Is Pain Perception Altered in People With Depression? A Systematic Review and Meta-Analysis of Experimental Pain Research

Thompson, Trevor; Correll, Christoph U.; Gallop, Katy; Vancampfort, Davy; Stubbs, Brendon

doi:10.1016/j.jpain.2016.08.007

Cited by 130 publications

(99 citation statements)

References 69 publications

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“…In contrast, a recent meta-analysis found that depressed patients had higher experimental pain thresholds than controls, while pain tolerance was not different. 51 However, it is important to note that patients in our study generally showed low to moderate depressive symptoms and would not meet the criteria for a depressive disorder. Our study extends these findings and has addressed the contribution of depression to ethnic group differences in clinical pain and experimental pain sensitivity between Asian Americans and NHWs.…”

Section: Discussionmentioning

confidence: 66%

Depression and Pain in Asian and White Americans With Knee Osteoarthritis

Ahn

Weaver

Lyon

et al. 2017

The Journal of Pain

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Few studies have examined the underlying psychosocial mechanisms of pain in Asian Americans. Using the biopsychosocial model, we sought to determine whether variations in depression contribute to racial group differences in symptomatic knee osteoarthritis pain between Asian Americans and non-Hispanic whites. The sample consisted of 100 participants, including 50 Asian Americans (28 Korean Americans, 9 Chinese Americans, 7 Japanese Americans, 5 Filipino Americans, and 1 Indian American) and 50 age- and sex-matched non-Hispanic whites with symptomatic knee osteoarthritis pain. The Centers for Epidemiologic Studies Depression Scale was used to assess symptoms of depression, and the Western Ontario and McMaster Universities Osteoarthritis Index and the Graded Chronic Pain Scale were used to measure clinical pain. In addition, quantitative sensory testing was used to measure experimental sensitivity to heat- and mechanically-induced pain. The results indicated that higher levels of depression in Asian Americans may contribute to greater clinical pain and experimental pain sensitivity. These findings add to the growing literature regarding ethnic and racial differences in pain and its associated psychological conditions, and additional research is warranted to strengthen these findings. Perspective This article demonstrates the contribution of depression to clinical pain and experimental pain sensitivity in Asian Americans with knee osteoarthritis. Our results suggest that Asian Americans have higher levels of depressive symptoms and that depression plays a relevant role in greater clinical pain and experimental pain sensitivity in Asian Americans.

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Section: Discussionmentioning

confidence: 66%

Depression and Pain in Asian and White Americans With Knee Osteoarthritis

Ahn

Weaver

Lyon

et al. 2017

The Journal of Pain

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“…In a recent meta-analysis of experimental studies, Thompson et al97 concluded that potential effects of depression on pain perception are variable and likely to depend upon multiple factors, including the stimulus modality. This conclusion could help explain the discrepancies across clinical and experimental findings;97 however, further studies on the links between depression and pain perception area are needed in all age groups, including the elderly.…”

Section: Perception Of Pain and The Role Of Depressionmentioning

confidence: 99%

Depression and chronic pain in the elderly: links and management challenges

Zis

Daskalaki

Bountouni

et al. 2017

CIA

306

197

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Aging is an inevitable process and represents the accumulation of bodily alterations over time. Depression and chronic pain are highly prevalent in elderly populations. It is estimated that 13% of the elderly population will suffer simultaneously from the two conditions. Accumulating evidence suggests than neuroinflammation plays a critical role in the pathogenesis of both depression and chronic pain. Apart from the common pathophysiological mechanisms, however, the two entities have several clinical links. Their management is challenging for the pain physician; however, both pharmacologic and nonpharmacologic approaches are available and can be used when the two conditions are comorbid in the elderly patients.

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“…Extraction and coding of study data was performed by two authors (TT, KG), on a standardized form adapted from our previous studies [53,57] A number of decisions were made when computing effect sizes from extracted data. First, a few studies (k=3) provided data from multiple independent participant samples [3,48,61], e.g.…”

Section: Data Extractionmentioning

confidence: 99%

“…A random-effects model was chosen as heterogeneity was expected based on similar meta-analyses conducted for other disease conditions [53,57]. Several studies reported multiple ES data from the same samples and a few studies used different PD sample but with the same control group comparisons.…”

Section: Meta-analysismentioning

confidence: 99%