Is the Mean Platelet Volume Predictive of Hip Fractures in the Elderly?

Cüre, Erkan; Balık, Mehmet Sabri; Güvercin, Yılmaz; Erkut, Adem; Yüce, Süleyman; Keskin, Davut

doi:10.3343/alm.2013.33.5.367

Cited by 19 publications

(12 citation statements)

References 12 publications

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“…[10,11] These cytokines enhance oxidative stress, which contributes to platelet activation. Platelet activation leads to the release of immature and activated thrombocytes from bone marrow to peripheral blood, thus increasing MPV levels.…”

Section: Discussionmentioning

confidence: 99%

The association between serum YKL-40 levels, mean platelet volume, and c-reactive protein in patients with cellulitis

Ertürk

Cüre

et al. 2015

Indian Journal of Medical Microbiology

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Section: Discussionmentioning

confidence: 99%

The association between serum YKL-40 levels, mean platelet volume, and c-reactive protein in patients with cellulitis

Ertürk

Cüre

et al. 2015

Indian Journal of Medical Microbiology

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“…They also noted that the increase in MPV was accompanied by increased proinflammatory cytokine levels. Cure et al 42 demonstrated that a high MPV was associated with fractures, even in old age. Increased MPV may be related to osteoporosis and an impaired blood supply; consequently, the risk of fracture may be increased.…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between fracture healing and mean platelet volume?

Serbest¹,

Tiftikçi²,

Tosun³

et al. 2016

TCRM

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ObjectivesPlatelet volume has been defined to be a marker that shows thrombocyte activation and function and it is measured as mean platelet volume (MPV). MPV shows the mean volume of circulating thrombocytes and it is one of the routine parameters in complete blood count. Increased thrombocyte volume is associated with thrombocyte activation.Patients and methodsThis study included 76 patients who were operated on due to fractures of long tubular bones. Patients who had union without any additional interventions were defined as group I, and patients who needed additional interventions due to nonunion or inadequate union were defined as group II. The control group included healthy volunteers who did not have a fracture. Hematologic test values of the patients that were obtained at admission to emergency ward were recorded.ResultsThe groups were not statistically different in terms of age, sex, and the affected extremity. There were significant differences between group I and group II in terms of mean erythrocyte sedimentation rate, C-reactive protein, and MPV values (P<0.001), but there were no significant differences between group I and the control group. There was also no statistically significant difference among groups in terms of hematologic and biochemical variables.ConclusionIn our study, fractures in patients who had lower MPV values than controls during the inflammation process healed without any problem, but fractures in patients with high MPV values more frequently needed additional surgical interventions.

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“…Vitamin D suppresses activation of TNF-alpha-converting enzyme (TACE) in renal cells by inhibiting release of mediators of systemic inflammation, namely tumor necrosis factor alpha (TNF-alpha), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion molecule 1 (VCAM-1), into the circulation [28], which explains its anti-inflammatory effects. Also, TNF-alpha and IL-6 decreased by vitamin D therapy [29], are related to oxidative stress and stimulate megakaryopoiesis [30]. Vitamin D has also been shown to have anticoagulant effects on monocytic leukemia cells and monocytes, analogous to retinoic acids [4].…”

Section: Discussionmentioning

confidence: 99%