Is single umbilical artery an independent risk factor for perinatal mortality?

Burshtein, Shimon; Levy, Amalia; Holcberg, Gershon; Zlotnik, Alexander; Sheiner, Eyal

doi:10.1007/s00404-009-1326-3

Cited by 48 publications

(59 citation statements)

References 12 publications

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“…The presence of an isolated SUA has also been associated with increased rates of perinatal mortality [15]. In our study population, no case of IUFD or perinatal mortality has been observed.…”

Section: Commentmentioning

confidence: 89%

Isolated single umbilical artery: evaluating the risk of adverse pregnancy outcome

Mailáth-Pokorny

Worda

Schmid

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Commentmentioning

confidence: 89%

Isolated single umbilical artery: evaluating the risk of adverse pregnancy outcome

Mailáth-Pokorny

Worda

Schmid

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Based on these findings, some authors have recommended that fetal growth should be monitored throughout pregnancy after prenatal diagnosis of a single umbilical artery. [7][8][9]11,12 As a matter of fact, throughout the study period, our management protocol for pregnancies diagnosed with ISUA included serial follow up fetal growth scans. And when fetal growth restriction was diagnosed additional fetal well being tests were performed.…”

Section: Discussionmentioning

confidence: 99%

“…6,7,11,[13][14][15]18,[20][21][22][23] On the other hand, all post-natal studies have shown that birth weight is significantly lower in ISUA pregnancies compared to control pregnancies. 5,9,10,12 This is possibly related to the fact that these are the studies with greater sample size. Moreover, since ISUA was not diagnosed …”

Section: Introductionmentioning

confidence: 99%

“…Compensatory mechanisms allow increase in blood flow through the single artery in order to meet the demands of fetal growth and development throughout pregnancy. 3 Although several studies have reported diminished fetal growth in these pregnancies, [4][5][6][7][8][9][10][11][12] others have not shown differences. [13][14][15] These contradictory findings may be attributed to diverse methodological differences in the published literature.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Should fetal growth be a matter of concern in isolated single umbilical artery?

Caldas¹,

Liao²,

Carvalho³

et al. 2014

Rev. Assoc. Med. Bras.

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Should fetal growth be a matter of concern in iSolated Single umbilical artery? rev aSSoc med braS 2014; 60(2):125-130 125original articleShould fetal growth be a matter of concern in isolated single umbilical artery? Conflict of interest: noneObjective: To examine birth weight in pregnancies with isolated single umbilical artery (ISUA). Methods: Case control study with retrospective review of 131 singleton pregnancies with isolated single umbilical artery diagnosed before birth. Control group consisted of 730 singleton pregnancies recruited prospectively, that had histological confirmation of a 3 vessels cord. Pregnancies were classified as uncomplicated or high-risk according to the presence of diseases that increase the risk of placental insufficiency during pregnancy. Mean birth weight and frequency of low birth weight (< 2.500 g), very low birth weight (< 1.500 g) and fetal growth restriction below the 5 th and 10 th centiles were compared between groups. Results: Mean birth weight difference between ISUA (n=131, 2840±701g) and control (n=730, 2.983 ± 671g) pregnancies was 143g (95% CI= 17-269; p=0.04) and birth weight below the 5 th centile was significantly more common in ISUA group [28/131 (21.4%) versus 99/730 (13.6%), p=0.02]. When only uncomplicated pregnancies were considered in both groups, no birth weight differences were observed. Amongst high-risk subgroups, birth weight below the 5 th centile remained significantly more common in ISUA compared to control pregnancies [10/35 (28.6%) versus 53/377 (14.1%), p=0.04]. Conclusion: Isolated single umbilical artery does not increase the risk of fetal growth restriction in uncomplicated singleton pregnancies.

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“…Some studies have demonstrated higher rates of preterm delivery, fetal growth restriction and perinatal mortality (Mart í nez-Payo et al 2005;Murphy-Kaulbeck et al 2010;Hua et al 2010;Burshtein et al 2011). However, Predanic et al (2005) have not found any diff erence in the incidence of smallfor-gestational age newborns between fetuses with isolated SUA and those with a 3-vessel umbilical cord.…”

Section: Introductionmentioning

confidence: 97%

Congenital heart disease and adverse perinatal outcome in fetuses with confirmed isolated single functioning umbilical artery

Júnior

Palma-Dias

Martins³

et al. 2014

J Obstet Gynaecol

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To examine the association between isolated single umbilical artery (SUA) and congenital heart disease/adverse perinatal outcome in an Australian tertiary centre. The study population was comprised of fetuses diagnosed with SUA at the mid-trimester scan between May 2003 and March 2009 during detailed ultrasound examination at The Royal Women's Hospital Melbourne, Australia. Colour Doppler was used to visualise the umbilical arteries adjacent to the fetal bladder and in a section of a free loop of cord. The diagnosis of SUA was confirmed on histopathology examination of the placenta and umbilical cord. Monochorionic twins, fetuses with chromosomal abnormalities or concurrent extracardiac anomalies were excluded from the study. A total of 261 fetuses with SUA were identified in the study period and 146 (59%) cases were isolated; no chromosomal or extracardiac abnormalities were present. Complete data were available in 104/146 pregnancies (71.2%). The mean gestational age at diagnosis was 21 weeks. A cardiac anomaly was detected in 19 of these fetuses (13.0%): six hypoplastic left heart syndromes; three coarctations of the aorta; two tetralogies of Fallot; two hypoplastic right heart syndromes; two pulmonary atresia/stenosis; one absent ductus venosus with cardiomegaly; one left isomerism; one right isomerism and one transposition of the great arteries. Fetal growth restriction was present in 9.8% (10) and preterm delivery before 34 weeks occurred in nine cases (8.7%). Our study has shown that isolated SUA is associated with cardiac anomalies, but is not associated with increased frequency of FGR and preterm delivery before 34 weeks.

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Is single umbilical artery an independent risk factor for perinatal mortality?

Abstract: Isolated SUA in our population was noted as an independent risk factor for perinatal mortality.

Cited by 48 publications

References 12 publications

Isolated single umbilical artery: evaluating the risk of adverse pregnancy outcome

Isolated single umbilical artery: evaluating the risk of adverse pregnancy outcome

Should fetal growth be a matter of concern in isolated single umbilical artery?

Congenital heart disease and adverse perinatal outcome in fetuses with confirmed isolated single functioning umbilical artery

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