters of the Gallbladder in Children and Adolescents according to Intravital Imaging Findings

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