“…Using frequent saline flushes substitution for heparin anticoagulation to maintain filter life was confirmed as an effective mode of maintenance of extracorporeal circuit in CRRT. 16,17 So, in our experiment, we used frequent saline flushes substitution for heparin anticoagulation. In our experiment, 11 patients in the heparin-free CVVH in the course of treatment, no bleeding, severe coagulation (need to replace the dialyzer or pipeline), and so on were found.…”