Is the rs1801282 (G/C) Polymorphism of PPAR - Gamma Gene Associated with T2DM in Iraqi People?

Abstract

BACKGROUND:Pro12Ala (rs1801282) is a common polymorphism of the human PPAR-γ gene. Studies have demonstrated conflicting results about its association with T2DM worldwide. There are no reports about such possible association among Iraqi people.OBJECTIVES:This study aims at finding out whether having the mutant allele (Ala12) might be associated with T2DM among Iraqi people.METHODS:One hundred and ninety-two Arabic Iraqi adult subjects (97 with T2DM and 95 controls) were genotyped using PCR- RFLP. Clinical, anthropometrical and biochemical variables were compared regarding the Pro12Ala genotypes.RESULTS:About 5.67% of people with diabetes were carriers of the (Ala12) allele versus 9.47% of controls. Allelic and genotypic frequencies were not statistically different among diabetics and controls [(χ2= 1.99, p= 0.16) and (χ2= 2.17, p= 0.14)]. Age, BMI and smoking- but not Pro12Ala - were independent risk factors for T2DM in our subjects. Pro12Ala was not associated with T2DM (Odd’s ratio 0.55, 95% CI 0.23- 1.32, p= 0.14).CONCLUSIONS:Our study revealed a relatively high frequency of the Ala12 allele among Arabic Iraqis. These frequencies did not significantly differ between diabetics and controls indicating the absence of association of Pro12Ala with T2DM among Iraqis.

The Effect Sizes of PPARγ rs1801282, FTO rs9939609, and MC4R rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study

“…The frequencies of the PPARγ Pro12Ala genotypes were 91.9% for C/C, 8.1% for C/G and 0% for G/G in the Emirati population [39], compared to 87.3%, 11.6%, and 1.1%, respectively, in the diabetic group data in the present study. Similar to our findings here, recent studies in Iraqi and Egyptian populations reported no significant association in their cohorts with T2DM [40,41]. In addition, the Egyptian study showed no significant differences in PPARγ Pro12Ala genotypes and T2DM parameters (BMI, HbA1c, FBS, triglyceride, and cholesterol) [40].…”

The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review

“…Некоторые исследования, проведенные на различных популяциях, ассоциации генотипа GG полиморфизма rs1801282 гена PPARG с риском развития СД 2 не показали [32][33][34][35][36][37][38][39][40]. Однако при оценке влияния сочетания ряда полиморфизмов генов оказалось, что, например, генотип СС гена rs1801282 PPARG повышает риск СД 2 при наличии генотипа АТ полиморфизма rs9939609 гена FTO [41].…”

PPARG genindeki Pro12Ala polimorfizmi, Türk populasyonunda insülin direnci ve tip 2 diyabet ile ilişkili değildir: Bir vaka-kontrol çalışması

“…2007 ve 2008 yıllarında gerçekleştirilen GWA çalışmalarında da T2D ile ilişkisi teyit edilen birkaç genden biri de yine PPARG geni (P12A varyantı)'dir [20][21][22]. PPARG'nın Tip 2 diyabet ile ilişkisine yönelik daha önceleri de çalışmalar yapılmış ancak hastalık bakımından koruyucu [14,[23][24][25][26], risk faktörü [27][28][29][30] ya da herhangi bir ilişkisinin olmadığı [31][32][33][34][35] gibi farklı populasyonlarda farklı sonuçlar rapor edilmiştir. Bizim çalışmamızda, Tip 2 diyabet ile PPARG genindeki Pro12Ala polimorfizmi arasında herhangi bir ilişki tespit edilmemiştir.…”