Is Hypericum perforatum agonist or antagonist of TRPC6 in neurons?

Abstract

Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease. Areas of particular interest are four topics. They are; A-Ion Channels (Na +-K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)

An extract of Hypericum perforatum induces wound healing through inhibitions of Ca2+ mobilizations, mitochondrial oxidative stress and cell death in epithelial cells: Involvement of TRPM2 channels

“…Similar to current results, the protective role of HP in rat sciatic nerve injury through inhibition of TRPM2 channels was reported (Uslusoy et al, 2017). Recently, it was reported that cutaneous wound healing is accelerated by mechanical stress, and treatment with hyperforin enhanced the acceleration through the facilitation of TRPC6 Ca 2+ signaling in HaCaT human keratinocyte cells and neurons (Nazıroğlu, 2016;Takada et al, 2017). More recently, the involvement of 2-APB through inhibition of TRPV2 on hypertrophic scar formation and wound healing in cell culture of rat keratinocytes was also reported (Ishii et al, 2018).…”

“…The 'St. John's wort' Hypericum perforatum is a wellknown traditional plant, and it has been used in the treatment of several diseases such as depression, inflammatory, and skin diseases (Meinke et al, 2012;Nazıroğlu, 2016). The main components of H. perforatum are hyperforin, flavonoids, hypericin, and their anti-apoptosis and antioxidant properties through inhibition of TRPM2 channel were reported in neuropathic pain, neutrophil activation and mechanical brain injury (Nazıroğlu et al, 2014a(Nazıroğlu et al, , 2014b(Nazıroğlu et al, , 2014cUslusoy et al, 2017).…”