2021
DOI: 10.3390/ijms22052388
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Is Inflammation a Friend or Foe for Orthodontic Treatment?: Inflammation in Orthodontically Induced Inflammatory Root Resorption and Accelerating Tooth Movement

Abstract: The aim of this paper is to provide a review on the role of inflammation in orthodontically induced inflammatory root resorption (OIIRR) and accelerating orthodontic tooth movement (AOTM) in orthodontic treatment. Orthodontic tooth movement (OTM) is stimulated by remodeling of the periodontal ligament (PDL) and alveolar bone. These remodeling activities and tooth displacement are involved in the occurrence of an inflammatory process in the periodontium, in response to orthodontic forces. Inflammatory mediators… Show more

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Cited by 94 publications
(98 citation statements)
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“…The compressive forces associated with orthodontic procedures promote inflammatory processes that are modulated by periodontal ligament cells [ 43 , 45 ]. Therefore, we investigated whether culturing with fatty acids affects the response of HPdLF to six hours of mechanical compression, at which time the expression and secretion of several cytokines are already increased [ 58 ].…”
Section: Resultsmentioning
confidence: 99%
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“…The compressive forces associated with orthodontic procedures promote inflammatory processes that are modulated by periodontal ligament cells [ 43 , 45 ]. Therefore, we investigated whether culturing with fatty acids affects the response of HPdLF to six hours of mechanical compression, at which time the expression and secretion of several cytokines are already increased [ 58 ].…”
Section: Resultsmentioning
confidence: 99%
“…The applied concentration of both fatty acids, PA and OA, has previously been used in other in vitro studies, and the used BSA concentration relates to serum albumin and is characteristic for obesity and hypertriglyceridemia [ 9 , 10 , 11 , 12 , 13 , 14 , 29 ]. The investigated cytokines play important roles in the defense against pathogens in periodontal diseases, as well as in the regulation of orthodontic force-induced alveolar bone remodeling [ 43 , 61 ]. Dysregulation by hyperlipidemic conditions could affect inflammation, which is important for both processes, and a basic investigation of the underlying biological changes of inflammatory markers would be relevant for further studies in obese patients with periodontal inflammation.…”
Section: Discussionmentioning
confidence: 99%
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