Sea level rise (SLR) is among the major climate change effects threating the coasts of the Mediterranean basin, which are increasingly exposed to coastal flooding, especially along the low lying coastal plains, river deltas, lagoons and reclamation areas. Coastal erosion, beach retreat and marine flooding are already causing unprecedented environmental and socio-economic impacts on coastal populations. According to the Intergovernmental Panel on Climate Change (IPCC) these effects are expected to worsen by 2100 and beyond with a projected global SLR up to about 1 m above the current level. This study provides an overview of the Mediterranean basin, focusing on the vulnerable city of Venice, which is particularly exposed to marine flooding due to SLR and land subsidence. We show the current and future sea level trend as well as a flooding scenarios in the absence of the Experimental Electromechanical Module (MoSE), which is protecting the city of Venice since 2020. To understand the awareness of citizens in Venice to address SLR, we have engaged a group of stakeholders through a structured participatory process to develop solution-oriented, case-specific and site-specific Policy Tools. Our results show that the Policy Tools contain relevant, effective and implementable actions stemming from stakeholder interaction and consensus building, identifying relevant issues that should be considered for SLR adaptation policies. A more extensive participation in public processes is required to materialize the Policy Tools into concrete actions to help vulnerable areas adapt to the expected SLR by the end of this century.