Is halofantrine ototoxic? Experimental study on guinea pig cochlea model

Iskander, Nagy M.; Youssef, T F; Ahmed, Mohamed; Mohamed, Abeer A.K.

doi:10.1017/s0022215110001301

Cited by 4 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Halofantrine has ototoxic [19] and fetal cardiotoxicity effects; however, in the rare situations in which halofantrine is the only therapeutic option available, it can still be given after carefully checking contraindications such as underlying cardiac diseases [20]. Halofantrine + SP and SP alone are not recommended in the new national anti-malaria dug policy [1,12].…”

Section: Discussionmentioning

confidence: 99%

Availability and prescription practice of anti-malaria drugs in the private health sector in Yemen

Ghouth

2013

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Availability and prescription practice of anti-malaria drugs in the private health sector in Yemen

Ghouth

2013

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Mefloquine also induced dose-dependent vestibular hair cell loss in the utricle in postnatal rat and the process has been attributed to activation of apoptosis by caspase-8 and caspase-9 (39). Halofantrine affected various cochlear structures, such as IHC, OHCs, SGNs and phalangeal cells in guinea pigs (40). QN also induced tinnitus in the behavioral model of tinnitus in rats (41); however, in another study animals treated with 200 mg/kg/d QN did not exhibit tinnitus-like behavior when assessed using the gap prepulse inhibition of acoustic startle (42).…”

Section: Mechanisms Of Ototoxicitymentioning

confidence: 98%

The Ototoxicity of Antimalarial Drugs—A State of the Art Review

Józefowicz-Korczyńska

Pajor

Grzelczyk

2021

Front. Neurol.

View full text Add to dashboard Cite

This review summarizes current knowledge about the occurrence of hearing and balance disorders after antimalarial drugs treatment. It also examines the clinical applications of antimalarials, their mechanisms behind this ototoxicity and how it can be monitored. It includes studies with larger numbers of patients and those in which auditory function was assessed using audiological tests. Some antimalarials have been repurposed for other conditions like autoimmune disorders, rheumatic diseases, some viral diseases and cancers. While old antimalarial drugs, such as quinoline derivatives, are known to demonstrate ototoxicity, a number of new synthetic antimalarial agents particularly artemisinin derivatives, demonstrate unknown ototoxicity. Adverse audiovestibular effects vary depending on the medication itself, its dose and route of administration, as well as the drug combination, treated disease and individual predispositions of the patient. Dizziness was commonly reported, while vestibular symptoms, hearing loss and tinnitus were observed much less frequently, and most of these symptoms were reversible. As early identification of ototoxic hearing loss is critical to introducing possible alternative treatments with less ototoxic medications, therefore monitoring systems of those drugs ototoxic side effects are much needed.

show abstract

“…Each group was maintained in a separate cage and was fed ad libitum for 24 h. Animals were housed under standardized conditions with free access to food and water under strict care and hygiene to maintain animals in normal healthy conditions. The rabbits were then sacrificed with an intraperitoneal injection of 100 mg of sodium pentobarbital followed by a 50-mg intracardiac injection after loss of consciousness if necessary [13]. The nasal mucosa was harvested, and the specimen from each animal was stained using hematoxylin and eosin (H&E).…”

Section: Methodsmentioning

confidence: 99%

Effect of formaldehyde inhalation on rabbit nasal mucosa: a light microscopic study—an animal model for inhalational irritants on nasal mucosa

Abdelkafy

Zittoon

Abou-Halawa

et al. 2021

Egypt J Otolaryngol

View full text Add to dashboard Cite

Background Formaldehyde is associated with many adverse health effects and is classified as a human carcinogen. Formaldehyde is highly water-soluble and readily absorbed and metabolized by the respiratory mucosa upon inhalation. The histopathological effects of formaldehyde on the nasal mucosa and olfactory nerves in adult New Zealand white rabbits were studied to validate this animal model of inhalational irritants. Results Compared to control group 1 (exposed to air), groups 2 and 3 (exposed to formaldehyde for 90 min and 210 min, respectively) exhibited disrupted nasal tissue, ulcerated epithelial coverings, markedly dilated blood vessels, and increased numbers of inflammatory cells in the lamina propria. The olfactory neuro-epithelium exhibited a reduction in the number of cilia. Many sustentacular cells lost their microvilli. Olfactory nerves exhibited nerve bundle shrinkage within the perineural sheath, leaving an empty space with evidence of edema within the nerve fibers. Conclusion Formaldehyde inhalation has destructive effects on the nasal mucosa and olfactory nerves in adult New Zealand white rabbits. These results validate the use of this animal model to assess the effects of inhalational irritants on the nasal mucosa.

show abstract

Is halofantrine ototoxic? Experimental study on guinea pig cochlea model

Abstract: Halofantrine has mild to moderate pathological effects on cochlea histology, and can be considered an ototoxic drug.

Cited by 4 publications

References 14 publications

Availability and prescription practice of anti-malaria drugs in the private health sector in Yemen

Availability and prescription practice of anti-malaria drugs in the private health sector in Yemen

The Ototoxicity of Antimalarial Drugs—A State of the Art Review

Effect of formaldehyde inhalation on rabbit nasal mucosa: a light microscopic study—an animal model for inhalational irritants on nasal mucosa

Contact Info

Product

Resources

About