Is TGF-β important for the evolution of subcutaneuos chronic mycoses?

Quaresma, Juarez Antônio Simões; Oliveira, Euzébio de; Brito, Arival Cardoso de

doi:10.1016/j.mehy.2007.10.010

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…25,26 Once on the dermis, a slow replication process seems to initiate after it has been phagocytised by phagocytic-mononuclear linage cells, 27,28 lending an explanation to the slow incubation period and slow development of lesions. Moreover, it has been described that the phagocytic activity could be affected through TGFb -a cytokine that strongly suppresses macrophagic activity and has the capacity of inhibiting nitric oxide and gamma interferon expression, consequently impacting cell mediated immunity -leading to an antigen-specific cell mediated immune deficiency, [29][30][31] evident in other similar clinically entities such as diffuse cutaneous leishmaniasis and lepromatous leprosy. 32 It has been hypothesised that another cell population, LangerhanÕs cells may play a role modulating the local immune system to evade antigen presentation by those cells.…”

Section: Aetiology and Pathologymentioning

confidence: 99%

Lobomycosis: an emerging disease in humans and delphinidae

Paniz-Mondolfi

Talhari

Hoffmann

et al. 2012

Mycoses

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Summary Lobomycosis, a disease caused by the uncultivable dimorphic onygenale fungi Lacazia loboi, remains to date as an enigmatic illness, both due to the impossibility of its aetiological agent to be cultured and grown in vitro, as well as because of its unresponsiveness to specific antifungal treatments. It was first described in the 1930s by Brazilian dermatologist Jorge Lobo and is known to cause cutaneous and subcutaneous localised and widespread infections in humans and dolphins. Soil and vegetation are believed to be the chief habitat of the fungus, however, increasing reports in marine mammals has shifted the attention to the aquatic environment. Infection in humans has also been associated with proximity to water, raising the hypothesis that L. loboi may be a hydrophilic microorganism that penetrates the skin by trauma. Although its occurrence was once thought to be restricted to New World tropical countries, its recent description in African patients has wrecked this belief. Antifungals noted to be effective in the empirical management of other cutaneous/subcutaneous mycoses have proven unsuccessful and unfortunately, no satisfactory therapeutic approach for this cutaneous infection currently exists.

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Section: Aetiology and Pathologymentioning

confidence: 99%

Lobomycosis: an emerging disease in humans and delphinidae

Paniz-Mondolfi

Talhari

Hoffmann

et al. 2012

Mycoses

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“…If lobomycosis can be confirmed in its early stages, then surgical excision of local lesions may be curative for the patient [Elsayed et al 2004]. Medical management remains difficult and lengthy at this time with limited success in treatment [Quaresma et al 2008].…”

Section: Resultsmentioning

confidence: 99%

“…An important feature of lobomycosis is the high expression of the cytokine transforming growth factor beta (TGF-b), which acts to suppress macrophage activity, as measured by a decrease in the marker CD68 [Quaresma et al 2008;Xavier et al 2008]. It has also been found in high quantities in other acute and chronic disease processes, such as chronic hepatitis, leprosy, and yellow fever [Xavier et al 2008].…”

Section: Discussionmentioning

confidence: 99%

Jorge Lobo’s disease: a case of keloidal blastomycosis (lobomycosis) in a nonendemic area

Arju

Kothadia²,

Kaminski

et al. 2014

Therapeutic Advances in Infection

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“…It contributes to the differentiation of the Treg response, inhibits macrophagic responses, and acts as an immunosuppressive cytokine (301,(375)(376)(377). Moreover, TGF-␤ seems to play a major role in the evolution of several infectious diseases of the skin, including leprosy, lacaziosis, cutaneous leishmaniasis, and chromoblastomycosis (96,359,375,376,(378)(379)(380). Depending on its relationship with other cytokines and humoral factors of the host's response, TGF-␤ has numerous roles in the tissue microenvironment.…”

Section: Overview Of the Relationship Between Skin Immune System And mentioning

confidence: 99%

Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

Quaresma

2019

Clin Microbiol Rev

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SUMMARY The skin is an organ harboring several types of immune cells that participate in innate and adaptive immune responses. The immune system of the skin comprises both skin cells and professional immune cells that together constitute what is designated skin-associated lymphoid tissue (SALT). In this review, I extensively discuss the organization of SALT and the mechanisms involved in its responses to infectious diseases of the skin and mucosa. The nature of these SALT responses, and the cellular mediators involved, often determines the clinical course of such infections. I list and describe the components of innate immunity, such as the roles of the keratinocyte barrier and of inflammatory and natural killer cells. I also examine the mechanisms involved in adaptive immune responses, with emphasis on new cytokine profiles, and the role of cell death phenomena in host-pathogen interactions and control of the immune responses to infectious agents. Finally, I highlight the importance of studying SALT in order to better understand host-pathogen relationships involving the skin and detail future directions in the immunological investigation of this organ, especially in light of recent findings regarding the skin immune system.

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Is TGF-β important for the evolution of subcutaneuos chronic mycoses?

Cited by 9 publications

References 19 publications

Lobomycosis: an emerging disease in humans and delphinidae

Lobomycosis: an emerging disease in humans and delphinidae

Jorge Lobo’s disease: a case of keloidal blastomycosis (lobomycosis) in a nonendemic area

Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

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