Is reverse cholesterol transport a misnomer for suggesting its role in the prevention of atheroma formation?

Quintão, Eder Carlos Rocha

doi:10.1016/0021-9150(95)05531-z

Cited by 30 publications

(14 citation statements)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The process of reverse cholesterol transport (RCT) involves HDL (in particular, a pre-beta migrating apoprotein apo A-1 HDL), transfer of free cholesterol from tissues to HDL, esteri®caton by LCAT, and either direct transfer to the liver or transfer to apoB-containing lipoproteins by cholesterol ester transfer protein (CETP) (Quintao, 1995). Higher CETP activity associated with lower concentrations of plasma HDL-C, has been noted in patients with angiographically detectable coronary artery disease (Hibino et al, 1996).…”

Section: Intravascular Lipoprotein Metabolismmentioning

confidence: 99%

Effect of synthetic triglycerides of myristic, palmitic, and stearic acid on serum lipoprotein metabolism

et al. 1999

View full text Add to dashboard Cite

Objectives: To determine relative effects of diets high in synthetic sources of myristic (14:0), palmitic (16:0) or stearic (18:0) acid on concentrations and metabolism of serum lipoproteins. Design: Eighteen healthy women participated in a three-way cross-over study for ®ve week periods separated by seven week washout periods, diets were assigned in random order. Subjects: Premenopausal women, not on medication, were from three races (Caucasian, African-American, Asian) and four apolipoprotein E phenotype groups (3a3, 3a2, 4a3, and 4a2). Intervention: During the ®rst week the subjects consumed a baseline diet providing 11 energy (en)% saturated fat, 10 en% polyunsaturated fat and 14 en% monounsaturated fat. Followed by test diets with 19 en% saturated fat (including 14 en% test saturated fatty acid), 3 en% polyunsaturated fat, and 14 en% monounsaturated fat for four weeks. Synthetic fats (trimyristin, tripalmitin, and tristearin) were used in blends with natural fats and oils. Results: Mean concentrations of serum total, esteri®ed and LDL cholesterol were signi®cantly lower after 18:0 than after 16:0 (n 16 ± 18, P`0.01 for treatment effect). Myristic acid (14:0) had an intermediate effect.Receptor-mediated degradation of 125 I-LDL in mononuclear cells obtained from the subjects was lower after 16:0 than after 14:0 and 18:0 (n 16 ± 18, P 0.05 for treatment effect). Differences in the digestibilities of the fats were not a major factor in the results. Strong cholesterolemic responses to the 16:0 diet were partly explained by apoE phenotype. Conclusions: As noted previously, stearic acid was neutral compared to 14:0 and 16:0. In contrast to studies involving natural fats, 14:0, fed as a synthetic triglyceride, was less cholesterolemic than 16:0 in a majority of subjects. ApoE phenotype in¯uenced the cholesterolemic response particularly when diets high in 16:0 were eaten.

show abstract

Section: Intravascular Lipoprotein Metabolismmentioning

confidence: 99%

Effect of synthetic triglycerides of myristic, palmitic, and stearic acid on serum lipoprotein metabolism

et al. 1999

View full text Add to dashboard Cite

show abstract

“…Most prospective epidemiologic studies have found an inverse correlation between plasma levels of high-density lipoprotein (HDL) and the incidence of atherosclerotic cardiovascular disease (1)(2)(3)(4). Although HDLlevels are known to be decreased by obesity, cigarette smoking, male sex, and diets high in polyunsaturated fat, the mechanismsof variation of HDL levels in populations are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Variability in Cholesteryl Ester Transfer Protein in Healthy Japanese Hyper-HDL-cholesterolemic Subjects.

et al. 2002

View full text Add to dashboard Cite

Objective Hyper-high density lipoprotein (HDL)-cholesterolemia has been considered to be anti-atherogenic and is referred to as longevity syndrome. However, hyper-HDLcholesterolemia induced by a cholesteryl ester transfer protein (CETP) deficiency may not be athero-protective, rather being atherogenic in nature. In a rural area in central Japan, the incidence of hyper-HDL-cholesterolemia has been found to be rather high (3.1 % of healthy people). We studied healthy Japanese people in this area with hyper-HDLcholesterolemia, particularly in relation to CETP. Methods Serum lipids were analyzed, and CETPmass was determined with an enzyme immunoassay method. Materials Blood was drawn after an overnight fast from 17 Japanese (5 males and 12 females) with serum HDLcholesterol (C) >100 mg/dl. Results Serum CETPmass in hyper-HDL-cholesterolemic subjects was distributed in a wide range. Serum CETP mass was positively correlated with low-density lipoprotein (LDL)-C, apolipoprotein (Apo) B, and LDL-C/HDL-C, with statistical significance. CETPwas also positively correlated with LDL-C/Apo B. Conclusion These results suggest that hyper-HDL-cholesterolemia may not be a single clinical entity, but a mixture of various pathophysiological conditions, and that the ratio of LDL-Cto HDL-Cand the size of LDL may be important factors in classifying these conditions. (Internal Medicine 41: 357-359, 2002)

