Is short-term antibiotic therapy safe in patients with central venous catheter-related Gram-negative bacteraemia?

Lee, Yu-Mi; Moon, Chisook; Park, Ki Ho

doi:10.1093/jac/dkaa435

Cited by 4 publications

(13 citation statements)

References 9 publications

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“…All cohort studies assessed the whole database of their institutions to identify patients fulfilling the inclusion criteria. Adult patients were included in four studies [ 24 , 26 , 27 , 29 ], whereas four studies included patients of all ages [ 22 , 23 , 25 , 28 ]. Catheter removal was mandatory for inclusion in five studies [ 22 – 24 , 27 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…Adult patients were included in four studies [ 24 , 26 , 27 , 29 ], whereas four studies included patients of all ages [ 22 , 23 , 25 , 28 ]. Catheter removal was mandatory for inclusion in five studies [ 22 – 24 , 27 , 29 ]. No study assessed antibiotic-associated adverse events.…”

Section: Resultsmentioning

confidence: 99%

“…of patients/total no. of patients Additional comment All-cause mortality Clinical cure Relapse Short-course Long-course Short-course Long-course Short-course Long-course Gram-negative bacteria Ruiz-Ruigòmez et al 2020 [ 22 ] 30-day mortality 3/23 (13%) 30-day mortality 1/29 (3%) 18/23 (78%) 23/29 (79%) 1/23 (4%) 0/29 (0%) Assessment of outcomes for 52 of 54 included patients Lee et al 2021 [ 24 ] 30-day mortality 4/30 (13%) 30-day mortality 6/29 (21%) 22/30 (73%) 18/29 (62%) 1/30 (3%) 1/29 (3%) Surapat et al . 2020 [ 29 ] 1/11 (9%) 4/33 (12%) Not performed Not performed 0/11 (0%) 1/33 (3%) We described only the phase 2 of the study Coagulase-negative staphylococci Hebeisen et al .…”

Section: Resultsmentioning

confidence: 99%

“…The risk of bias was assessed by the Newcastle-Ottawa scale [21] (Table 2). According to our study assessment seven studies [23][24][25][26][27][28][29] were of low methodological quality while one study [22] was of moderate quality.…”

Section: Study Characteristicsmentioning

confidence: 88%

“…The main characteristics of the included studies are presented in Table 1. Among eight included studies, seven were cohort studies [22][23][24][25][26][27][28]. One study described a retrospective cohort (i.e.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Short-Course Versus Long-Course Systemic Antibiotic Treatment for Uncomplicated Intravascular Catheter-Related Bloodstream Infections due to Gram-Negative Bacteria, Enterococci or Coagulase-Negative Staphylococci: A Systematic Review

et al. 2021

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Introduction:The optimal duration of systemic antimicrobial treatment for catheter-related bloodstream infections (CRBSI) is unknown. In this systematic review, we aimed to assess the efficacy of short-course treatment for CRBSI due to Gram-negative bacteria, coagulase-negative staphylococci and enterococci. Methods: We systematically searched the electronic bibliographic databases MEDLINE, EMBASE and Cochrane Library for studies published before February 2021. All studies that investigated the duration of adequate systemic antibiotic treatment in adult patients with uncomplicated intravascular catheter infections due to Gram-negative bacteria, coagulase-negative staphylococci or enterococci were eligible for inclusion. Studies including concomitant treatment with antibiotic lock therapy were excluded. The primary outcomes were clinical failure/cure, mortality and microbiologic-confirmed relapse. Results: Seven retrospective cohort studies and one case-cohort study met the inclusion criteria. No randomized controlled studies met inclusion criteria. The quality of the included studies was low (n = 7) to moderate (n = 1). No significant differences were observed regarding mortality and microbiological relapse between short-course and long-course systemic antibiotic treatment in patients with CRBSI due to coagulase-negative staphylococci or Gram-negative bacteria. No association was found between mortality and treatment duration in the two studies assessing enterococcal CRBSI. Conclusion:The limited data available suggests that shorter systemic antibiotic treatment

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 88%

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Short-Course Versus Long-Course Systemic Antibiotic Treatment for Uncomplicated Intravascular Catheter-Related Bloodstream Infections due to Gram-Negative Bacteria, Enterococci or Coagulase-Negative Staphylococci: A Systematic Review

et al. 2021

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Predictors of Acute Kidney Injury and 28-Day Mortality in Carbapenem-Resistant Acinetobacter baumannii Complex Bacteremia

Kim

Park

et al. 2021

Microbial Drug Resistance

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Duration of antibiotic therapy in central venous catheter-related bloodstream infection due to Gram-negative bacilli

Ruiz-Ruigómez

Aguado

2021

Current Opinion in Infectious Diseases

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Purpose of reviewThe aim of this study was to review recent data evaluating the duration of antibiotic therapy in central venous catheter-related bloodstream infection (CRBSI) due to Gram-negative bacilli (GNB).Recent findings CRBSI is the most common complication associated with the use of intravascular catheters. CRBSI directly contributes to increase additional days of hospitalization, morbidity and therefore economic costs. The incidence of GNB CRBSI has been increasing considerably in the last years; this has raised a concern due to the high reported rate of multi drug resistant bacteria in these infections what poses a considerable challenge for effective treatment. However, there are no specific guidelines for management of GNB-CRBSI and optimal treatment duration has not been clearly defined. Recent studies evaluating the impact of the duration of antibiotic therapy of GNB-CRBSI have shown that short-course antibiotic therapy might be as effective as long-course therapy once the central venous catheter (CVC) has been removed. SummaryCRBSI due to GNB has shown a rapid increase in the last years. Current guidelines recommend antibiotic treatment for at least 7-14 days, although no randomized clinical trials have evaluated the optimal duration of antibiotic therapy for GNB-CRBSI. Recent data suggest that administration of appropriate antibiotic therapy for 7 days or less may be as well tolerated and effective as longer courses in episodes of GNB-CRBSI, once the CVC has been removed.

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Is short-term antibiotic therapy safe in patients with central venous catheter-related Gram-negative bacteraemia?

Cited by 4 publications

References 9 publications

Short-Course Versus Long-Course Systemic Antibiotic Treatment for Uncomplicated Intravascular Catheter-Related Bloodstream Infections due to Gram-Negative Bacteria, Enterococci or Coagulase-Negative Staphylococci: A Systematic Review

Short-Course Versus Long-Course Systemic Antibiotic Treatment for Uncomplicated Intravascular Catheter-Related Bloodstream Infections due to Gram-Negative Bacteria, Enterococci or Coagulase-Negative Staphylococci: A Systematic Review

Predictors of Acute Kidney Injury and 28-Day Mortality in Carbapenem-Resistant Acinetobacter baumannii Complex Bacteremia

Duration of antibiotic therapy in central venous catheter-related bloodstream infection due to Gram-negative bacilli

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