Is lead a concern in Canadian autistic children?

Clark, Brenda; Vandermeer, Ben; Simonetti, Antonio; Buka, Irena

doi:10.1093/pch/15.1.17

Cited by 32 publications

(21 citation statements)

References 23 publications

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“…Pica eating may be comorbid with a number of mental disorders, which are more likely to come to clinical attention than pica, the disorder, including intellectual development disorder, 18 autism spectrum disorder, 19 schizophrenia, 20 and obsessive-compulsive disorder. 21 In addition, pica eating can co-occur with hair pulling disorder and skin picking disorder when hair or skin…”

Section: Psychiatric Comorbiditymentioning

confidence: 99%

Pica and Rumination Disorder in DSM-5

Hartmann¹,

Becker²,

Hampton³

et al. 2012

Psychiatric Annals

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T he major proposed change for both pica and rumination disorder in the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition is their relocation from their current section, titled "Disorders Usually First Diagnosed in Infancy, Childhood, or Adolescence," 1 to the newly proposed section, "Feeding and Eating Disorders." 2 This change emphasizes that these disorders occur across the age range, including adulthood. Also, specifiers for severity and course have been suggested for each of these disorders, in keeping with DSM-5 format. Additional minor, but noteworthy, changes in phrasing that clarify ascertainment of diagnostic criteria are summarized in this paper. PICA Proposed Diagnostic Criteria for Pica The sine qua non of pica is the recurring ingestion of nonnutritive substances. 1 Changes to phrasing of diagnostic criteria in DSM-5 are intended to guide clinicians in distinguishing eating

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Section: Psychiatric Comorbiditymentioning

confidence: 99%

Pica and Rumination Disorder in DSM-5

Hartmann¹,

Becker²,

Hampton³

et al. 2012

Psychiatric Annals

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“…More recently, Clark (2010) showed that about 20 % of children with autism had BLLs of 2 μg/dL or greater, but none of the autistic children studied exceeded 10 μg/dL. Though the majority (65 %) of the group studied had pathological exploration of objects, the mild elevations of BLLs in these children suggested that the environment where they lived was relatively lead-free (Fig.…”

Section: Association With Autism Spectrum Disordersmentioning

confidence: 91%

“…Children with autism were showed to be at increased risk for Pb exposure and intoxication due to their exploratory oral behaviors and ingestion of dangerous amounts of Pb in environments that are usually safe (Clark 2010). In the past research performed in children affected by pica, it found that mean blood lead concentration was significantly higher in the autistic group than that in non-autistic psychotic children (Cohen et al 1976;Kinnell 1985).…”

Section: Association With Autism Spectrum Disordersmentioning

confidence: 99%

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Gorini

Muratori

Morales

2014

Rev J Autism Dev Disord

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An increasing evidence supports the role of industrial chemicals as contributors to the development of neurobehavioral disorders, including autism spectrum disorders, whose prevalence has progressively increased in recent years. Heavy metals, in particular, are recognized as neurodevelopmental toxins since they can be responsible of fetal damages which lead to neurological defects, developmental delays, learning disabilities and behavioral abnormalities. Most of the reviewed studies reported a relationship between exposure to metals during perinatal and early childhood periods and increased risk for autism. Moreover, the effects resulting from co-exposure to multiple metals should not be underestimated, especially in the assessment of children who live in developing countries or near heavily contaminated sites.

