Is ovarian hyperstimulation associated with higher blood pressure in 4-year-old IVF offspring? Part I: multivariable regression analysis

Seggers, Jorien; Haadsma, Maaike L.; Gemert, Sacha la Bastide‐van; Heineman, Maas Jan; Middelburg, Jack J.; Roseboom, Tessa J.; Schendelaar, Pamela; Heuvel, Edwin R. van den; Hadders‐Algra, Mijna

doi:10.1093/humrep/det396

Cited by 40 publications

(30 citation statements)

References 31 publications

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“…Effects observed in IVP produced adult mice born include increased blood pressure associated with increased enzymatic activities of angiotensin‐converting enzyme in the serum and hepatic phosphoenolpyruvate carboxykinase in the liver in female offspring at 27 weeks (Watkins et al, ). Interestingly, similar observations were made in humans where ovarian hyperstimulation has been associated with higher blood pressure in 4 year old IVF children (Seggers et al, ). Altered liver phospholipid profiles linked to atherosclerosis and diabetes were also observed in CD1 adult mice born after IVP using KSOM AA (Li, Xiao, et al, ).…”

Section: Long‐term Effects Of Artsupporting

confidence: 68%

Long term effects of ART: What do animals tell us?

Duranthon

Chavatte‐Palmer

2018

Molecular Reproduction Devel

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Early stages of mammalian embryonic development are now known to be very sensitive to their microenvironment, with long term effects on fetal, postnatal, and adult health, thus extending to these early stages the concept of Developmental Origin of Health and Disease (DoHaD). In this scientific context, and with 3% of births in developed countries, safety of Assisted Reproductive Techniques procedures becomes a matter of concern. Besides, embryo technologies in domestic mammals, using huge number of embryos, do not seem to evidence heavy impacts on adult phenotypes. This paper first discusses what can or cannot be concluded from farm animal data, then develops long term effects of ART procedures (ovarian stimulation, in vitro fertilization and embryo culture) evidenced in model species (mainly mouse model). Recent literature demonstrates both individual and cumulative effects of each ART procedure on fetal and postnatal phenotypes. In a second part, because they are sources for further perturbations, immediate effects of ART on early embryo phenotypes at the cellular and molecular levels are described in both farm animals and model species. Mechanistic hypotheses supporting these ART induced phenotypic alterations are subsequently considered. Finally, taking into account interspecies differences in the mechanisms likely to be involved, the relevance of results obtained in animal models for human ART are discussed.

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Section: Long‐term Effects Of Artsupporting

confidence: 68%

Long term effects of ART: What do animals tell us?

Duranthon

Chavatte‐Palmer

2018

Molecular Reproduction Devel

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“…Various studies have shown that children born after ART have poorer metabolic and vascular profiles than naturally conceived children, with elevated systolic and diastolic blood pressures, higher fasting glucose levels, increased central adiposity and vascular dysfunction with pulmonary hypertension . According to those authors, the changes mentioned seems to be independent of prematurity, birthweight and parental characteristics, suggesting that features related to ART could directly contribute to these adverse health effects …”

Section: Introductionmentioning

confidence: 99%

Postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies: a cohort study

Valenzuela-Alcaráz

Serafini

Bijnens

et al. 2018

BJOG

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“…Other researchers have demonstrated that there were higher risks of birth defects and imprinted diseases in ART offspring [9][10][11]. A recent report showed that COH could lead to higher systolic blood pressure percentiles in 4-year-old children born following in vitro fertilization and embryo transfer (IVF-ET) [12]. Therefore, it is possible that COH might result in long-term impairments to the offspring, but the underlying mechanisms are unknown.…”

Section: Introductionmentioning

confidence: 99%

Preliminary proteomic analysis on the alterations in follicular fluid proteins from women undergoing natural cycles or controlled ovarian hyperstimulation

Zhang

et al. 2015

J Assist Reprod Genet

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Purpose To study the differences in protein expression profiles of follicular fluid (FF) between controlled ovarian hyperstimulation (COH) and natural ovulatory cycles. Methods Twelve infertile women undergoing in vitro fertilization and embryo transfer (IVF-ET), with matched clinical information, were retrospectively recruited in the IVF center of our university hospital, including six undergoing COH and another six with natural cycles. FF was sampled from dominant follicles with mature oocytes. Protein expression profiles in each FF sample were analyzed respectively using twodimensional gel electrophoresis. Differentially expressed proteins were identified using matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF MS) and validated by western blotting. Differentially expressed proteins were further analyzed using Ingenuity Pathway Analysis (IPA) software.Results Two proteins were downregulated and 11 proteins were upregulated (change ≥1.5-fold, P<0.05) in the COH group. We identified one down-egulated and seven upregulated proteins using MALDI-TOF MS. Four differentially expressed proteins, including transferrin, complement component C3 (C3), haptoglobin and alpha-1-antitrypsin (AAT), were further validated by rate nephelometry and western blotting analyses. The IPA analysis revealed a significant network involved in the humoral immune and inflammatory responses. Conclusions The eight differentially expressed proteins were related to immune and inflammatory responses in the ovary. Our results provide new insights into the influence of COH on follicular (spp) development and IVF outcomes.

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Is ovarian hyperstimulation associated with higher blood pressure in 4-year-old IVF offspring? Part I: multivariable regression analysis

Cited by 40 publications

References 31 publications

Long term effects of ART: What do animals tell us?

Long term effects of ART: What do animals tell us?

Postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies: a cohort study

Preliminary proteomic analysis on the alterations in follicular fluid proteins from women undergoing natural cycles or controlled ovarian hyperstimulation

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