Is Hydrogen Sulfide a Concern During Treatment of Lung Adenocarcinoma With Ammonium Tetrathiomolybdate?

Li, Xiang; Li, Na; Huang, Li; Xu, Shi; Zheng, Xue; Hamsath, Akil; Zhang, Mei; Dai, Lingyun; Zhang, Hui; Wong, Justin; Xian, Ming; Liu, Jinbao

doi:10.3389/fonc.2020.00234

Cited by 26 publications

(23 citation statements)

References 49 publications

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“…The latter, glutathione (see Figure 1 ) is used by cells to quench harmful free radicals and reduce oxidative stress. In addition, the former cysteine stabilizes complex structures of proteins, detoxifies heavy metals, participates in electron transfer reactions, and has other metabolic functions [ 95 , 96 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 ].…”

Section: Mini Reviews On the Roles Of Dmf Bupropion Same And VImentioning

confidence: 99%

“…Epigenetic reactions are reversible chromatin (gene and protein) alterations that occur in two forms, methylation and acetylations. With methylation, gene and chromatin structures are not available for transcription by replication enzymes; however, with acetylation of lysine or arginine residues in chromatin (histones), gene sequences are available to replication enzymes and transcription may occur [ 100 , 101 , 102 , 103 , 104 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 ]. To help understand and these reactions, as well as epigenetic protocols, the reader is advised to consult the text edited by Tollefsbol [ 111 ].…”

Section: Mini Reviews On the Roles Of Dmf Bupropion Same And VImentioning

confidence: 99%

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Proposed Neuroimmune Roles of Dimethyl Fumarate, Bupropion, S-Adenosylmethionine, and Vitamin D3 in Affording a Chronically Ill Patient Sustained Relief from Inflammation and Major Depression

Sachinvala¹,

Teramoto

Stergiou

2020

Brain Sciences

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We had discussed earlier that, after most of the primary author’s multiple sclerosis (MS) symptoms were lessened by prior neuroimmune therapies, use of dimethyl fumarate (DMF) gradually subdued his asthma and urticaria symptoms, as well as his MS-related intercostal cramping; and bupropion supplemented with S-adenosylmethionine (SAMe) and vitamin D3 (vit-D3) helped remit major depression (MD). Furthermore, the same cocktail (bupropion plus supplements), along with previously discussed routines (yoga, meditation, physical exercises, and timely use of medications for other illnesses), continued to subdue MD during new difficulties with craniopharyngioma, which caused bitemporal vision loss; sphenoid sinus infections, which caused cranial nerve-VI (CN6) palsy and diplopia; and through their treatments. Impressed by the benefit the four compounds provided, in this manuscript, we focus on explaining current neuroimmune literature proposals on how: (1) DMF impedes inflammation, oxidative stress, and cell death in CNS and peripheral tissues; (2) Bupropion curbs anxiety, MD, and enhances alertness, libido, and moods; (3) SAMe silences oxidative stress and depression by multiple mechanisms; and (4) Vit-D3 helps brain development and functioning and subdues inflammation. we realize that herein we have reviewed proposed mechanisms of remedies we discovered by literature searches and physician assisted auto-experimentation; and our methods might not work with other patients. We present our experiences so readers are heartened to reflect upon their own observations in peer-reviewed forums and make available a wide body of information for the chronically ill and their physicians to benefit from.

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Section: Mini Reviews On the Roles Of Dmf Bupropion Same And VImentioning

confidence: 99%

Section: Mini Reviews On the Roles Of Dmf Bupropion Same And VImentioning

confidence: 99%

Proposed Neuroimmune Roles of Dimethyl Fumarate, Bupropion, S-Adenosylmethionine, and Vitamin D3 in Affording a Chronically Ill Patient Sustained Relief from Inflammation and Major Depression

Sachinvala¹,

Teramoto

Stergiou

2020

Brain Sciences

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“…Through searching in miRDB, we observed that 7 target genes of miR-1285-3p which score >95: AHI1, DAB2IP, BTRC, YTHDF1, TMEM41B, SIKE1, and FMO5. After reviewing the literature, we disclosed that only YTHDF1 was bound up with lung adenocarcinoma [26][27][28]. As such, we surmised that LINC00337 functioned via in uencing YTHDF1 expression in lung adenocarcinoma.…”

