2017
DOI: 10.1007/s10585-017-9854-x
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Is the non-sentinel lymph node compartment the next site for melanoma progression from the sentinel lymph node compartment in the regional nodal basin?

Abstract: Melanoma patients with additional positive lymph nodes in the completion lymph node dissection (CLND) following a positive sentinel lymph node (SLN) biopsy would have a poorer prognosis than patients with no additional positive lymph nodes. We hypothesize that the progression of disease from the SLN to the non-SLN compartment is orderly and is associated with the worsening of the disease status. Thus, the SLN and non-SLN compartments are biologically different in that cancer cells, in general, arrive in the SL… Show more

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Cited by 14 publications
(6 citation statements)
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“…The results of our study are consistent with MSLT‐II, since patients with positive CLND had significantly worse OS and MSS compared with patients with negative CLND. Clearly, the presence of nonsentinel metastases is a powerful predictor of outcomes …”
Section: Discussionmentioning
confidence: 99%
“…The results of our study are consistent with MSLT‐II, since patients with positive CLND had significantly worse OS and MSS compared with patients with negative CLND. Clearly, the presence of nonsentinel metastases is a powerful predictor of outcomes …”
Section: Discussionmentioning
confidence: 99%
“…However, omitting CLND could result in underestimation of patients at high risk progression and so in an impaired selection for adjuvant therapy. In fact, there is an approximately 20% of melanoma patients harboring metastatic disease in non-sentinel nodes (5)(6)8,(13)(14)(15)(16) . In order to predict the presence of disease in NSN for follow up personalization in clinical practice and for patient risk stratification, Italian Melanoma Intergroup (IMI) built a nomogram for prediction NSN status in melanoma patients with positive SNB (4) .…”
Section: Introductionmentioning
confidence: 99%
“…Clinical practice has changed dramatically since CLND is expected no longer to be standard procedure after a positive SNB. However, there is a 20% chance of having non-SN (NSN) positivity in CLND after a positive SNB [7]. In cutaneous melanoma patients, the presence of disease in NSNs has been found to be a strong independent adverse prognostic factor for survival [8].…”
Section: Introductionmentioning
confidence: 99%