Is obstructive sleep apnea associated with increased arterial stiffness in patients with COPD?

Clímaco, Danielle Cristina Silva; Lustosa, Thais C.; Silva, Marcus Vinícius de França Pereira; Lins-Filho, Ozeas L; Rodrigues3, Valesca Kehrle; Neto, Luiz de Albuquerque P de Oliveira; Feitosa, Audes Diógenes de Magalhães; Cabral, Marília Montenegro; Pedrosa, Rodrigo Pinto

doi:10.1007/s11325-022-02635-w

Cited by 3 publications

(9 citation statements)

References 20 publications

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“…Figure 3 shows the frequency of OSA comorbidity in COPD patients in the included studies. In the included studies, there were a total of 27,064 participants, among whom there were 6515 patients with OS (the patient groups in Cliamaco's studies [22,23] and Economou's [56] and Papachatzakis's [55] studies overlapped, so the numbers of their participants were summed once). The number of studies with specific group size ranges covered by these studies is shown in Figure S1, whereas Figure S2 shows the number of OS patients in the included studies.…”

Section: Prevalence Of Overlap Syndromementioning

confidence: 99%

“…However, the above data indicate the need for awareness of the frequent co-occurrence of OSA in populations of COPD patients. [20][21][22][23][24]29,30,[34][35][36][37][38][39]41,43,45,50,53,54].…”

Section: Figurementioning

confidence: 99%

“…As expected, most studies showed that OS patients had a lower percentage of total sleep time (TST) and sleep time in the REM phase and non-rapid eye movement (NREM) stage 3, but higher sleep time in NREM stage 1 and a higher arousal index compared to the COPD-only group. Moreover, most commonly, in PSG examinations, investigators observed higher AHI, hypopnea index, and oxygen desaturation index (ODI), but lower nadir and mean oxygen saturation (SaO 2 ), when COPD was associated with OSA [21][22][23][24][34][35][36][37]39,41,43,45,46,51,54].…”

Section: Polysomnography Findings and Pulmonary Function In Overlap S...mentioning

confidence: 99%

“…The most important pathophysiological triggers for CVD observed in OS were intermittent hypoxia, recurrent arousals, and intrathoracic pressure swings [108]. The OS patients showed significantly higher irregularity of overnight pulse and greater common carotid artery stiffness than COPD-only or OSA-only patients, which could lead to cor pulmonale [20,23,26,51,[109][110][111][112].…”

Section: Hypertension Coronary Heart Disease and Cardiovascular Disea...mentioning

confidence: 99%

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The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review

et al. 2022

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Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are common diseases that strongly impact the quality and length of life. Their coexistence is determined by overlap syndrome (OS). This systematic review aims to define the significance of these comorbidities according to the current state of knowledge. For this systematic review, we searched PubMed, Scopus, and Cochrane for studies published between 2018 and 26 October 2022, to find original, observational, human studies published in English, where the diagnosis of COPD was according to the Global Initiative for Obstructive Lung Disease guidelines and the diagnosis of OSA was based on polysomnography. The quality of studies was assessed using the Newcastle–Ottawa quality assessment tool for cohort and case–control studies, as well as its modification for cross-sectional studies. Of the 1548 records identified, 38 were eligible and included in this systematic review. The included studies covered a total population of 27,064 participants. This paper summarizes the most important, up-to-date information regarding OS, including the prevalence, meaning of age/gender/body mass index, polysomnography findings, pulmonary function, comorbidities, predicting OSA among COPD patients, and treatment of this syndrome.

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Section: Prevalence Of Overlap Syndromementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Polysomnography Findings and Pulmonary Function In Overlap S...mentioning

confidence: 99%

Section: Hypertension Coronary Heart Disease and Cardiovascular Disea...mentioning

confidence: 99%

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The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review

et al. 2022

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“…9 PWV is also a measure of arterial stiffness. PWV and IMT in the carotid artery are associated with a range of chronic conditions and health behaviors, such as metabolic syndrome, hypertension, diabetes, hyperlipidemia, chronic obstructive pulmonary disease, 10 and smoking. PWV and IMT have a significantly higher prevalence in patients with severe OSA than in patients with mild to moderate OSA or healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Long-term outcomes regarding arterial stiffness and carotid artery atherosclerosis in female patients with rapid eye movement obstructive sleep apnea

et al. 2022

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Objective Rapid eye movement (REM) obstructive sleep apnea (OSA) is associated with the risk of cardiovascular events. Arterial stiffness and carotid artery intima-media thickness (IMT) predict these events, but few relevant studies have been conducted. We compared long-term changes in arterial stiffness and IMT between patients with REM OSA and non-REM (NREM) OSA receiving continuous positive airway pressure (CPAP) or oral appliance (OA) therapy. Methods Newly diagnosed female patients with OSA received CPAP (n = 6) or OA (n = 7). Pulse wave velocity (PWV) and carotid artery ultrasound were performed before and 60 months after treatment. Results There were no differences in baseline characteristics (mean age: 56.0 vs. 61.3 years; mean body mass index: 22.6 vs. 21.7 kg/m2) between the REM OSA and non-REM OSA groups. The median apnea-hypopnea index was lower in the REM OSA group than in the non-REM OSA group. Increased PWV (12.92 ± 1.64 to 14.56 ± 2.73 m/s) and deteriorated glucose metabolism were observed in the REM OSA group after treatment. PWV, IMT, and cardiovascular risk factors were unaffected in the non-REM OSA group. Conclusion Arterial stiffness and glucose metabolism are deteriorated in patients with REM OSA compared with these parameters in patients with non-REM OSA after CPAP or OA treatment.

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Correlational Research Progress in Patients with COPD-OSAHS Overlap Syndrome

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2023

ACM

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Is obstructive sleep apnea associated with increased arterial stiffness in patients with COPD?

Cited by 3 publications

References 20 publications

The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review

The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review

Long-term outcomes regarding arterial stiffness and carotid artery atherosclerosis in female patients with rapid eye movement obstructive sleep apnea

Correlational Research Progress in Patients with COPD-OSAHS Overlap Syndrome

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