Is psoriasis a pre‐atherosclerotic disease? Increased insulin resistance and impaired endothelial function in patients with psoriasis

Abstract

This study demonstrated a significant impairment in endothelial function and increased insulin resistance in patients with psoriasis. This is a comprehensive study for identifying atherosclerotic risk factors in psoriasis. We suggest that psoriatic patients should be paid attention for atherosclerosis and its risk factors.

Patients with psoriasis are insulin resistant

“…[9][10][11][12][13][14][15] We aimed to investigate whether normal glucose-tolerant patients with moderate to severe, untreated psoriasis exhibit impaired insulin sensitivity compared with healthy, matched control subjects.…”

Metabolic Syndrome and Elevatedosteopontin: Their Associated Comorbidities in Patients With Psoriasis.

“…TNF-α may affect endothelium dysfunction by decreasing the levels of nitric oxide synthase and cyclooxygenase-1 [26].…”

Effect of treatment with methotrexate and coal tar on adipokine levels and indices of insulin resistance and sensitivity in patients with psoriasis vulgaris

“…Moreover, varied treatment regimens were used in many of the studies varying from topical agents, conventional systemic therapy and biological agents with different time points for evaluation. 12,17,[19][20][21][22][23] Many authors have reported that serum leptin, resistin, IL-6 are elevated in psoriatics in comparison to controls. 19,20,23 Some also have reported a positive correlation between disease severity and serum leptin and resistin levels and a negative correlation with serum adiponectin levels.…”