Is it possible to overcome antiapoptotic API2/MALT1 events in tumor B-cells by influencing Tregs in MALT lymphoma?

Dotlić, Snježana; Gašparov, Slavko; Lovric, Eva; Dominis, Mara; Korać, Petra

doi:10.1016/j.mehy.2012.07.001

Cited by 1 publication

(1 citation statement)

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“…The oncogenicity of B cells was observed through LIMA1-a cleavage and RNA deletion that can be mediated by API2-MALT1 (107). This suggests that LIMA1-a functions as a putative tumor suppressor in B cells akin to its inhibitory function in epithelial cells.…”

Section: Lima1 and Mucosa-associated Lymphoid Tissue Lymphomasmentioning

confidence: 99%

Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers

et al. 2023

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Actin is the most abundant and highly conserved cytoskeletal protein present in all eukaryotic cells. Remodeling of the actin cytoskeleton is controlled by a variety of actin-binding proteins that are extensively involved in biological processes such as cell motility and maintenance of cell shape. LIM domain and actin-binding protein 1 (LIMA1), as an important actin cytoskeletal regulator, was initially thought to be a tumor suppressor frequently downregulated in epithelial tumors. Importantly, the deficiency of LIMA1 may be responsible for dysregulated cytoskeletal dynamics, altered cell motility and disrupted cell-cell adhesion, which promote tumor proliferation, invasion and migration. As research progresses, the roles of LIMA1 extend from cytoskeletal dynamics and cell motility to cell division, gene regulation, apical extrusion, angiogenesis, cellular metabolism and lipid metabolism. However, the expression of LIMA1 in malignant tumors and its mechanism of action have not yet been elucidated, and many problems and challenges remain to be addressed. Therefore, this review systematically describes the structure and biological functions of LIMA1 and explores its expression and regulatory mechanism in malignant tumors, and further discusses its clinical value and therapeutic prospects.

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Section: Lima1 and Mucosa-associated Lymphoid Tissue Lymphomasmentioning

confidence: 99%