2012
DOI: 10.1186/2008-2231-20-61
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Is it right to look for anti-cancer drugs amongst compounds having antioxidant effect?

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Cited by 19 publications
(11 citation statements)
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“…Regarding the radiotherapy-induced oxidative stress which may lead to DNA damage and loss of acinar precursors of the salivary glands [3], reduced TAC in the CR group might be due to damage to the salivary glands [3], as well as delayed and time-dependent effect of cinnamaldehyde [20]. Although, it is not clear that the oxidative stress induced by ionizing radiation on malignant cells may be faded by the anti-oxidative effects of cinnamaldehyde or any other remedies which have been suggested to be protective for normal tissues [23]. …”
Section: Discussionmentioning
confidence: 99%
“…Regarding the radiotherapy-induced oxidative stress which may lead to DNA damage and loss of acinar precursors of the salivary glands [3], reduced TAC in the CR group might be due to damage to the salivary glands [3], as well as delayed and time-dependent effect of cinnamaldehyde [20]. Although, it is not clear that the oxidative stress induced by ionizing radiation on malignant cells may be faded by the anti-oxidative effects of cinnamaldehyde or any other remedies which have been suggested to be protective for normal tissues [23]. …”
Section: Discussionmentioning
confidence: 99%
“…To this end, conflicting findings were observed. Even though mechanism of antitumor activity of most of the plant based drugs has been established, still it is unclear with respect to mechanism of cancer cell death based on antioxidant property [35]. Many studies propose that there are additional functions accountable for the antitumor activity produced by these plant-based drugs that go beyond their antioxidant ability.…”
Section: Resultsmentioning
confidence: 99%
“…Antioxidants capture the superoxide radical, and thus, deplete the supply of hydrogen peroxide intracellular, which induces cancer. Moreover, it causes elimination of hydroxyl radicals, thus the use of antioxidants may reduce the effects of chemotherapy or radiation, due to the elimination of free radicals, since most of the radiation and antitumor drugs act precisely in the production of free radicals to struggle against cancer cells [31].…”
Section: Discussionmentioning
confidence: 99%