show abstract

“…The role of cholesteryl ester transfer protein (CETP) in intravascular cholesteryl ester (CE) transport has been fully reviewed [2,[10][11][12]. In addition to promoting a bidirectional flux of cholesteryl ester between LP, CETP also mediates the heteromolecular exchange whereby triglyceride (TG)-rich LP gains CE and loses TG [13].…”

mentioning

confidence: 99%

“…The role of CETP in atherogenesis is controversial [2,10,11,16]. High levels of plasma CETP were reported in several dyslipidaemias that are clearly related to the development of premature atherosclerosis [17][18][19][20][21].…”

mentioning

confidence: 99%

Plasma lipoproteins from patients with poorly controlled diabetes mellitus and "in vitro" glycation of lipoproteins enhance the transfer rate of cholesteryl ester from HDL to apo-B-containing lipoproteins

et al. 1997

View full text Add to dashboard Cite

Several factors may be responsible for the high prevalence of premature atherosclerosis in diabetes mellitus [1], including possible alterations in the reverse cholesterol transport system [2][3][4][5][6][7].Plasma lipoproteins (LP) are continually modified intravascularly and in the interstitium due to enzymatic action and interchanges of lipid fractions and apolipoproteins [2,8,9]. The role of cholesteryl ester transfer protein (CETP) in intravascular cholesteryl ester (CE) transport has been fully reviewed [2,[10][11][12]. In addition to promoting a bidirectional flux of cholesteryl ester between LP, CETP also mediates the heteromolecular exchange whereby triglyceride (TG)-rich LP gains CE and loses TG [13]. The direction of this flow is partially determined by the lipid composition of the LP involved [14,15]. Diabetologia (1997Diabetologia ( ) 40: 1085Diabetologia ( -1093 Plasma lipoproteins from patients with poorly controlled diabetes mellitus and "in vitro" glycation of lipoproteins enhance the transfer rate of cholesteryl ester from HDL to apo-B-containing lipoproteins Summary Alterations in the reverse cholesterol transport system have been described in diabetic mellitus patients in several but not all studies. Furthermore, recently published investigations suggest that a faster "in vitro" transfer rate of cholesteryl ester from high density lipoproteins to apoB-containing lipoproteins could be solely ascribed to variation of the plasma lipoprotein composition and concentration in the diabetic state. The present study analysed the influence of lipoprotein glycation on the cholesteryl ester transfer protein-mediated transfer of esterified cholesterol from high density lipoprotein and its subfractions to lighter density lipoproteins. For this purpose two sets of "in vitro" experiments were carried out utilizing:1) plasma lipoproteins drawn from diabetic and from normal subjects and; 2) normal lipoproteins or partially purified cholesteryl ester transfer protein submitted to "in vitro" glycation. The transfer rate of 14 C-cholesteryl ester labelled HDL subfractions to low or very low density lipoproteins was measured in all experiments. After incubations with plasma d > 1.21 g/ml or with purified cholesteryl ester transfer protein, apoB-containing lipoproteins were precipitated with a dextran sulfate/MgCl 2 solution. The "in vitro" glycation of the partially purified cholesteryl ester transfer protein markedly impaired its activity. However, greater transfer rates were observed when lipoproteins from diabetic individuals or the "in vitro" glycated lipoproteins were utilized. This effect was attributed to glycation of the protein component of HDL. In conclusion, lipoprotein glycation elicits an enrichment of the apoB-containing lipoproteins with cholesteryl ester that is likely related to the premature atherosclerosis in patients with poorly controlled diabetes. [Diabetologia (1997[Diabetologia ( ) 40: 1085[Diabetologia ( -1093

show abstract

Is reverse cholesterol transport a misnomer for suggesting its role in the prevention of atheroma formation?

Cited by 30 publications

References 138 publications

Effect of synthetic triglycerides of myristic, palmitic, and stearic acid on serum lipoprotein metabolism

Effect of synthetic triglycerides of myristic, palmitic, and stearic acid on serum lipoprotein metabolism

Variability in Cholesteryl Ester Transfer Protein in Healthy Japanese Hyper-HDL-cholesterolemic Subjects.

Plasma lipoproteins from patients with poorly controlled diabetes mellitus and "in vitro" glycation of lipoproteins enhance the transfer rate of cholesteryl ester from HDL to apo-B-containing lipoproteins

Contact Info

Product

Resources

About