Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?

Abstract

A tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent cations such as calcium. We hypothesize that the formation of insoluble and rigid calcium oxalate augmented by glycine and valine counteracts strong acids such as HCl chemically, thus reducing cancer risks. The anticancer effects of the 2 amino acids can be explained from a chemical and biochemical perspective. A tumor-suppressive microenvironment could be established via the modification of the proteome without genome editing at the DNA level.

Aging and age-related diseases

“…[19][20][21][22][23] Yet, glycine and perhaps valine possess anticancer effects for their calcium binding property which counteracts mutagenic strong acids. 24 3 THE CLOCK SPRING OF AGING Generally, the replacement of glycine and valine by other amino acids in the above-mentioned longevity genes leads to longer lifespan, [25][26] due to the fact that the decrease of number of glycine and valine residues lowers the total affinity of the protein to calcium, consequently slowing down the formation of stressful calcium oxalate and perhaps other insoluble salts. The positively charged arginine residue can bind and transport anions such as oxalate as well as calcium 17,18 , and its substitutions prolonged life expectancy.…”

Neurological Sequelae of COVID-19: A Biochemical Perspective

“…As regards to personalized molecular biomarkers, acidic amino acids, for instance, counteract lysine in the formation of acids or insoluble salts in a convalescent patient with particular long-COVID factors rich in basic amino acid residues. , The extent in the competition among these amino acids may suggest that different intervention tactics are better suited to different individuals. The biochemical antagonism between strong acids and protein/salt aggregates accounts for the inverse association of cancer and Alzheimer’s disease. , Despite that all 20 amino acids are present in proteins, supplement of a particular amino acid enhances the synthesis of certain proteins overrepresented with this amino acid, thus impacting ion traffic and consequently influencing acid and calcium oxalate formation.…”

Mutagenesis by RNA-containing telomerase holoenzyme complex or R-loops: a missing piece of the puzzle

“…Calcium supplement has also displayed anti-neoplastic properties in numerous studies in that it is capable of neutralizing strong acids. 14,15 This scenario may account for the inverse association of neurodegenerative diseases and cancer as insoluble and stiff calcium oxalate was proposed to be present in patients with neurodegenerative disorders. 16 Potential link of R-loops to neoplasm R-loops are versatile structures associated with DNA replication stress and genome instability.…”