Is gastric carcinoma different between Japan and the United States?

Noguchi, Yoshikazu; Yoshikawa, Takaki; Tsuburaya, Akira; Motohashi, Hisahiko; Karpeh, Martin S.; Brennan, Murray F.

doi:10.1002/1097-0142(20001201)89:11<2237::aid-cncr12>3.0.co;2-9

Cited by 177 publications

(121 citation statements)

References 28 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…[19][20][21]29 It is interesting to note that in gastric cancer patients, very low positivity rates of H. pylori infection have been reported from the US, [30][31][32][33] and clinical studies demonstrated clearly lower survival rates when compared with Japanese patients at the same stages of disease. 34 Differences in prognosis between Eastern and Western series have been explained on the basis of different surgical approaches, less advanced stage of disease, and more careful tumor staging 35 ; the association with H. pylori status may shed more light on geographic variability in the prognosis of patients with gastric cancer. These speculations should be investigated in multicenter prospective studies.…”

Section: Discussionmentioning

confidence: 99%

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Marrelli

Pedrazzani

Berardi

et al. 2009

Cancer

119

View full text Add to dashboard Cite

NELL‐1 (Nel‐like molecule‐1) is a secreted osteogenic growth factor first identified in human craniosynostosis (CS) patients. NELL‐1 protein has been observed to promote bone and cartilage differentiation and to suppress adipogenesis in both in vitro and in vivo models. Despite these findings, the cell surface receptors of NELL‐1 have remained unknown. In this study, we observed for the first time that NELL‐1 promotes cell adherence in multiple cell lines, including ST2, C3H10T1/2, M2‐10B4, ATDC5, and MC3T3 cells. Additionally, we found that NELL‐1 binds to extracellular Integrinβ1 and induces cell focal adhesion. By utilizing siRNA methods, we determined that NELL‐1 cell surface binding and enhanced cell attachment were dependent on Integrinβ1 expression. Finally, we observed that pre‐coating of culture dishes or PLGA (polylactic‐co‐glycolic acid) scaffold with NELL‐1 resulted in a significant increase in both cell attachment and osteogenic differentiation. Our results identify for the first time a cell surface target of NELL‐1, Integrinβ1, and elucidate new functions of NELL‐1 in promoting cell adherence and osteogenic differentiation. J. Cell. Biochem. 113: 3620–3628, 2012. © 2012 Wiley Periodicals, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Marrelli

Pedrazzani

Berardi

et al. 2009

Cancer

119

View full text Add to dashboard Cite

show abstract

“…Previous cohort studies have highlighted the survival difference in patients with resectable GC between Western and Eastern countries [6][7][8][9][10][11][12][13][14]. Noguchi et al [6] reported a survival difference between high-volume centers in the USA and Japan that was no longer apparent after adjusting for tumor location.…”

Section: Introductionmentioning

confidence: 99%

“…Noguchi et al [6] reported a survival difference between high-volume centers in the USA and Japan that was no longer apparent after adjusting for tumor location. Verdecchia et al [7] demonstrated that the survival of Italian GC patients was inferior to that of Japanese GC patients and that this survival difference disappeared after adjusting for stage.…”

Section: Introductionmentioning

confidence: 99%

The survival difference between gastric cancer patients from the UK and Japan remains after weighted propensity score analysis considering all background factors

et al. 2015

Self Cite

View full text Add to dashboard Cite

Background Previous studies comparing survival between gastric cancer (GC) patients from the West and the East were based on the assumption that background factors and prognostic factors were identical. The aim of the current study was to compare the survival of GC patients from the UK and Japan using weighted propensity score analysis after identifying all different background factors. Methods Data from 464 patients from the Leeds Teaching Hospital NHS Trust, Leeds, UK (LTHT), and 465 patients from the Kanagawa Cancer Center Hospital, Yokohama, Japan (KCCH), who had surgery for GC were analyzed. Prognostic factors for overall survival (OS) and cancer-specific survival (CSS) were identified by univariate and multivariate analyses. Survival was compared by propensity score weighting after adjusting for all significantly different background factors. Results Most background factors were different between LTHT and KCCH patients. Unadjusted stage-specific OS and CSS were significantly better in KCCH. Independent prognostic factors for unadjusted OS and CSS were pT and pN in KCCH and in addition tumor location, pancreatectomy, resection margin status and number of examined lymph nodes in LTHT. Even after adjusting for all background characteristics, survival remained better in KCCH. Conclusions These results suggest that differences in background factors are unable to fully explain the survival difference of GC patients between UK and Japan. Comprehensive studies into the biology of GC and/or host factors are needed to fully understand the survival difference.

show abstract

“…Hypotheses have included more accurate pathologic staging, extended nodal dissection, and meticulous histopathologic evaluation of surgical specimens [21].…”

Section: Natural History Of Gastric Adenocarcinoma In the United Statmentioning

confidence: 99%

The role of laparoscopy for gastric surgery in the West

2009

View full text Add to dashboard Cite

Is gastric carcinoma different between Japan and the United States?

Cited by 177 publications

References 28 publications

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

The survival difference between gastric cancer patients from the UK and Japan remains after weighted propensity score analysis considering all background factors

The role of laparoscopy for gastric surgery in the West

Contact Info

Product

Resources

About