Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study

Yang, Guang-zhi; Li, Jing; Jin, Hua; Ding, Haiyan

doi:10.1186/1746-1596-8-14

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…Mammary sarcomas are a heterogeneous group of malignant neoplasms that arise from the mammary stroma [2]. Angiosarcomas, one of the most common forms of mammary sarcoma, are developed from the endothelial lining of the blood vessels [3].…”

Section: Discussionmentioning

confidence: 99%

Primary angiosarcoma of the breast: a case report

et al. 2013

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Primary angiosarcoma of the breast is extremely rare. Radiologic findings are often non specific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor because of the high rates of local recurrence and early development of metastasis. Surgical removal followed by adjuvant chemotherapy seems improve the prognosis.We report a case of a 33- year-old woman with a highly vascular mass in her right breast which is suggestive of malignancy at radiology. Initial core needle biopsy showed a benign hemangioma. The patient underwent a mastectomy. The tumor histology showed papillary formations and vascular structures lined by atypical cells with hyperchromatic nucleus and eosinophilic cytoplasm with solid areas. The tumor cells expressed CD34 and CD31 but were negative for cytokeratin. The diagnosis of angiosarcoma grade III was made. The patient is now receiving chemotherapy. She is still alive.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1530481200889780

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Section: Discussionmentioning

confidence: 99%

Primary angiosarcoma of the breast: a case report

et al. 2013

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“…Primary sarcoma of the breast is a heterogeneous entity composed of malignant neoplasms arising from the mammary stroma 6. Radiation-induced secondary angiosarcoma of the breast is a more common entity, while de novo primary angiosarcoma is rare and accounts for less than 0.04% of all breast malignancies 7.…”

Section: Discussionmentioning

confidence: 99%

Primary angiosarcoma of the breast: a radiation oncologist’s perspective with a concise review of the literature

Singh

Chufal²,

Pahuja

et al. 2019

BMJ Case Rep

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A 28-year-old premenopausal woman presented with a painful rapidly growing mass in her right breast and was evaluated with a core needle biopsy, which was suggestive of poorly differentiated carcinoma. Immunohistochemical evaluation revealed primary angiosarcoma of breast. Whole body 18flouro-deoxyglucose positron emission tomography CT showed few metabolically active soft tissue lesions in upper inner quadrant of right breast. The patient underwent breast conservation surgery and in view of positive surgical margins, received adjuvant radiation therapy. Post-treatment completion, the patient has been disease free for 6 months. Primary angiosarcoma of the breast is a rare malignancy which is best managed with a surgery as first approach, with due importance being given to the patient’s perspective on their disease and choices for adjuvant treatment. Decisions in addition to adjuvant radiotherapy need to be made in the multidisciplinary clinic, due to paucity of data.

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“…S 100 and CD31 are negative, while desmin and CD34 are positive in some cases [18]. Langerhans cell sarcoma (LCS) or mammary sarcoma (MS) may be similar to PES but immunohistochemistry, in the LCS the tumour cells are positive for CD1a, S-100 protein and langerin strongly and diffusely [29], while in MS CD10 and vimentin are positive diffusely whereas epithelial markers and other myoepithelial or myogenic markers were all negative [30]. In Prostatic stromal sarcoma (PSS) unlike the PES, immunohistochemically, the tumour cells are widely positive for vimentin, CD56, CD99 and focally positive for synaptophysin, CD10, progesterone receptor, desmin and CD34, but negative for EMA, cytokeratin, estrogen receptor, S-100 and myoglobin [31].…”

Section: Discussionmentioning

confidence: 99%

Vulvar “proximal-type” epithelioid sarcoma: report of a case and review of the literature

Patrizi

Corrado²,

Saltari

et al. 2013

Diagn Pathol

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BackgroundThe “proximal-type” epithelioid sarcoma is a very rare kind of mesenchimal tumor characterized by the difficulty in histological diagnosis and the very aggressive biological behavior.CaseWe report of a case of a 63 years old woman with a vulvar “proximal-type” epithelioid sarcoma that underwent a radical surgical staging followed by an adjuvant radiotherapy. She is on follow-up care for 14 months and there is no clinical evidence of disease.ConclusionEven if quite rare the proximal type epithelioid sarcoma should be regarded as a separate entity of particularly aggressive biologic behaviour. Its diagnosis attracts controversies and criticism related to the surgical approach and the choice of an adjuvant therapy.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1508554852942125

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Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study

Cited by 10 publications

References 24 publications

Primary angiosarcoma of the breast: a case report

Primary angiosarcoma of the breast: a case report

Primary angiosarcoma of the breast: a radiation oncologist’s perspective with a concise review of the literature

Vulvar “proximal-type” epithelioid sarcoma: report of a case and review of the literature

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