Is Synovial Sarcoma a Carcinosarcoma of Connective Tissue?

Fn, Ghadially

doi:10.3109/01913128709048320

Cited by 52 publications

(17 citation statements)

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“…Despite its name, SS arises from tissues other than normal synovial lining. Ultrastructural studies of epithelium-like cells in biphasic synovial sarcomas revealed characteristics of a true glandular epithelium, which were not observed in either superficial or deeper cells of synovium [21]. Further, immunohistochemical studies have demonstrated keratins and epithelial membrane antigen-positive epithelium-like cells in biphasic synovial sarcomas and unlike those found in the lining cells of synovium [43].…”

Section: Introductionmentioning

confidence: 96%

Neuronal Differentiation of Synovial Sarcoma and Its Therapeutic Application

Ishibe

Nakayama

Aoyama

et al. 2008

Clin Orthop Relat Res

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Synovial sarcoma is a rare sarcoma of unknown histologic origin. We previously reported the gene expression profile of synovial sarcoma was closely related to that of malignant peripheral nerve sheath tumors, and the fibroblast growth factor (FGF) signal was one of the main growth signals in synovial sarcoma. Here we further demonstrate the neural origin of synovial sarcoma using primary tumors and cell lines. The expression of neural tissuerelated genes was confirmed in synovial sarcoma tumor tissues, but the expression of some genes was absent in synovial sarcoma cell lines. Treatment of synovial sarcoma cell lines with BMP4 or FGF2 enhanced or restored the expression of neural tissue-related genes and induced a neuron-like morphology with positive Tuj-1 expression. Treatment with all-trans-retinoic acid also induced the expression of neural tissue-related genes in association with growth inhibition, which was not observed in other cell lines except a malignant peripheral nerve sheath tumor cell line. A growth-inhibitory effect of all-trans-retinoic acid was also observed for xenografted tumors in athymic mice. The simultaneous treatment with FGF signal inhibitors enhanced the growth-inhibitory effect of all-trans-retinoic acid, suggesting the combination of growth signaling inhibition and differentiation induction could be a potential molecular target for treating synovial sarcoma.

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Section: Introductionmentioning

confidence: 96%

Neuronal Differentiation of Synovial Sarcoma and Its Therapeutic Application

Ishibe

Nakayama

Aoyama

et al. 2008

Clin Orthop Relat Res

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“…In such cases attenuated or poorly developed desmosomes may occur in which the details of the intercellular gap are lacking, but slender dense plaques may be observed with intermediate filaments converging on the plaques (1 1). Desmosome-like structures are occasionally found in cells of mesenchymal origin (e.g., fibroblasts, Ewing's sarcoma, and neuroblastoma) (10,11,24,25); however, they contrast with true desmosomes (including attenuated desmosomes). In the present study, we found attenuated desmosomes in the Tg.AC spindle cell tumors examined with a few intermediate filaments converging on the attachment plaques (Fig.…”

Section: Rt-pcr Analysis Of Tumor Tissue For Expression Of the Ras Trmentioning

confidence: 99%

Morphological Characterization of Spindle Cell Tumors Induced in Transgenic Tg.AC Mouse Skin

et al. 1998

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ABSTRAC~Transgenic Tg.AC mice carry a v-Ha-rus coding region flanked by a <-globin promoter and an SV40 polyadenylation signal sequence. These mice respond to carcinogens by developing epidermal papillomas. In some cascs, malignancies develop at the sites of these papillomas. Various patterns of squamous cell differentiation were observed in these malignancies. One malignancy that developed at the site of the papillomas was composed of bundles of spindle cells. This lesion is difficult to distinguish from fibrosarcomas by light microscopy. We characterized 16 of these malignancies (tentatively classified as spindle cell tumors) to determine if they were of epithelial or mesenchymal origin. Papillomas were induced in Tg.AC mice by full thickness wounding, 12-0-tetradecanoyl-13-phorbol acetate treatment. or ultraviolet radiation. With time, some papillomas became broad-based, downwardly invading lesions. These lesions were examined by light microscopy with.immunohistochemica1 analysis for cytokeratins and by electron microscopy. Immunohistochemical examination with a polyclonal anti-cytokeratin antibody demonstrated various degrees of keratin staining in all tumors examined. Attenuated desmosomes were also observed in these lesions by electron microscopy. These results indicate an epithelial origin for these malignancies; therefore, they should be classified as spindle cell carcinomas.

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“…In these tumors, the cells lining the glandlike spaces look like epithelial cells, and they have typical features of epithelial cells-they are positive for cytokeratin, have desmosomes, and lie on a basement membrane. 3,6,8 These are not features of the synovial intima.…”

Section: Letters To the Editor Editormentioning

confidence: 99%

Letter to the Editor

Fairley¹

2002

Vet Pathol

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Is Synovial Sarcoma a Carcinosarcoma of Connective Tissue?

Cited by 52 publications

References 0 publications

Neuronal Differentiation of Synovial Sarcoma and Its Therapeutic Application

Neuronal Differentiation of Synovial Sarcoma and Its Therapeutic Application

Morphological Characterization of Spindle Cell Tumors Induced in Transgenic Tg.AC Mouse Skin

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