Is the questionnaire for the assessment of gastroesophageal reflux useful for diabetic patients?

Kinekawa, Fumihiko; Kubo, Fumiyoshi; Matsuda, Kazuya; Kobayashi, Mitsuyoshi; Furuta, Yasuo; Yamanouchi, Hideo; Inoue, Hirokazu; Kurata, Hirohide; Uchida, Yuzo; Kuriyama, Shigeki

doi:10.1080/00365520500217043

Cited by 16 publications

(10 citation statements)

References 13 publications

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“…These findings were also supported by Kinekawa et al [21], who hardly found any reflux symptoms in 53 patients investigated by a structured questionnaire. Autonomic NP with damage of efferent and afferent nerve fibers has been made responsible for this phenomenon and it was concluded that GERD questionnaires were not useful for diabetic patients [21]. However, one may criticize that both authors [11,21] used questionnaires which have not been validated and lack adequate reliability and responsiveness [22][23][24].…”

Section: Gerd Related Symptomssupporting

confidence: 75%

“…Interestingly, patients with end-stage diseases suffering from DM type II for more than 16 years show a decrease of reflux symptoms [11]. These findings were also supported by Kinekawa et al [21], who hardly found any reflux symptoms in 53 patients investigated by a structured questionnaire. Autonomic NP with damage of efferent and afferent nerve fibers has been made responsible for this phenomenon and it was concluded that GERD questionnaires were not useful for diabetic patients [21].…”

Section: Gerd Related Symptomsmentioning

confidence: 65%

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Gastroesophageal reflux disease in diabetic patients: a systematic review

et al. 2007

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Gastroösophageale Refluxkrankheit bei Diabetikern: eine systematische Ü bersichtZusammenfassung. Grundlagen: Diabetes mellitus (DM) und die Gastroö sophageale Refluxkrankheit (GERD) sind in der westlichen Welt durch eine rasch steigende Inzidenz charakterisiert, die enorme Kosten verursachen. DM betrifft etwa 10% der Bevö lkerung, wä hrend GERDSymptome und Refluxö sophagitis bei rund 40% bzw. 20% beschrieben wurden.Methodik: Dieser Ü bersichtsartikel fasst den derzeitigen Wissensstand ü ber GERD bei Diabetikern zusammen und legt ein besonderes Augenmerk auf Symptome, diagnostische Ergebnisse, pathophysiologische Zusammenhä nge und Therapieoptionen. Der Evidenzgrad ist gering, da es sich bei den meisten Arbeiten um Fall-Kontrollstudien mit limitierter Patientenzahl (Evidenz-Level IIIb) und Fallserien (Evidenz-Level IV) handelt.Ergebnisse: Refluxsymptome werden bei rund 50% der Diabetiker beschrieben, wobei sie bei Patienten mit oraler antidiabetischer Therapie am stä rksten ausgeprä gt sind. Lang bestehende Krankheitsdauer, schlechte Blutzuckereinstellung mit erhö hten HbA 1c -Werten und Ü bergewicht verstä rken diese Beschwerden. Die erosive Ö sophagitis betrifft mehr als 40% der Diabetiker mit einer hö heren Prä valenz bei Vorliegen einer autonomen Neuropathie. PH-metrische Untersuchungen waren bei bis zu 90% symptomatischer Refluxpatienten pathologisch, wä hrend bislang widersprü chliche manometrische Ergebnisse beschrieben wurden. Vermehrte Magensä ure-, verminderte Bikarbonatund Speichelsekretion, gesteigertes Auftreten von transienten Sphinkterrelaxationen und ein verminderter Tonus des unteren Ö sophagussphinkters sind an der Entstehung der Refluxkrankheit ebenso beteiligt wie verminderte Ö sophagus-und Magenmotilitä t. Ü berdies ist die Heilung von Schleimhautverletzungen bei Diabetikern verzö gert. Daten zur Therapie der GERD bei Diabetikern mittels Protonenpumpenihibitoren sind ebenso wenig verfü gbar wie Studien ü ber die interventionelle oder chirurgische Behandlung dieser Patienten.Schlussfolgerungen: Es gibt einige Hinweise dafü r, dass Diabetes, unabhä ngig von Adipositas, ein Risikofaktor fü r die Entstehung der GERD ist. Spezifische pathophysiologische Mechanismen sind fü r die Genese der GERD bei Diabetikern von Bedeutung, was die Notwendigkeit weiterer Studien unterstreicht.Schlü sselwö rter: Gastroö sophageale Refluxkrankheit (GERD), Diabetes mellitus, Hyperglykä mie, Neuropathie, Ü bergewicht.Summary. Background: Diabetes mellitus (DM) and gastroesophageal reflux disease (GERD) are characterized by a rapidly increasing incidence within the Western World causing incredible costs. DM affects about 10% of the population, whereas GERD symptoms and GERD related esophagitis have been reported in 40% and 20%, respectively.Methods: This systematic review deals with the current knowledge on GERD in diabetic patients with special reference to symptoms, diagnostic outcomes, pathophysiologic characteristics and treatment strategies. The evidence level is low, as most of the contributions are individual ca...

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Section: Gerd Related Symptomssupporting

confidence: 75%

Section: Gerd Related Symptomsmentioning

confidence: 65%

Gastroesophageal reflux disease in diabetic patients: a systematic review

et al. 2007

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“…There is another important issue concerning GERD in diabetic patients. Kinekawa et al [124] examined 53 diabetic patients by QUEST immediately before 24-h pH monitoring. They found that diabetic patients had fewer symptoms and extremely low scores, and there was no difference in scores between patients with and without GER.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Epidemiology and clinical characteristics of GERD in the Japanese population

2009

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We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in this country. Although the definition of GERD depends on the individual study, the prevalence of GERD has been increasing since the end of the 1990s. The reasons for the increase in the prevalence of GERD may be due to increases in gastric acid secretion, a decrease in the Helicobacter pylori infection rate, more attention being paid to GERD, and advances in the concept of GERD. More than half of GERD patients had non-erosive reflux disease, and the majority (87%) of erosive esophagitis was mild type, such as Los Angeles classification grade A and grade B. There were several identified risk factors, such as older age, obesity, and hiatal hernia. In particular, mild gastric atrophy and absence of H. pylori infection influence the characteristics of GERD in the Japanese population. We also discuss GERD in the elderly; asymptomatic GERD; the natural history of GERD; and associations between GERD and peptic ulcer disease and H. pylori eradication. We examined the prevalence of GERD in patients with specific diseases, and found a higher prevalence of GERD, compared with that in the general population, in patients with diabetes mellitus, those with obstructive sleep apnea syndrome, and those with bronchial asthma. We provide a comprehensive review of GERD in the Japanese population and raise several clinical issues.

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“…37,38 Consequently, an exact evaluation of esophageal dysfunction on the basis of symptoms may be diffi cult in patients with diabetes. 4,39 Typical refl ux symptoms may be vague in diabetic patients. Another questionnaire, for example, the GSRS 40 or FSSG, 41 which can evaluate abdominal discomfort or dysmotility symptoms, may be more suitable in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%