Is sickle cell anemia a risk factor for severe dental malocclusion?

Costa, Cyrene Piazera Silva; Carvalho, Halinna Larissa Cruz Correa; Souza, Soraia de Fátima Carvalho; Thomaz, Érika Bárbara Abreu Fonseca

doi:10.1590/1807-3107bor-2015.vol29.0017

Cited by 20 publications

(20 citation statements)

References 12 publications

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“…As a result of the changes in the bone structure, malocclusion is believed to be more common in SCD. In fact, an association between SCA and moderate and very severe malocclusion in permanent dentition has been reported [53].…”

Section: Anemia and Oral Healthmentioning

confidence: 99%

Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

Boström

Lira-Júnior

2019

Curr Oral Health Rep

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Purpose of Review This review aims to summarize the literature on inherited hemoglobin and coagulation disorders, focusing on sickle cell disease (SCD), thalassemia, hemophilia, and von Willebrand disease (vWD), and their impact on oral health. Clinical dental management of patients with these conditions is also reviewed. Recent Findings There is no evident association between caries and SCD. Despite limited available studies, there may be a possible association between caries and thalassemia, which could relate to salivary changes in immunoglobulin A and Streptococcus mutans reported in these patients. Controversial results on the caries experience of hemophilia and vWD patients are found in the literature, which are likely to reflect differences in the provided preventive dental care of these patients rather than a biological association. Current evidence does not support any association between periodontal disease and SCD. The literature on periodontal disease and thalassemia shows controversial results although some evidence suggests differences in the gingival inflammation of thalassemia patients with increased levels of inflammatory cytokines and matrix metalloproteinases, deserving further investigation. The available literature does not provide evidence of an increased risk for gingival bleeding or periodontal disease in patients with hemophilia or vWD. Dental management of these patients requires appropriate measures to prevent infection and excessive bleeding. The use of local hemostatic may often be sufficient; however, in severe bleeding disorders, systemic hemostatic or replacement therapy may be required, and procedures are recommended to be planned with the patient's hematologist. Summary Maintaining good oral health through preventive dentistry is important for patients with inherited hemoglobin and coagulation disorders as that may prevent the risk of infection and the need for invasive dental treatments that can result in bleeding complications. Keywords Hematologic diseases. Anemia. Blood coagulation disorders. Oral health. Periodontal diseases. Dental caries This article is part of the Topical Collection on Systemic Diseases * Elisabeth A.

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Section: Anemia and Oral Healthmentioning

confidence: 99%

Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

Boström

Lira-Júnior

2019

Curr Oral Health Rep

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“…The highlights of these as they may pertain to older patients with SCD will be summarized in this review. Table 6 lists the dental comorbidities described in patients with SCD [106][107][108][109][110][111][112][113]. Caries are the most common dental comorbidity globally and in patients with SCD.…”

Section: Orofacial Comorbiditiesmentioning

confidence: 99%

Comorbidities in aging patients with sickle cell disease

Ballas

2018

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Sickle cell disease (SCD) in general and sickle cell anemia in particular is a highly complex disorder both at the molecular and clinical levels. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing multiple phenotypic expressions that constitute the various complications of the disease. Moreover, despite the fact that SCD is a chronic malady, its manifestations are both acute and chronic. The former include, among other things, the recurrent vaso-occlusive crises (its hallmark) and acute chest syndrome. The chronic complications include most commonly avascular necrosis and leg ulcers. Currently, survival of patients with SCD has improved dramatically thanks to newborn screening, antibiotic prophylaxis, better vaccine, safer blood transfusion and the use of hydroxyurea. It is the advent of these therapies that improved the survival. This improvement, however, introduced a third dimension of the disease: comorbidities that occur in aging people in the general population. There is concern that the gain in survival may be offset by the comorbidities. Thus it is the purpose of this review to identify the comorbidities in the elderly with SCD and differentiate them from the basis disease to implement proper therapies so that better survival could be maintained.

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“…The structural changes at the bone level, discussed above, promotes the development of dental malocclusion 14 (MO), abnormalities in the teeth, which causes a certain degree of aesthetic discomfort and functional disorders or disabilities. Craniofacial abnormalities are considered factors that contribute to the development of MO.…”

Section: Malocclusionmentioning

confidence: 99%

Odontostomatological manifestations in sickle cell disease: A systematic review

Nifosì¹,

Nifosì²,

Nifosí³

2017

Dent. Med. Probl.

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Sickle-cell disease is a frequent hemoglobinopathy which represents a major public health problem as a result of the continuous migration of populations. The clinical manifestations are chronic hemolytic anemia, vaso-occlusive crisis and infections; however, the involvement of the head and neck region remains poorly reported. Particularly, we do not know the prevalence of the odontostomatological manifestations.In this study, we reviewed the most recent literature on the topic. We have classified the alterations of the orofacial sphere into four categories: oral manifestations, bone changes, infections and various. We have described the main clinical manifestations of each one, along with their incidence and prevalence, trying to identify the pathophysiological mechanisms, correlations with vaso-occlusive crisis and possible therapeutic strategies. Several odontostomatological manifestations are described in patients with sickle cell disease. Some are typical, while others still need to be investigated, as for example the relationship between oral triggers and vaso-occlusive crisis.

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Is sickle cell anemia a risk factor for severe dental malocclusion?

Cited by 20 publications

References 12 publications

Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

Comorbidities in aging patients with sickle cell disease

Odontostomatological manifestations in sickle cell disease: A systematic review

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