Is it necessary to use capsular endoscopy to diagnose celiac disease?

Парфенов, А И; Akopova, A O; Щербаков, П. Л.; Михеева, О М; Gudkova, R B; Scientific,

doi:10.26442/terarkh20189048-11

Cited by 5 publications

(3 citation statements)

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“…1d), and ulcers (Fig. 1e) 1–4 have only been reported by a few studies. Nomenclature referring to features of CD can vary among reviewers with limited SBCE experience resulting in under reporting of features 5 .…”

Section: Introductionmentioning

confidence: 93%

Assessment of disease severity on capsule endoscopy in patients with small bowel villous atrophy

Zammit

McAlindon

Sanders

et al. 2020

J of Gastro and Hepatol

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Background and Aim: There is a lack of uniformity of reporting on features of celiac disease (CD) on small bowel capsule endoscopy (SBCE). This makes determining extent of disease and comparison of severity of disease challenging. Methods: De-identified SBCEs of 300 patients (78 CD [26%], 18 serology negative villous atrophy [6%], and 204 controls with normal duodenal histology [68%]) were included. Videos were reviewed by two experts. All patients had duodenal histology taken within 2 weeks of SBCE. The degree of agreement in CD features and extent of disease was then determined. The resulting score for each factor was used to determine overall severity of disease.Results: There was substantial agreement in the kappa coefficient for the detection of CD features between reviewers (0.67). Agreement for extent of affected small bowel (SB) mucosa was high (0.97). On multiple regression analysis, several features of CD correlated with extent of affected SB mucosa for both reviewers. The odds ratios derived from this analysis were then used to score features of CD, enabling scores of severity to be calculated for each patient. The median overall scores for patients increased significantly according to the independent classification of severity by the capsule reviewers: mild (20, 0-79), moderate (45,, and severe (89, 65-130) (P = 0.0001). Conclusion:The good correlation of CD scores between expert reviewers confirms the validity of features of CD on SBCE. An objective score of CD features in the SB is useful in the follow up of patients with CD and serology negative villous atrophy.

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Section: Introductionmentioning

confidence: 93%

Assessment of disease severity on capsule endoscopy in patients with small bowel villous atrophy

Zammit

McAlindon

Sanders

et al. 2020

J of Gastro and Hepatol

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“…His findings were also supported by subsequent studies, which emphasized the importance of monitoring intestinal changes in patients with CD with the help of the video capsule. The main arguments were represented by the ease of automating the investigation and thereby eliminating the possibility of bias ( 53 , 54 ). In agreement with what was stated previously, in order to eliminate any diagnostic error, the initiation of a regular regimen, which includes gluten, is called for.…”

Section: Description Of Classic Celiac Diseasementioning

confidence: 99%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially in pediatrics, celiac disease (also called gluten enteropathy), is gaining more and more ground in terms of diagnosis, but also interest in research. The data from the literature of the last decades attest the chameleonic way of its presentation, there may be both classic onset symptoms and atypical symptoms. Given the impact played by celiac disease, especially in the optimal growth and development of children, the current narrative review aims to highlight the atypical presentation methods, intended to guide the clinician towards the inclusion of the pathology in the differential diagnosis scheme. To these we add the summary presentation of the general data and therapeutic lines regarding the underlying condition and the existing comorbidities. In order to place the related information up to date, we performed a literature review of the recent articles published in international databases. We bring forward the current theories and approaches regarding both classic celiac disease and its atypical manifestations. Among these we note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, but also disorders of biological constants and association with multiple autoimmunities. Knowing and correlating them with celiac disease is the key to optimal management of patients, thus reducing the subsequent burden of the disease.

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“…All patients underwent a morphological study of the TLS -verification of villous atrophy of more than Marsh stage 3A was assessed in favor of the diagnosis of celiac disease [16]. The analysis of anthropometric indicators was carried out using the WHO AnthroPlus and Med-Scape software(https://www.who.int/tools).…”

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confidence: 99%

Characteristics of iron deficiency in children with celiac disease

Ivenskaya,

Klimov,

Kuryaninova

et al. 2023

Medical news of the North Caucasus

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The iron deficiency (ID) structure was estimated in 235 children with celiac disease aged eight months to 18 years. The patients included in the study were divided into three groups: group I included 64 (27.2 %) children without ID, group II -106 (45.1 %) children with latent iron deficiency (LID), and group III -65 (27.7 %) with iron deficiency anemia (IDA). In the period of manifestation of celiac disease, ID conditions were diagnosed in 72.8 % of cases. At the same time, LID dominated the structure of ID forms in all age groups. It was found that in children with celiac disease complicated by IDA, there was a lag in the pace of physical development, as well as more pronounced gastrointestinal symptoms: vomiting was noted more often (p=0.022), bloating (p=0.027) and diarrhea (p=0.018), than in the group I. Total atrophy of the small intestine mucosa villus predominates in 87.7 % of patients with IDA. Thus, specialized laboratory and instrumental methods of diagnosing celiac disease in children should include a detailed analysis of ID.

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Is it necessary to use capsular endoscopy to diagnose celiac disease?

Cited by 5 publications

References 0 publications

Assessment of disease severity on capsule endoscopy in patients with small bowel villous atrophy

Assessment of disease severity on capsule endoscopy in patients with small bowel villous atrophy

Celiac disease - a pluripathological model in pediatric practice

Characteristics of iron deficiency in children with celiac disease

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