Is low magnesium a clue to arteriovenous fistula complications in hemodialysis?

Abstract

Hypomagnesemia is a significant pro-atherogenic factor and an important predictor of arteriovenous fistula complications.

Factors affecting the patency of arteriovenous fistulas for hemodialysis: Single center experience

“…Several studies have shown that a lack of magnesium causes vascular stenosis, platelet aggregation, inflammation, and oxidative stress, leading to dysfunction of the vascular endothelium and calcifications. The results of our earlier studies showed that magnesium may play an important role in the development or acceleration of atherosclerosis and, finally, in the development of vascular calcification in patients with complications of the AVF for HD . Rare investigations on circulating magnesium concentrations in dialysis patients found a clear association between low serum magnesium levels and the incidence of peripheral artery calcification .…”

“…However, the role of magnesium in this population is still insufficiently explained . Our recent research has found that the patients with complications of AVF has a significantly lower concentration of magnesium, which indicates the need for further research that could provide information about the actual impact of magnesium carbonate as a phosphate binder to prevent of thrombosis fistula. Results of this research are also indicate that magnesium is involved in the development of vascular calcification in patients with complications of the AVF, as the correlation and multiple regression analyses showed marked association between magnesium level and duration of the AVF.…”

“…We already know that current HD patients are older, more often have diabetes and/or cardiovascular comorbidity, and these are conditions that increase the risk of AVF dysfunction . Recently, we have shown that hypomagnesemia is a specific parameter that predominantly determines primary AVF failure …”

“…4,5 Recently, we have shown that hypomagnesemia is a specific parameter that predominantly determines primary AVF failure. 6 Moreover, prospective multicenter studies have established that, besides anatomical and biochemical parameters, the experience of the surgeon concerning the passability and functionality of AVF can be affected by certain practices of different medical centers. 2 Available research results indicate a large number of often contradictory parameters that might affect the functioning of AVF.…”

Association between serum magnesium and blood count: influence of type 2 diabetes and central obesity

“…Immature PLT fraction is elevated in patients with type 2 diabetes and associated with poor glycaemic control (37) . The Mg level was inversely correlated with leucocyte (P = 0⋅028) and PLT (P = 0⋅016) counts on patients with haemodialysis (38) . However, serum Mg was inversely associated with thrombocytopenia in healthy adults (39) .…”