Is serum procalcitonin a reliable diagnostic marker in children with acute respiratory tract infections? A retrospective analysis

Schützle, Heike; Förster, Johannes; Superti‐Furga, Andrea; Berner, Reinhard

doi:10.1007/s00431-008-0899-3

Cited by 31 publications

(15 citation statements)

References 27 publications

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“…PCT synthesis is detectable in serum within 4 h, and peak levels occur at 12 to 48 h (3). In distinction to synthesis of C-reactive protein and the other acute-phase reactants, the existing data suggest that PCT levels rarely increase in response to pure viral infection (9,11,35,37,41). The lack of response to viral disease is postulated to result from viral stimulation of macrophages to synthesize alpha interferon, which, in turn, inhibits tumor necrosis factor (TNF) synthesis (14,15,18).…”

Section: Procalcitonin Biologymentioning

confidence: 99%

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Use of Plasma Procalcitonin Levels as an Adjunct to Clinical Microbiology

Gilbert

2010

J Clin Microbiol

139

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Procalcitonin (PCT) is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi, and some parasites. Current PCT assays are rapid, specific, and of sufficient sensitivity to detect increases in PCT serum levels within 4 to 6 h of initiation of infection. Clinically, PCT levels may help in decisions regarding the need for empirical antibiotic therapy, "source control" of infection, and duration of antibiotic therapy. The addition of PCT levels to bacterial culture and viral detection results can assist with the separation of colonization and invasion by pathogenic bacteria.

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Section: Procalcitonin Biologymentioning

confidence: 99%

“…In patients with clinical evidence of infection and repeatedly normal PCT levels, it is highly unlikely that the infection is due to pathogenic bacteria. In contrast, available data indicate that patients with influenza, severe acute respiratory syndrome (SARS), and other pure viral infections have low serum PCT levels (9,11,35,37,41).…”

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confidence: 99%

Use of Plasma Procalcitonin Levels as an Adjunct to Clinical Microbiology

Gilbert

2010

J Clin Microbiol

139

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“…Eine retrospektive Studie untersuchte 327 Kinder mit Atemwegserkrankungen und konnte zeigen, dass bei PCTWerten <0,1 ng/ml eine bakterielle Genese der Infektion unwahrscheinlich ist und auf eine Antibiotikatherapie verzichtet werden konnte [31]. Die Aussagekraft dieser Daten ist jedoch aufgrund des retrospektiven Charakters der Studie eingeschränkt.…”

Section: Pädiatrische Patientenunclassified

“…Bei Beurteilung des PCTWerts im Rahmen der Neugeborenensepsis müssen in den ersten beiden Lebenstagen die gesonderten Referenzbereiche beachtet werden [73]. Bisher wurde PCT nur an kleinen Studienpopulationen untersucht, die aufgrund ihres Studiendesigns nur sehr eingeschränkt beurteilbar sind (kleines Patientenkollektiv, Pilotstudie, Fall-Kontroll-Studie [31,32]). Die Ergebnisse belegen eine Reduktion der Antibiotikatherapietage und eine verkürzte Krankenhausliegedauer, die von der aktuell veröffentlichten prospektiven randomisierten Interventionsstudie von Stocker et al [33] bestätigt wurden.…”

Section: Steuerung Einer Antibiotikatherapieunclassified

Prokalzitoninbasierte Algorithmen

Hochreiter

Schroeder

2011

Anaesthesist

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Sepsis is one of the most cost-intensive conditions of critically ill patients in intensive care medicine. Furthermore, sepsis is known to be the leading cause of morbidity and of mortality in intensive care patients. Early initiation of antibiotic therapy can significantly reduce mortality. The development of resistance of bacterial species against antibiotics is a compelling issue to reconsider indications and administration of antibiotic treatment. Adequate indications and duration of therapy are particularly important for the use of highly potent substances in the intensive care setting. Until recently no laboratory marker has been available to distinguish bacterial infections from viral or non-infectious inflammatory responses. However, procalcitonin (PCT) appears to be the first among a large array of inflammatory markers that offers this possibility. Regular procalcitonin measurements can significantly shorten the length of antibiotic therapy, show positive influence on antibiotic costs and have no adverse affects on patient outcome.

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“…Schü tzle and colleagues retrospectively evaluated 327 children (mean age 22 mo) presenting with respiratory tract infections (8). PCR for 13 respiratory viruses and 4 atypical bacterial pathogens was performed.…”

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confidence: 99%

Discriminatory Value of Procalcitonin

Gilbert¹

2011

Am J Respir Crit Care Med

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Is serum procalcitonin a reliable diagnostic marker in children with acute respiratory tract infections? A retrospective analysis

Cited by 31 publications

References 27 publications

Use of Plasma Procalcitonin Levels as an Adjunct to Clinical Microbiology

Use of Plasma Procalcitonin Levels as an Adjunct to Clinical Microbiology

Prokalzitoninbasierte Algorithmen

Discriminatory Value of Procalcitonin

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