Section: Linc00337 Regulates the Mir-1285-3p Target Gene Ythdf1mentioning

confidence: 96%

LncRNA LINC00337 Sponges miR-1285-3p to Promote Proliferation and Metastasis of Lung Adenocarcinoma Cells Through Up-Regulating YTHDF1

Zhang

et al. 2020

Preprint

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Background: Emerging studies have attested that long noncoding RNAs (lncRNAs) predominantly functioned in carcinogenesis of multiple developing human tumors. The current research aimed at probing the underlying participation and mechanisms of LINC00337 in lung adenocarcinoma.Methods: Here we analyzed TCGA and GTEx datasets and chose LINC00337 as research object. Cell proliferation, cell apoptosis, cell cycle, and invasion were detected in gain and loss experiment of LINC00337 both in vitro and in vivo. Moreover, RNA pull-down, luciferase reporter assays, western blotting analysis, rescue experiment were performed to investigate underlying molecular mechanisms of LINC00337 function. Results: LINC00337 was remarkably increased in lung adenocarcinoma. Also, LINC00337 knock-down was unraveled to repress cell invasion and proliferation as well as cell cycle, and gear up apoptosis in lung adenocarcinoma in vitro and in vivo. With respect to mechanism, LINC00337 knock-down boosted miR-1285-3p to be expressed and then restrained YTHDF1 to be expressed post-transcriptionally. Crucially, both miR-1285-3p decrement and YTHDF1 overexpression successfully countered the influence on cell proliferation, invasion and apoptosis caused by LINC00337 shRNA.Conclusions: These results suggest that LINC00337 acted as an oncogenic lncRNA, targeting miR-1285-3p and regulating YTHDF1 expression, to promote the progression of lung adenocarcinoma.

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“…2B ). Similarly, YTHDF1 knockdown partly blocks the pre-mRNA processing factor 6 (PRPF6) expression and cell growth ( 34 ). YTHDF1 positively facilitates protein synthesis by interacting with the translation machinery ( 58 ).…”

Section: M 6 a Readers In Lung Cancermentioning

confidence: 99%

“…This difference may be due to the uncertainty in gene expression between the mRNA and protein levels. This unique expression contributes to ATTM-induced increase in m 6 A in A549 cells ( 34 ). METTL3 promotes the translation of important oncogenes like EGFR in lung cancer.…”

Section: M 6 a As A Potential Therapeutic Target In Lung Cancermentioning

confidence: 99%

Importance of N⁶‑methyladenosine RNA modification in lung cancer (Review)

Wang

Zhao

et al. 2021

Mol Clin Oncol

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Is Hydrogen Sulfide a Concern During Treatment of Lung Adenocarcinoma With Ammonium Tetrathiomolybdate?

Cited by 26 publications

References 49 publications

Proposed Neuroimmune Roles of Dimethyl Fumarate, Bupropion, S-Adenosylmethionine, and Vitamin D3 in Affording a Chronically Ill Patient Sustained Relief from Inflammation and Major Depression

Proposed Neuroimmune Roles of Dimethyl Fumarate, Bupropion, S-Adenosylmethionine, and Vitamin D3 in Affording a Chronically Ill Patient Sustained Relief from Inflammation and Major Depression

LncRNA LINC00337 Sponges miR-1285-3p to Promote Proliferation and Metastasis of Lung Adenocarcinoma Cells Through Up-Regulating YTHDF1

Importance of N⁶‑methyladenosine RNA modification in lung cancer (Review)

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Is Hydrogen Sulfide a Concern During Treatment of Lung Adenocarcinoma With Ammonium Tetrathiomolybdate?

Cited by 26 publications

References 49 publications

Proposed Neuroimmune Roles of Dimethyl Fumarate, Bupropion, S-Adenosylmethionine, and Vitamin D3 in Affording a Chronically Ill Patient Sustained Relief from Inflammation and Major Depression

Proposed Neuroimmune Roles of Dimethyl Fumarate, Bupropion, S-Adenosylmethionine, and Vitamin D3 in Affording a Chronically Ill Patient Sustained Relief from Inflammation and Major Depression

LncRNA LINC00337 Sponges miR-1285-3p to Promote Proliferation and Metastasis of Lung Adenocarcinoma Cells Through Up-Regulating YTHDF1

Importance of N6‑methyladenosine RNA modification in lung cancer (Review)

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Importance of N⁶‑methyladenosine RNA modification in lung cancer (Review)