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“…Çaliçmamizda otizmli hastalarm ve saglikli çocukiarm kan kur §un düzeyleri arasmda da farkiilik saptanmamiçtir. Literatürde kur §un ve otizm arasmdaki iliçkiyi inceleyen çaliçmalarda da çeli §kili sonuçlar elde edilmekle beraber bir ili §kinin olmadigi yönünde saptamalar agirlik kazanmaktadir (27,28). Yorbik ve ark.…”

Section: Tarti §Maunclassified

The relation between blood lead and mercury levels and chronic neurological diseases in children

Dikme¹,

Arvas²,

Gür³

2013

Turk Pediatri Ars

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Amaç: Agir metal maruziyetinin çocukiukiarda kronik nörogeli §imsel ve nöropsikiyatrik hastaliklara yol açabildigi one sürülmektedir. Çali §manin amací kur §un ve civa maruziyetinin bazi çocukiuk çagi kronik nörogeli §imsel hastaliklan ile ili §kisini incelemektir Gereç ve Yöntem: istanbul Üniversitesi Cerrahpa §a Tip Fakültesi Çocuk Nörolojisi ve Çocuk Psikiyatrisi Poliklinikleri'nde ortak olarak izlenen motor-zeka geriligi, epilepsi, dikkat eksikiigi/hiperaktivite bozuklugu ve otizm tanili çocukiar hasta grubu (39 erkek, 20 kiz); ya § ve cinse göre e §le §tirilmi § ayni sayilarda saglikli çocukiar da kontrol grubu olarak çaliçmaya alindi. Çocukiardan aliñan venöz kan örneklerinde kur §un ve civa düzeyleri atomik absorpsiyon spektrofotometri yöntemi ile ölcüldü. Agir metal maruziyetine yol açabilecek bazi çevresel etmenlerin (a §ilanma durumu, baliktüketimi, annelerin di § dolgusu sayisi) olasi etkileri degerlendirildi. istatistiksel analizler için Mann Whitney U, Kruskal Wallis ve ki-kare testleri uygulandi. Bulgular: Olgu grubunun ya § ortalamasi 7,66, kontrol grubunun 7,68 yildi. Ortalama kan kur §un düzeyi hasta grubunda 1,91 pg/dL, kontrol grubunda 2,19 \Jig/dL, ortalama kan civa düzeyi hasta grubunda 0,84 pg/L, kontrol grubunda 0,99 pg/L saptandi. Hasta ve kontrol gruplarinda kan ve civa düzeyleri arasmda anlamli farklihk görülmedi. A §ilanma durumu, balik tüketim sikligi ve annelerin di § dolgusu sayisinin kan kurgun ve civa düzeyleri ile ili §kisi degerlendirildiginde olgu ve kontrol gruplari arasmda anlamli farklihk saptanmadi. Çikarimlar: Bu çali §ma kronik nörogeli §imsel hastaligi olan çocukiarda kan kurçun ve civa düzeylerinin, saglam çocukiardan tarkli olmadigmi göstermektedir. Ancak bu sonuç çevresel agir metal maruziyetinin insan sagligi üzerindeki önemini azaltmamaktadir (Turk Ped Ar § 2013; 48:221-5) Anahtar sözcükler: Çevresel maruziyet, kronik norogeliçimsel hastalik, kan kurçun düzeyi, kan civa düzeyi Summary Aim: The aim of our study was to investigate the relation between lead and mercury exposure and some chronic neurodevelopmental diseases in children. Material and Method:In the Departments of Pédiatrie Neurology and Pédiatrie Psychiatry clinics, children diagnosed with motor-mental retardation, epilepsy, attention deficit/hyperactivity disorder and autism were included in the study as the study group (39 boys and 20 girls). Age and sex matched healthy children were used as controls. Blood lead and mercury levels were measured using the atomic absorption spectrophotometry method. The possible effect of environmental factors that could cause exposure to heavy metals (such as vaccination, fish consumption and the number of dental fillings the mother had) were also considered. Results: The average age was 7.66 years and 7.68 years in the study and the control groups, respectively The average lead level in the blood was 1.91 \¡g/á\ in the study group, 2.19 |jg/dl in the control group. The average mercury level in the blood was 0.84 pg/L in the study group and 0.99 pg/L in the control gro...

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Is lead a concern in Canadian autistic children?

Cited by 32 publications

References 23 publications

Pica and Rumination Disorder in DSM-5

Pica and Rumination Disorder in DSM-5

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

The relation between blood lead and mercury levels and chronic neurological diseases in children

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